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Centrifugal-type detection platform and operating process thereof

A detection platform and centrifugal technology, applied in the direction of analysis materials, instruments, etc., can solve problems such as inability to provide accuracy, affect data interpretation, dosage of medicines, and impact on patients with chronic diseases, and achieve high accuracy and reliability. The effect of less reagent volume and simple operation

Active Publication Date: 2015-05-06
常德普施康生物科技有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0003] At present, several portable detection instruments are available on the market to provide rapid detection functions, such as instruments suitable for blood fat detection, or instruments suitable for coagulation time. However, although the above-mentioned portable instruments use whole blood as a sample, the above-mentioned During the detection process, the instrument relies on capillary phenomenon to transport the whole blood sample or uses diffusion to achieve the purpose of mixing
Therefore, it cannot provide good detection accuracy, which in turn affects data interpretation, drug dosage, and even long-term treatment effects, which has a huge impact on patients with chronic diseases.

Method used

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  • Centrifugal-type detection platform and operating process thereof
  • Centrifugal-type detection platform and operating process thereof
  • Centrifugal-type detection platform and operating process thereof

Examples

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Embodiment 1

[0050] This embodiment takes the prothrombin time test as an example. The amount of the whole blood sample required in this embodiment is 7 microliter (μl), and inject it and 4 μl of procoagulant reagent into the sample storage tank 311 and the reagent storage tank 312 respectively. The operator can control and drive the transmission device 2, which is the motor, to drive the microfluid disc 3 to rotate through the computing device 5, which is the computer software included in the computer, and the centrifugal force generated makes 7 μl of whole blood transferred to the pouring tank 313 4 μl of procoagulant reagent is sent to the detection area 3141 for temporary storage. The centrifugal force generated by the continuous rotation of the motor can separate the whole blood into a plasma (serum) within 1 minute. 2 μ of the plasma (clear) is quantitatively poured into the mixing tank 314 due to the alternate rotation of the microfluidic disc 3 clockwise and counterclockwise. The...

Embodiment 2

[0053] This embodiment is blood fat detection, and the inspection system collects the patient's whole blood sample by the hospital. 7 μl of the whole blood sample and 68 μl of reagent are injected into the sample storage tank 311 and the reagent storage tank 312 respectively. The operator can control and drive the motor through the computer software to rotate the microfluidic disk 3 , and the centrifugal force generated makes the whole blood sample be sent to the pouring tank 313 , and the reagent is also sent to the detection area 3141 for temporary storage. The plasma (clear) and blood cells can be separated within 1 minute. 2 μl of the plasma (clear) is quantitatively poured into the mixing tank 314 due to the alternate rotation of the microfluidic disc 3 clockwise and counterclockwise. The microfluid disc 3 continuously rotates clockwise and counterclockwise, and 2 μl of the plasma (clear) and the reagent can be quickly and uniformly mixed within 1 second to form the mixe...

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Abstract

The invention discloses a centrifugal-type detection platform, which comprises a microfluid optical disc, a transmission device capable of controlling rotation and the rotation mode of the microfluid optical disc, a sensing apparatus used for sensing reaction of the microfluid optical disc, and an operation apparatus used for receiving a reaction signal and generating a result. The transmission device drives the microfluid optical disc to rotate for generating centrifugal force, thereby a sample or a reagent can be transmitted, the sample is separated, or the microfluid optical disc is driven for alternative rotation by clockwise and anticlockwise directions, so that the separated sample enables quantitative decantation and is mixed with the reagent, and a purpose of rapid detection completion can be reached. According to the invention, at least a micro channel is placed in the microfluid optical disc, and comprises a sample storage groove, a reagent storage groove, a decantation tank, a mixing tank and a detecting zone.

Description

technical field [0001] The invention relates to a detection platform, in particular to a platform that can use whole blood samples and other samples to perform centrifugal detection immediately and rapidly. Background technique [0002] Patients with chronic diseases such as hypertension, heart disease, diabetes, etc. need to monitor the values ​​of various biochemical, blood, serum and other test items in their blood for a long time and regularly. Every time the patient has to go to the doctor to draw blood, and then register to get the test results after the follow-up. The process is time-consuming and tiring. possible risk of injury during the process. As a result, patients may reduce the number of visits to the doctor, resulting in the inability to control the development of the disease and the inability to monitor the patient's medication status. Or the biochemical or blood test results of inpatients or even emergency patients can be known in a short time, but it ofte...

Claims

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Application Information

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IPC IPC(8): G01N35/02
Inventor 施志欣颜志宏林堃维林佳慧
Owner 常德普施康生物科技有限公司
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