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Preparation method of a medicinal composition for invigorating the spleen, warming the middle, dispelling cold and relieving diarrhea

A technology of invigorating the spleen and warming the middle and the composition, which is applied in the field of preparation of pharmaceutical compositions, can solve the problems of high extraction temperature, long extraction time, cumbersome process, etc., and achieve the effects of improved purity, excellent antidiarrheal effect, and reduced irritation

Active Publication Date: 2017-10-03
YABAO PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The combination of cloves, cinnamon and Piper longum can prevent and treat diarrhea in infants and young children. It is the exclusive product of Yabao Pharmaceutical Group. The traditional process is to steam distill part of the medicinal materials to extract the volatile oil, decoct the concentrated clear ointment, and crush the remaining medicinal materials into fine powder. The method of mixing clear paste into fine powder and drying, and finally using volatile oil, clear paste, and fine powder as medicine; but the extraction of volatile oil by steam distillation has the following disadvantages: the extraction temperature is high, the process of oil extraction needs to keep the aqueous solution in a boiling state, and heat-sensitive components are easy to extract. Degradation, long extraction time, high energy consumption, and requires oil-water separation, cumbersome process
[0006] Our company continuously upgrades the technology on the basis of the traditional technology, and inspects the feasibility of using supercritical extraction technology to extract the active ingredients. Safety risks posed by active ingredients
The prior art discloses a method for extracting a single-flavored medicinal material using supercritical and molecular distillation combined technology, but there is no method for simultaneously extracting a multi-flavored medicinal material composition

Method used

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  • Preparation method of a medicinal composition for invigorating the spleen, warming the middle, dispelling cold and relieving diarrhea
  • Preparation method of a medicinal composition for invigorating the spleen, warming the middle, dispelling cold and relieving diarrhea
  • Preparation method of a medicinal composition for invigorating the spleen, warming the middle, dispelling cold and relieving diarrhea

Examples

Experimental program
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Effect test

Embodiment 1

[0140] Example 1: Preparation of the pharmaceutical composition of the present invention

[0141] Take 500g of cloves, 400g of cinnamon and 5g of Piper longum longum, crush (size 40 mesh), supercritical extraction, extraction temperature is 45℃, extraction pressure is 30MPa, separation temperature is 35℃, separation pressure is 5MPa, extraction time is 4 hours , CO 2 The flow rate is 20kg / hour, the volatile oil is collected, and the medicine residue is ready for use; the medicine residue is extracted with 95% ethanol of 20% of the medicinal material as an entrainer for 2 hours, the ethanol solution is collected, and concentrated under reduced pressure to a relative density of 1.25-1.30 (60 ℃) thick paste, dried under reduced pressure to obtain dry extract; the volatile oil obtained by supercritical extraction, using molecular distillation equipment at a distillation temperature of 70 ℃, distillation pressure of 60 Pa, feed rate of 1ml / min, scraping speed Under the condition of 30...

Embodiment 2

[0142] Example 2: Preparation of the pharmaceutical composition of the present invention

[0143] Take 500g of cloves, 250g of cinnamon and 5g of tuber longum, crush (size 40 mesh), supercritical extraction, extraction temperature is 50℃, extraction pressure is 25MPa, separation temperature is 35℃, separation pressure is 7MPa, extraction time is 6 hours , CO 2 The flow rate is 30kg / hour, the volatile oil is collected, and the medicine residue is ready to be used; the medicine residue is extracted with 95% ethanol with 10% of the medicinal material as an entrainer for 4 hours, the ethanol solution is collected, and concentrated under reduced pressure to a relative density of 1.25-1.30 (60 ℃) thick paste, dried under reduced pressure to obtain dry extract; the volatile oil obtained by supercritical extraction, using molecular distillation equipment at the distillation temperature of 60 ℃, distillation pressure of 60 Pa, feed rate of 2ml / min, scraping speed Under the condition of 35...

Embodiment 3

[0144] Example 3: Preparation of the pharmaceutical composition of the present invention

[0145] Take 500g of cloves, 750g of cinnamon and 5g of Piper longum L., crush (particle size is 30 mesh), supercritical extraction, extraction temperature is 40℃, extraction pressure is 35MPa, separation temperature is 55℃, separation pressure is 3MPa, extraction time is 2 hours , CO 2 The flow rate is 30kg / hour, the volatile oil is collected, and the medicine residue is ready for use; the medicine residue is extracted with 90% ethanol with 30% of the medicinal material as the entrainer for 1 hour, the ethanol solution is collected, and concentrated under reduced pressure to a relative density of 1.25-1.30 (60 ℃) thick paste, dried under reduced pressure to obtain dry extract; the volatile oil obtained by supercritical extraction, using molecular distillation equipment at a distillation temperature of 80 ℃, distillation pressure of 180 Pa, feed rate of 0.5ml / min, scraping film Under the con...

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Abstract

The invention discloses a preparation method of a medicinal composition for invigorating the spleen, warming the middle, dispelling cold and relieving diarrhea, which comprises taking three medicinal materials of clove, cinnamon and longan longan, pulverizing them, performing supercritical extraction, and continuing to extract the entraining agent, and making the three medicinal materials The active ingredient is completely extracted; the volatile oil obtained by supercritical extraction is further subjected to molecular distillation to improve the purity of the active ingredient and reduce impurities; the dry extract obtained by the extraction of the entrainer is crushed and mixed evenly with the above-mentioned volatile oil to obtain the product. The appearance and smell of the composition extracted by the preparation method of the present invention are significantly improved, including light and transparent oil color, natural and fragrant smell, and fluidity close to water, which is beneficial to further improving the appearance of the composition and reducing the irritation of medication. Simultaneously, it is confirmed by drug efficacy experiments that under the same dosage condition, the antidiarrheal effect of the pharmaceutical composition group prepared by the method of the present invention is the best.

Description

Invention field [0001] The invention relates to a preparation method of a pharmaceutical composition, in particular to a preparation method of a pharmaceutical composition for strengthening the spleen, warming the middle, dispelling cold and relieving diarrhea. Background technique [0002] Clove belongs to the warming medicine in traditional Chinese medicine. It has the effects of warming the middle and reducing the adverse effects, invigorating the kidney and promoting yang. It can treat the deficiency and cold of the spleen and stomach, hiccups, vomiting and diarrhea, cold pain in the heart and stomach, and impotence of the kidney. Clove volatile oil is the main extract of Clove, its main component eugenol has many pharmacological activities such as antibacterial, anesthetic, antipyretic, anti-oxidant, anti-tumor and so on. [0003] Cinnamon has the effects of inducing fire and returning to the source, warming the kidneys and yang, warming the middle and nourishing yang, dispell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61P1/14A61P1/12
Inventor 辛艳周海燕任武贤
Owner YABAO PHARMA GRP CO LTD