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Preparation method for simethicone

A technology of simethicone and simethicone, which is applied in the field of preparation of simethicone, can solve the problems of large power consumption, etc., and achieve the effects of saving production time, good defoaming effect, and narrow particle size distribution

Inactive Publication Date: 2015-05-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the holding time is about 15 hours, the power consumption is large, and the metal ions in the container, such as iron, will migrate into the reaction solution.

Method used

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  • Preparation method for simethicone
  • Preparation method for simethicone
  • Preparation method for simethicone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method for Simethicone, comprising the following steps:

[0026] Step (1): Take 945g of simethicone, add 55g of silicon dioxide, keep warm at 55°C, stir to disperse evenly, and set aside.

[0027] Step (2): Get above-mentioned mixed solution, place in the hopper of Rannie 5 / Gaulin 5 type high-pressure homogenizer (Germany APV company), pressure is 55MPa, and pressure holding time is 60 minutes; Emit feed liquid, obtain final product.

Embodiment 2

[0029] A preparation method for Simethicone, comprising the following steps:

[0030] Step (1): Take 945g of simethicone, add 55g of silicon dioxide, keep warm at 65°C, stir to disperse evenly, and set aside.

[0031] Step (2): Get above-mentioned mixed solution, place in the hopper of Rannie 5 / Gaulin 5 type high-pressure homogenizer (Germany APV company), pressure is 95MPa, and pressure holding time is 30 minutes; Emit feed liquid, obtain final product.

Embodiment 3

[0033] A preparation method for Simethicone, comprising the following steps:

[0034] Step (1): Take 945g of simethicone, add 55g of silicon dioxide, keep warm at 75°C, stir to disperse evenly, and set aside.

[0035] Step (2): Get above-mentioned mixed solution, place in the hopper of Rannie 5 / Gaulin 5 type high-pressure homogenizer (Germany APV company), pressure is 85MPa, and holding time is 40 minutes; Emit feed liquid, obtain final product.

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Abstract

The invention discloses a preparation method for simethicone. In a preparation process, a high-pressure homogenizing machine is used, a homogenizing pressure is 50-100 MPa, and the pressure maintaining time is 20-60 minutes. The preparation method comprises the following steps: mixing and stirring silicon dioxide and dimeticone, and then adding the mixed solution to the high-pressure homogenizing machine to be homogenized so as to obtain the dimeticone. The method solves the problem of energy consumption, and the production cost is reduced; besides, the silicon dioxide can be dispersed in the dimeticone in the form of nanometer granules, and the dispersed state of the silicon dioxide is increased; in the preparation process, high temperature is not used, so that the thermolysis for the dimeticone is reduced, the content of heavy metal such as lead is reduced, toxic and side effects on a human body are reduced, and the problem that the dispersibility of the silicon dioxide and the stability of the dimeticone are difficult to consider in industry is solved.

Description

technical field [0001] The invention relates to a preparation method of simethicone, which belongs to the field of medicine synthesis. Background technique [0002] Simethicone (chemical structure see Figure 7 ) is a mixture containing 4% to 7% of silicon dioxide and simethicone with a viscosity of 20 to 400cps, and is an off-white to milky white viscous liquid, wherein the function of silicon dioxide is to enhance the defoaming effect of simethicone ( Translated by Li Dakui. Martindale Drug Encyclopedia (35th Edition of the original work) Beijing: Chemical Industry Press, 2008:1398). Experiments on rats have shown that to eliminate the same air bubbles, simethicone needs 750mg, silicon dioxide is 80mg, and simethicone is only 5mg (J Pharm Pharmacol.1973,25(11):859-863). Oral simethicone can reduce the surface tension of air bubbles in the gastrointestinal tract, make the air bubbles merge and rupture, and is clinically used to improve dyspepsia or gastroesophageal reflux ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L83/04C08K3/36A61K47/34A61K47/04
Inventor 翟光喜汪洋
Owner SHANDONG UNIV
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