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MR system and method for detecting metabolites

A metabolite and substance spectrum technology, applied in the field of MR systems and methods for detecting metabolites, can solve problems such as background signal pollution, unreliable and inaccurate results, and achieve low background signal pollution, high signal-to-noise ratio, The effect of robust detection

Inactive Publication Date: 2015-05-27
KONINKLJIJKE PHILIPS NV
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  • Claims
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Problems solved by technology

However, even with its greater sensitivity, the results of the J-difference technique are often unreliable and / or inaccurate due to background signal contamination of the signal spectrum due to, for example, Cr and MM concentrations present at In the volume of interest (VOI) being sampled (e.g., a human skull)

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  • MR system and method for detecting metabolites
  • MR system and method for detecting metabolites
  • MR system and method for detecting metabolites

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Embodiment Construction

[0020] The following is a description of illustrative embodiments which, when taken in conjunction with the following figures, will demonstrate the above-mentioned features and advantages, as well as other advantages. In the following description, illustrative details such as architectures, interfaces, technologies, element attributes, etc. are set forth for purposes of explanation and not limitation. However, other embodiments that depart from these details will still be understood to be within the scope of the claims and will be apparent to one of ordinary skill in the art. Moreover, for the purpose of clarity, detailed descriptions of well-known devices, circuits, tools, techniques and methods are omitted so as not to obscure the description of the present system. It should be expressly understood that the drawings are included for illustrative purposes and do not represent the scope of the present system. In the drawings, the same reference numbers in different drawings m...

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Abstract

A magnetic resonance (MR) system for detecting concentrations one or more metabolites in a volume of interest (VOI), the system including at least one controller which: may apply to the VOI a multiple quantum filter (MQF) Point Resolved Spetroscopy (PRESS) sequence comprising first and second 90º RF pulses, a third 90º RF pulse,first and second 180º adiabatic pulses, and a composite dual-band delay alternating with nutation for tailored excitation (DANTE) pulse train having a plurality of N block pulses (N being an integer), the DANTE pulse train situated in time between the first and second 90º RF pulses, the first and second 180º adiabatic pulses situated in time after third 90º RF pulse; detect MR Free Induced Decay (FID)signal emitted from the VOI; and / or reconstruct the detected MR FID signal to obtain metabolite spectrum information.

Description

technical field [0001] Exemplary embodiments of the present invention can provide medical diagnostic imaging including a magnetic resonance (MR) system for detecting one or more metabolites (e.g., gamma-aminobutyric acid (GABA)), and more In particular, it relates to an automated in vivo metabolite detection system and method of operation thereof. Background technique [0002] Magnetic resonance spectroscopy (MRS) is a form of magnetic resonance imaging (MR) and can be used to measure the concentration of metabolites in a test subject (eg, mammal, etc.). One of these metabolites is known to be gamma-aminobutyric acid (GABA), and gamma-aminobutyric acid is often referred to as the major inhibitory neurotransmitter in the central nervous system of mammals (eg, humans). Unfortunately, GABA is frequently implicated in several neuropsychiatric disorders in humans (eg, Parkinson's disease). Typically, the concentration of GABA in normal human skull (eg, human brain) is about 1 m...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/485G01R33/46A61B5/055G01R33/483
CPCA61B5/055G01R33/4616G01R33/4833G01R33/485A61B5/4058G01R33/465
Inventor B·杨
Owner KONINKLJIJKE PHILIPS NV
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