Separation and purification method of valine

A purification method and valine technology, which are applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of difficult separation, unsatisfactory separation effect and valine yield, etc., so as to reduce sewage , Obvious effect of energy saving

Active Publication Date: 2015-05-06
SANDA FILM SCI & TECH XIAMEN +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

It is difficult to remove miscellaneous acids in production. Miscellaneous acids such as lysine and alanine can be removed through repeated concentration and crystallization, while leucine needs to be removed through the difference in the resolution speed of leucine and valine during the separation process. Removal, its separation properties are similar to chromatographic separation, the separation is difficult, and it is a key point in the production of pharmaceutical-grade valine products. The separation effect and valine yield of the existing technology are still not ideal

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  • Separation and purification method of valine

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Embodiment 1

[0031] A method for separating and purifying valine, comprising the steps of:

[0032] (1) After the valine fermentation broth is filtered through a plate frame, the filtrate is obtained, the pH of the filtrate is 2.0-2.5, the valine content is 2-3%, and the leucine content is 0.5-1.5%. , send the filtrate to such as figure 1 In the feed zone of the continuous moving bed of the cation exchange resin column rotating from right to left shown, the rotation period is 32h;

[0033] (2) if figure 1 As shown, the cation exchange resin column of the continuous moving bed is divided into feed area, water washing area, backwash area, product top water area, first analysis area, second analysis area, analysis liquid recovery area, The acid regeneration area and the washing acid area collect the analysis solution of the first analysis area and the second analysis area, which are used to produce pharmaceutical grade valine products and food grade valine products respectively;

[0034] T...

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Abstract

The invention discloses a separation and purification method of valine. The separation and purification method comprises the following steps: (1) performing frame filtering on valine fermentation liquid to obtain filtered solutions, and feeding the filtered solutions into a cation exchange resin column, which rotates from right to left, of a continuous moving bed; (2) sequentially dividing the cation exchange resin column of the continuous moving bed into a feeding area, a material washing area, a back-washing area, a product water ejection area, a first analyzing area, a second analyzing area, an analyzing solution recovery area, an acid regeneration area and a washing acid area from right to left, and collecting the analyzing solutions of the first analyzing area and the second analyzing area and applying the analyzing solutions to production of medicine-level valine products and food-level valine products. The yield of the valine obtained by using the method can reach about 98 percent.

Description

technical field [0001] The invention belongs to the technical field of fermentation amino acid separation, and in particular relates to a method for separation and purification of valine. Background technique [0002] Valine is one of the 20 kinds of amino acids that make up protein. Its chemical name is 2-amino-3-methylbutyric acid. It belongs to branched-chain amino acids and is also 8 kinds of amino acids necessary for human body. The human body cannot produce valine itself and must be supplemented through dietary sources. Its natural food sources include grains, dairy, shiitake, mushrooms, peanuts, soy protein, and meat. Valine plays a very important role in metabolism because of its special structure and function. It works together with two other high-concentration amino acids (isoleucine and leucine) to promote normal body growth, repair tissues, and regulate blood sugar , and provide the required energy. When participating in strenuous physical activity, valine can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/08C07C227/40
Inventor 何阿云林雄水黄智陶林丽华蓝伟光
Owner SANDA FILM SCI & TECH XIAMEN
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