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Applications of stilbene glucoside in preparation of medicament for improving intestinal mucosal barrier function

A technology of stilbene glycosides and intestinal mucosa, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., and can solve the problems that stilbene glycosides have not been reported in the literature.

Inactive Publication Date: 2015-05-06
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is no literature report on whether stilbene glycosides can improve intestinal mucosal barrier function

Method used

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  • Applications of stilbene glucoside in preparation of medicament for improving intestinal mucosal barrier function
  • Applications of stilbene glucoside in preparation of medicament for improving intestinal mucosal barrier function
  • Applications of stilbene glucoside in preparation of medicament for improving intestinal mucosal barrier function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Powder for Injection

[0052] Weigh 100 g of stilbene glycoside, 0.5 g of sodium metabisulfite, 9 g of sodium chloride, 40 g of mannitol, and 20 g of lactose, dissolve stilbene glycoside, sodium metabisulfite, sodium chloride, mannitol and lactose with an appropriate amount of water for injection, filter, and adjust pH to 6.7-7.4, sterilized by 0.22μm filter membrane, diluted with sterile water for injection to 1000ml, filled in 10ml brown glass bottles, 4ml per bottle, freeze-dried to obtain the finished product.

Embodiment 2

[0053] Embodiment 2 Dropping pills

[0054] Weigh 180g of stilbene glycosides, add PEG4000 2Kg as a substrate, and appropriate amount of liquid paraffin as a coolant; the liquid temperature is 50°C, the dropping speed is 12 drops per minute, the drop distance is 4.5cm, the length of the cooling column is 30cm, and the inner diameter of the drop opening is 2.5cm , coolant temperature 0°C (ice-water bath).

Embodiment 3

[0055] Example 3 Injection

[0056] Weigh 50g of stilbene glycosides, add 9g of sodium chloride, add water for injection to 1000ml, adjust the pH to 7.0-7.4, filter, fill the filtrate into ampoules of 2, 5 or 10ml, and sterilize at 100°C for 30min to obtain injection liquid.

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Abstract

The invention relates to applications of stilbene glucoside in preparation of medicament for improving an intestinal mucosal barrier function. The invention aims at providing applications of stilbene glucoside and pharmaceutically acceptable salt or esters thereof in preparation of a medicament for improving the intestinal mucosal barrier function. The stilbene glucoside can effectively improve the endotoxin translocation, the content of LPS can be reduced nearly by 25%. Therefore, the stilbene glucoside has the function of improving intestinal mucosal barrier function and has a good development prospect.

Description

technical field [0001] The present invention relates to the study of drug activity, in particular to the regulating effect of stilbene glycoside on intestinal mucosal barrier function. Background technique [0002] With the understanding of the homology of liver and intestinal anatomy, the interaction of metabolism and immune correlation becoming more and more clear, the concept of liver-gut axis (liver-gut-axis) has been gradually proposed and accepted. The concept of "liver-gut axis" was formally proposed by Marshall in 1998, which clarified the close relationship between the liver and the intestinal tract, substances, cells, cytokines, etc., which regulate and influence each other through the inherent portal system. Depicted the anatomical connection and functional interaction between liver and intestine, especially the enterohepatic circulation of cytokines and cells. A large number of subsequent studies have shown that intestinal mucosal barrier abnormalities are of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P1/04
Inventor 赵荣华毛晓健俞捷林佩顾雯贺森韩明暖
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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