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External composition for relieving pain of hyperplasia of mammary glands

A technology of external composition and extract, applied in the direction of drug combination, non-central analgesic, plant raw materials, etc., can solve the problems of slow onset of effect, many side effects, large dosage of traditional Chinese medicine, etc., and achieve lower concentration and lower oxidative stress Emotional relieving effect of agitation, restlessness and tension

Active Publication Date: 2015-05-27
GUANGZHOU KEYGENES MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Since most of the products currently used for breast hyperplasia and pain relief are taken orally, there are many side effects when taking western medicine directly, while traditional Chinese medicine takes a large amount and has a slow onset of effect

Method used

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  • External composition for relieving pain of hyperplasia of mammary glands
  • External composition for relieving pain of hyperplasia of mammary glands
  • External composition for relieving pain of hyperplasia of mammary glands

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0026] Embodiments 1 to 3 provide a kind of cream for external use for breast hyperplasia and pain relief, and its formula is shown in the following table 1 (each component in the table is a percentage by weight, and the sum of the percentages by weight of each component in the formula is 100%) :

[0027] Table 1

[0028]

[0029]

[0030] Embodiments 1-3 weigh each component according to the formula shown in Table 1, and then prepare according to the following steps:

[0031] Put polyethylene glycol-7 stearate, stearyl alcohol, Tween, and Span into the emulsification pot, heat it at 65°C-75°C; Slightly heat the alcohol in an iron bucket to dissolve, filter, and keep warm at 65°C-75°C; after the material in the emulsification pot melts and reaches the temperature, then homogeneously emulsify for 2-6 minutes; Alcohol solution, clove oil, zedoary oil, angelica oil, sweet almond oil and chamomile oil, after emulsification for 4-8 minutes, close the homogenization, add phe...

Embodiment 4～6

[0033] Embodiment 4~6 provides a kind of external emulsion that is used for mammary gland hyperplasia and pain relief, and its formula is as shown in the following table 2 (each component in the table is weight percentage, and the weight percentage sum of each component in the formula is 100%):

[0034] Table 2

[0035] components

Example 4

Example 5

Example 6

Danshen Extract

0.2％

0.7％

0.5％

clove oil

0.6％

0.2％

0.4％

Curcuma Oil

0.6％

1.2％

0.9％

Angelica Oil

1.8％

0.4％

1.2％

sweet almond oil

2.2％

5.5％

4％

Chamomile oil

1.1％

2.2％

1.6％

Span 60

3.2％

4.2％

3.5％

Tween 80

5.5％

4.2％

5％

[0036] carbomer

0.2％

0.1％

0.1％

Sodium hyaluronate

0.1％

0.2％

0.2％

Glycerin

6％

7％

7％

Butanediol

4.5％

5.5％

5％

Phenoxyethanol

0.6％

0.9％

...

Embodiment 7

[0042] Efficacy research

[0043] 1. Heat radiation tail flick pain test in rats

[0044] Experimental Materials

[0045] (1) Drugs

[0046] The external composition group of the present invention: the external composition of Example 1 of the present invention is used.

[0047] Positive control group 1: the medicine used is prepared according to the method of Example 1, and its formula is basically the same as that of Example 1. Sweet almond oil and chamomile flower oil, all the other components and contents are basically the same as in Example 1, and will not be repeated.

[0048] Positive control group 2: the medicine used is prepared according to the method of Example 1, and its formula is basically the same as that of Example 1. Sweet almond oil and chamomile flower oil, all the other components and contents are basically the same as in Example 1, and will not be repeated.

[0049] Blank control group: according to the method of Example 1, remove the medicinal ingredi...

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PUM

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Abstract

The invention provides an external composition for relieving pain of hyperplasia of mammary glands. The formula of the external composition sequentially comprises the following medical components in percentage by weight: 0.2-2 percent of salviae miltiorrhizae extract, 0.2-6.6 percent of clove oil, 0.6-5.8 percent of zedoary turmeric oil, 0.4-1.8 percent of angelica oil, 2.2-21 percent of sweet almond oil and 1.1-3.2 percent of chamomile oil. The external composition provided by the invention is simple in medicinal components and convenient to use and has a good effect of relieving breast pain. The external composition can simultaneously relieve the restless mood of patients caused by the pain, so that the psychological burdens of the patients suffering from the breast pain can be alleviated.

Description

technical field [0001] The invention relates to an external skin care product, in particular to an external composition for relieving the pain of mammary gland hyperplasia. Background technique [0002] Mammary gland hyperplasia is a common breast disease in women of childbearing age, accounting for more than 75% of all breast diseases. The peak age of its onset is 25-55 years old, and the incidence rate of women over 30 years old reaches more than 90%. [0003] The clinical manifestation of cyclomastopathy mainly contains mastalgia and lump in breast. The pain of breast hyperplasia is due to individual differences, different stages of lesions, and different severity of lesions, so the nature and degree of breast pain are also different. Generally, it is mainly distending pain, and there is also tingling pain, pulling pain or dull pain, which can involve one or both breasts. The pain is often cyclical, that is, it is aggravated before menstruation and relieved or disappear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P15/14A61P29/00
Inventor 周若鹏
Owner GUANGZHOU KEYGENES MEDICAL TECH
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