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Tooth-cleaning composition for whitening teeth and repairing wounds

A damage repair and composition technology, which is applied in the field of tooth bleaching and tooth cleaning compositions for damage repair, can solve problems such as irritation of gastric mucosa and gastrointestinal tissue damage, and achieve the effects of reducing dosage, reducing damage and improving whitening effect

Inactive Publication Date: 2015-05-06
徐阳波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, excessive hydrogen peroxide can also irritate the oral mucosa, throat mucosa, and possible swallowing can also stimulate the gastric mucosa, causing tissue damage in the digestive tract.

Method used

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  • Tooth-cleaning composition for whitening teeth and repairing wounds
  • Tooth-cleaning composition for whitening teeth and repairing wounds
  • Tooth-cleaning composition for whitening teeth and repairing wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Add carbamide peroxide and bioglass (CaO·P2O5·K2O·SiO2) micropowder to glycerol polyethylene glycol anhydrous In the thickened carrier, mix evenly to make a toothpaste gel composition. Wherein the carbamide peroxide and bioglass account for 10% of the total weight of the colloidal composition, and the thickening carrier accounts for 90%.

Embodiment 2

[0037] Cytotoxicity test: use the agar diffusion method in YY / T 0127.9 to evaluate the cytotoxicity of dental gel compositions with different proportions, and use L929 cell line and growth medium to prepare 2.5×10 5 Aspirate 10ml of the cell suspension and add it to a petri dish and incubate for 24h. Then aspirate the culture solution, add 10ml of freshly made agar, after the agar medium solidifies, add neutral red staining solution and save for 30min, then suck off the excess staining solution. The colloid composition and the control group (the culture medium is used as the negative control group, and the filter membrane soaked in the phenol solution is used as the positive control group) are evenly coated on the filter membrane and placed in a petri dish. 5% carbon dioxide, 37 degrees Celsius constant temperature and dark culture for 24 hours. Use an inverted microscope to observe the fading area around the experimental and control materials, calculate the fading index...

Embodiment 3

[0042] Mucosa irritation: The oral mucosa irritation test specified in YY / T 0127.9 is used to evaluate the safety of the dental gel compositions with different configuration ratios.

[0043] Select golden yellow hamsters born 60-70 days old, and the males are of the same strain. The colloid composition sample was prepared according to the semi-solid material method in the standard, and the test animals were randomly divided into 6 groups, 6 animals in each group. The comparison material is freshly blended plaster of paris. After the animal was anesthetized, the test material cotton piece was sutured to the surface of the central buccal mucosa on one side of the hamster to a tight fit by suture contact method. Animals were sacrificed after 24 hours of clinical observation. According to YY / T 0127.9 Table 1 and Table 2, carry out clinical observation and histological scoring, and carry out pathological reaction grading according to Table 3, the results are as follows:

[0044]...

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PUM

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Abstract

The invention discloses a tooth-cleaning composition for whitening teeth and repairing wounds. The tooth-cleaning composition contains urea peroxide and bioactive glass. The tooth-cleaning composition is characterized in that the content of urea peroxide and bioactive glass is less than or equal to 20wt%, and the ratio of urea peroxide to bioactive glass is (0.05-1) to 1. The tooth-cleaning composition can be applied to various whitening tooth-cleaning matters for oral cavities, such as toothpaste, chewing gum, tooth coating powder, tooth strips and whitening gel and is capable of well whitening tooth surface, tooth enamel and dentine, and repairing the tooth enamel and the dentine, and therefore, the wounds are repaired.

Description

【Technical field】 [0001] The invention relates to a dentifrice composition, especially a dentifrice composition for tooth bleaching and damage restoration. 【Background technique】 [0002] Teeth are one of the vital organs of the human body. They have the functions of chewing, helping pronunciation and maintaining facial shape. However, with age changes, long-term diet, and bad living habits will cause various effects on teeth, one of the most common results is tooth discoloration, such as teeth darkening, yellowing, blackening and other coloring changes. The most common staining of teeth is due to excessive consumption of some easily staining foods such as tea, coffee, dark foods and smoking. Mainly manifested as foreign pigments or pigment deposits produced by bacteria in the mouth. If you take certain drugs when the teeth are developing, excessive intake of fluoride, or the use of tooth restoration materials will cause staining, such as tetracycline teeth, dental fluoros...

Claims

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Application Information

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IPC IPC(8): A61K8/42A61K8/25A61K8/86A61Q11/00A61P1/02A23G4/12
Inventor 徐阳波
Owner 徐阳波
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