Method for preparing extract of Radix heterophylla and anti-osteoporosis drug

A technology of anti-osteoporosis and Cordyceps heterophylla, applied in the medical field, can solve the problems of no reports on the preparation method and use of the extract of Cordyceps heterophyllum, and achieve high safety effects

Inactive Publication Date: 2019-03-15
WUXI NO 3 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, there is no report on the preparation method and application of the extract of Radix heterophylla at present.

Method used

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  • Method for preparing extract of Radix heterophylla and anti-osteoporosis drug
  • Method for preparing extract of Radix heterophylla and anti-osteoporosis drug
  • Method for preparing extract of Radix heterophylla and anti-osteoporosis drug

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preparation example Construction

[0046] The method for preparing the extract of Cordyceps heterophyllum according to the embodiment of the present invention can effectively separate the extract of Cordyceps heterophyllum from natural raw materials of Cordyceps heterophyllum, and then can prepare the anti-osteogenic substance with high safety and no hepatotoxicity. Osteoporosis drugs, thus providing an effective way for the treatment of osteoporosis.

[0047] In the second aspect of the present invention, the present invention provides an anti-osteoporosis drug. According to an embodiment of the present invention, the drug includes the extract of Cordyceps heterophylla, and according to a specific embodiment of the present invention, the extract of Cordyceps heterophylla is prepared by the above-mentioned method for preparing the extract of Cordyceps heterophyllum. The inventors found that the drug has high safety and no hepatotoxicity by using the extract of Radix Polyphyllis extracted from the natural Chines...

Embodiment 1

[0052] Dried and crushed the stems of Radix heterophylla into powder, heated and refluxed the obtained raw material powder with 6-8 times the weight of 95% by volume methanol for 3 times, each time for 2-3 hours, and combined the separate products, Then the obtained product is filtered to obtain an extract, and then the extract is distilled under reduced pressure at 40-60 degrees Celsius to obtain an extract-like crude extract, and then the crude extract is diluted with water to obtain the extract containing aqueous solution, and then sequentially use petroleum ether, chloroform and ethyl acetate to extract the aqueous solution containing the extract, respectively to obtain petroleum ether extract, chloroform extract and ethyl acetate extract, and then respectively extract petroleum ether extract, chloroform extract , ethyl acetate extract, and the remaining aqueous solution after extraction are subjected to vacuum distillation at 20 to 30 degrees Celsius until the extract is c...

Embodiment 2

[0054] drying and pulverizing the stems of Radix heterophyllum into powder, heating and refluxing the obtained raw material powder with 95% ethanol of 6 to 8 times the weight and extracting 4 times, each time for 2-3 hours, combining the separate products, and then The obtained product is filtered to obtain an extract, and then the extract is distilled under reduced pressure at 40-60 degrees Celsius to obtain an extract-like crude extract, and then the crude extract is diluted with water to obtain an aqueous solution containing the extract , and then sequentially adopt petroleum ether, chloroform and ethyl acetate to extract the aqueous solution containing the extract to obtain petroleum ether extract, chloroform extract and ethyl acetate extract respectively, and then respectively extract petroleum ether extract, chloroform extract, Ethyl acetate extract and the remaining aqueous solution after extraction are distilled under reduced pressure at 20-30 degrees Celsius until the ...

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Abstract

The invention discloses a method for preparing a parthenocissus dalzielii extract and an anti-osteoporosis medicine. The method comprises the following steps: (1), crushing a parthenocissus dalzielii raw material to obtain raw material powder; (2), carrying out alcohol extraction on the raw material powder; (3), filtering the product obtained from the step (2) to obtain an extract liquid; (4), carrying out first vacuum distillation on the extract liquid to obtain a crude extract liquid; and (5), purifying the crude extract to obtain the parthenocissus dalzielii extract. According to the method, the parthenocissus dalzielii extract can be effectively separated from the natural parthenocissus dalzielii raw material, so as to prepare the anti-osteoporosis medicine which is high in safety and free of hepatotoxicity, so that an effective way is provided for treatment of osteoporosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular, the invention relates to a method for preparing an extract of Cordyceps heterophylla and anti-osteoporosis drugs. Background technique [0002] Different leaf brocade, also known as different leaf creeper, grass-leaf vine, tree snake, white flower vine, is a plant of the genus Franconia in the grape family. It is widely distributed and grows in areas with an altitude of 200 meters to 3800 meters. It often grows in cliffs, hillsides, valley forests and shrub rock crevices. There are expelling wind and dampness, dredging collaterals, hemostasis, and detoxification. Modern pharmacology has found that plants of the genus Vitis vinifera contain a variety of oligomeric stilbene compounds. Natural stilbene compounds have anti-tumor, anti-inflammatory, anti-oxidation, anti-thrombosis (inhibiting platelet aggregation), lowering blood pressure, lowering blood lipids, protecting liver, Improve l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/87A61P19/10
CPCA61K36/87A61K2236/15A61K2236/333A61K2236/39A61K2236/55
Inventor 袁凤来李霞姜东林何新龙龚芳李成万
Owner WUXI NO 3 PEOPLES HOSPITAL
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