Method for extracting and purifying effective parts of peanut shells

Abstract

The invention provides a method for extracting and purifying effective parts of peanut shells, and belongs to the technical field of natural medicine extraction. The purity of luteolin at the extracted effective parts of the peanut shells reaches 60%. The method specifically comprises the following steps: (1) carrying out extracting with an ethanol aqueous solution under micropressure; (2) concentrating; (3) performing recrystallization; (4) performing column chromatography. The greatest feature of the method is that the operation is simple and economical, requirements on instrument and equipment are low, the production period is short, and the method is suitable for industrial production; only ethanol and water which are used as reagents are adopted, so that the method is safe and reliable, and the obtained effective parts can be directly used for study of peanut shell efficacy or pharmacology.

Description

technical field [0001] The invention belongs to the technical field of natural medicine extraction, and in particular relates to a method for extracting and purifying effective parts of peanut shells. Background technique [0002] In recent years, a large number of literatures have pointed out that peanut shell extract has anti-oxidation, lowering blood fat, inhibiting platelet aggregation, and lowering blood pressure. However, the application of many peanut shells stays on the crude extract, without further processing and quality control indicators for quality control, and the technical content and added value are low. [0003] The flavonoids in peanut shells are the main bioactive substances, and the flavonoids with higher content in peanut shells are luteolin. Its structure is as follows: [0004] [0005] According to literature reports, luteolin has antiviral, antibacterial, antitumor, lowering blood lipid and cholesterol, and cardiovascular disease prevention effe...

AI Technical Summary

Problems solved by technology

However, according to the definition of effective parts of traditional Chinese medicine, the ingredients must be one or several types of chemical components extracted from traditional Chinese medicine, so the chemically synthesized luteolin cannot be used as the effective part of peanut shells for research

[0007] The Chinese patent with publication number CN101712669 introduces a method for extracting luteolin assisted by ultrasonic waves. Due to the limitation of ultrasonic equipment, this method can only be limited to small-scale experiments and cannot be industrialized.

[0008] The Chinese patent with the publication number CN102040579 introduces a method for extracting luteolin from peanut roots, peanut stems, peanut leaves, and peanut shells. According to the method, it needs to go through multiple large-volume solution dissolution and concentration processes, and the process is relatively complicated. high energy consumption

[0009] To sum up, the chemical synthesis method cannot be used for pharmacological research on the effective parts of peanut shells with luteolin as the quality control index. The method in the publication number CN101712669 cannot be industrialized, and the method in the publication number CN102040579 is relatively complicated. The energy consumption is high, so it is of great significance to develop a simple, economical and suitable method for the extraction and purification of effective parts of peanut shells, which can provide a stable and reliable material basis for the study of the pharmacological effects of peanut shells

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