Method for extracting and purifying effective parts of peanut shells

A technology for effective parts and peanut shells, which is applied in the field of extracting and purifying effective parts of peanut shells, can solve the problems of incapability of industrial production, inability to study luteolin in peanut shells, and complicated processes.

Inactive Publication Date: 2015-04-29
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

However, according to the definition of effective parts of traditional Chinese medicine, the ingredients must be one or several types of chemical components extracted from traditional Chinese medicine, so the chemically synthesized luteolin cannot be used as the effective part of peanut shells for research
[0007] The Chinese patent with publication number CN101712669 introduces a method for extracting luteolin assisted by ultrasonic waves. Due to the limitation of ultrasonic equipment, this method can only be limited to small-scale experiments and cannot be industrialized.
[0008] The Chinese patent with the publication number CN102040579 introduces a method for extracting luteolin from peanut roots, peanut stems, peanut leaves, and peanut shells. According to the method, it needs

Method used

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  • Method for extracting and purifying effective parts of peanut shells

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Comparison scheme
Effect test

Embodiment 1

[0016] Put 2.5kg of peanut shell powder into a multi-functional extraction tank, add 20L of 85% ethanol solution, extract at 80°C for 1 hour under slight pressure, and repeat the extraction twice. The combined solution was concentrated, and the precipitate was collected by standing, and the precipitate was dissolved with 2L of 80% ethanol solution, and the supernatant was filtered; 2L of distilled water was added to the supernatant, and the supernatant was filtered; 4L of water was continued to be added to the obtained supernatant, The precipitate was filtered. Continue to dissolve the precipitate with 100% ethanol solution, and repeat the above crystallization process once to obtain the precipitate; dissolve the final precipitate with 40% ethanol solution, remove impurities by D-101 resin adsorption, and spin dry to collect the obtained solution to obtain The effective part of peanut shell, its luteolin purity is 60%.

Embodiment 2

[0018] Put 5kg of peanut shell powder into a multi-functional extraction tank, add 40L of 90% ethanol solution, extract at 100°C for 1 hour under slight pressure, and repeat the extraction twice. Concentrate the combined solution to an extract, dissolve the extract with 5L of 60% ethanol solution, and filter to obtain a supernatant; add 2.5L of distilled water to the supernatant, filter to obtain a supernatant, and continue to add 7.5L to the obtained supernatant Distilled water, filtered to get precipitate. Continue to dissolve the precipitate with 60% ethanol solution, and repeat the crystallization process once more to obtain the precipitate; dissolve the final precipitate with 70% ethanol solution, remove impurities by D-101 resin adsorption, and spin dry the collected solution to obtain The effective part of peanut shell, its luteolin purity is 61%.

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Abstract

The invention provides a method for extracting and purifying effective parts of peanut shells, and belongs to the technical field of natural medicine extraction. The purity of luteolin at the extracted effective parts of the peanut shells reaches 60%. The method specifically comprises the following steps: (1) carrying out extracting with an ethanol aqueous solution under micropressure; (2) concentrating; (3) performing recrystallization; (4) performing column chromatography. The greatest feature of the method is that the operation is simple and economical, requirements on instrument and equipment are low, the production period is short, and the method is suitable for industrial production; only ethanol and water which are used as reagents are adopted, so that the method is safe and reliable, and the obtained effective parts can be directly used for study of peanut shell efficacy or pharmacology.

Description

technical field [0001] The invention belongs to the technical field of natural medicine extraction, and in particular relates to a method for extracting and purifying effective parts of peanut shells. Background technique [0002] In recent years, a large number of literatures have pointed out that peanut shell extract has anti-oxidation, lowering blood fat, inhibiting platelet aggregation, and lowering blood pressure. However, the application of many peanut shells stays on the crude extract, without further processing and quality control indicators for quality control, and the technical content and added value are low. [0003] The flavonoids in peanut shells are the main bioactive substances, and the flavonoids with higher content in peanut shells are luteolin. Its structure is as follows: [0004] [0005] According to literature reports, luteolin has antiviral, antibacterial, antitumor, lowering blood lipid and cholesterol, and cardiovascular disease prevention effe...

Claims

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Application Information

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IPC IPC(8): A61K36/48
Inventor 吕圭源尹巧汕陈素红宓文佳雷婧
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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