Chitosan dressing and production process thereof

A production process, chitosan technology, applied in the field of medical supplies, can solve the problems of complex performance control of chitosan, unfavorable solubility, poor appearance, poor moisture retention, etc.

Active Publication Date: 2015-04-22
DONGGUAN HONGYUAN MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of chitosan material selection, too good solubility is unfavorable for forming, and too poor solubility is unfavorable for water content. It is more suitable for dissolving during production and swelling after forming. If the molecular weight is too large, there will be no antibacterial properties. If the molecular weight is too small, the color will be too dark. , poor appearance and moisture retention, unsatisfactory antibacterial spectrum, and derivative groups also have an impact on antibacterial properties. Carboxymethyl is better, hydroxyethyl and hydroxypropyl are poor, and many other factors make the performance of chitosan control more complex

Method used

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  • Chitosan dressing and production process thereof
  • Chitosan dressing and production process thereof
  • Chitosan dressing and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Reference figure 1 , figure 2 and image 3 :

[0038] Take 350g of carboxymethyl chitosan with a molecular weight of 30,000, a deacetylation degree of 90%, a substitution degree of 0.75, a pH of the insoluble region of 4~7.5, and a pH of 7.5~9 of the swelling region, add 1100g of glycerin, and 8550g of purified water, and stir well Swell to get a coating with a viscosity of 7000mpa.s, add figure 1 In the trough of the coating machine with the structure, start the traction roller to drag the anti-sticking paper, adjust the gap between the knife edges to 0.8mm, and measure the coating amount of 648g per square meter, enter the oven, and the coating machine oven has 5 sections, and the temperature of each section is set in order. The next time is 50°C, 60°C, 70°C, 80°C, 70°C, reduce the weight to 85%, cover the pressure roller with non-woven fabric, wind up, and the roll material enters the oven again, the temperature of each section is as above, wind up, A...

Embodiment 2

[0040] Take 350g of carboxymethyl chitosan with a molecular weight of 96,000, a degree of deacetylation of 95%, a degree of substitution of 0.87, a pH of 4~7.5 in the insoluble region, and a pH of 7.5~9 in the -swelling region, add 1100g of glycerin, 8550g of purified water, and stir well Swell to get a coating with a viscosity of 8000mpa.s, add figure 1 In the trough of the coating machine with a structure, start the traction roller to drag the anti-sticking paper, adjust the gap between the knife edges to 0.8mm, and measure the coating amount to 740g per square meter, enter the oven, and the coating machine oven has 5 sections, and the temperature of each section is set in order. The second time is 50°C, 60°C, 70°C, 80°C, 70°C, the weight is reduced to 83%, the pressure roller is covered with non-woven fabric, and the roll is wound. The roll material enters the oven again. The temperature of each section is as above, and the roll is rolled. After two hours, the coil material...

Embodiment 3

[0042] Take 400g of carboxymethyl chitosan with a molecular weight of 16,000, a degree of deacetylation of 83%, a degree of substitution of 0.7, a pH of 4 to 7.5 in the insoluble region, and a pH of 7.5 to 9 in the swelling region, add 1200g of glycerin, and 8400g of purified water, and stir well Swell to get a coating with a viscosity of 6000mpa.s, add figure 1 In the trough of the coating machine with the structure, start the traction roller to drag the anti-sticking paper, adjust the gap between the knife edges to 0.8mm, and measure the coating amount of 720g per square meter, enter the oven, and the oven of the coating machine has 5 sections, and the temperature of each section is set in order The second time is 50°C, 60°C, 70°C, 80°C, 70°C, the weight is reduced to 82%, the pressure roller is covered with non-woven fabric, and the roll is wound. The roll material enters the oven again. The temperature of each section is as above, and the roll is rolled. After two hours, t...

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Abstract

The invention provides a chitosan dressing and a production process thereof. The chitosan dressing provided by the invention comprises release paper, a compound chitosan applying core layer and an adhesive tape layer which are glued in sequence, wherein the compound chitosan applying core layer comprises a chitosan coating and a water absorption cotton layer which are same in shape and area. The production process provided by the invention comprises the following steps of (1), preparing the chitosan coating; (2), punching the chitosan coating; (3), compounding the punched chitosan coating with the water absorption cotton layer to obtain a compound chitosan applying core; (4), compounding the compound chitosan applying core with the adhesive tape layer and the release paper through a dressing machine to obtain the chitosan dressing; and (5), bagging, boxing, casing, irradiating and sterilizing the chitosan dressing so as to obtain the product. In the prior art, the chitosan layer is larger than the water absorption cotton layer so that the water absorption cotton layer is very easy to fall off, but according to the invention, the chitosan layer and the water absorption cotton layer are identical in area and can be glued to form the compound chitosan applying core layer, so use is convenient and falling is not generated.

Description

technical field [0001] The invention belongs to the field of medical supplies, and in particular relates to a chitosan dressing and a production process thereof. Background technique [0002] Dressing is an important product of modern wound care, and its development has mainly gone through two stages: [0003] Sterility - The Dry Healing Theory [0004] In 1867, Joseph Lister pioneered the concept of asepsis and used dressings for surgical incision care for the first time. The theory he advocated to keep the wound surface dry and breathable has a history of more than 100 years. The wide application of cotton gauze dressings has greatly reduced the chances of patients being infected after surgery, which is a major advance in trauma management. The dry healing theory believes that wound healing requires a dry environment, and the participation of atmospheric oxygen can promote wound healing, so a breathable dressing can make the wound obtain enough oxygen for various biochem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61F13/02
Inventor 彭连生李祥永
Owner DONGGUAN HONGYUAN MEDICINE TECH
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