A method for improving the hydrophilicity and flexibility of polypeptide membranes with polytrimethylene carbonate and carboxymethyl chitosan
A technology of carboxymethyl chitosan and methyl carbonate monotridecyl ether, which is applied in the field of polymer film preparation and achieves the effects of being easy to master and simple to operate
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Embodiment 1
[0017] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer
[0018] 16.1 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 3,000) were added to the dry reactor ), add 308 ml DMSO, and then add 0.048 g N , N ' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;
[0019] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer
[0020] Add 3.5 g of carboxymethyl chitosan (molecular weight: 5000) and 9 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 3000) into the dry reactor, add 163 ml dimethylmethylene Sulfone, add 0.165 g N , N ’ -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated the reaction, filte...
Embodiment 2
[0025] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer
[0026] 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight 85,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 3,500) were added to the dry reactor , add 310 ml of dimethyl sulfoxide, then add 0.031 g of N,N'-diisopropylcarbodiimide, under an inert atmosphere, stir and react at 27°C for 3 days, terminate the reaction, filter, dialyze, and dry, get the target
[0027] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer
[0028] Add 3 g of carboxymethyl chitosan (molecular weight: 5500) and 9 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 3500) into the dry reactor, add 158 ml dimethylmethylene Sulfone, then add 0.08 g N ,N ’ -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain t...
Embodiment 3
[0033] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer
[0034] 16.5 g of poly(r-methyl-L-glutamate) (molecular weight 92,000) and 7 g of carboxy-terminated polytrimethylene carbonate monotridecyl ether (molecular weight 4,000) were added to the dry reactor , add 310 ml dimethyl sulfoxide, then add 0.046 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, stir the reaction at 30°C for 4 days to terminate the reaction, Through filtration, dialysis, and drying, the target object is obtained;
[0035] 2) Synthesis of carboxymethyl chitosan-polytrimethylene carbonate graft copolymer
[0036] Add 3.1 g of carboxymethyl chitosan (molecular weight: 6000) and 9.2 g of amino-terminated polytrimethylene carbonate monotridecyl ether (molecular weight: 4000) into the dry reactor, add 158 ml dimethylmethylene Sulfone, then add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir and react at 35°C for 2 day...
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