MR system and method for detecting metabolites

A metabolite and substance spectrum technology, applied in the field of MR systems and methods for detecting metabolites, can solve problems such as background signal pollution, unreliable and inaccurate results, and achieve low background signal pollution, high signal-to-noise ratio, The effect of robust detection
CN104662433AInactive Publication Date: 2015-05-27KONINKLJIJKE PHILIPS NV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KONINKLJIJKE PHILIPS NV
Publication Date
2015-05-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

A magnetic resonance (MR) system for detecting concentrations one or more metabolites in a volume of interest (VOI), the system including at least one controller which: may apply to the VOI a multiple quantum filter (MQF) Point Resolved Spetroscopy (PRESS) sequence comprising first and second 90Âș RF pulses, a third 90Âș RF pulse,first and second 180Âș adiabatic pulses, and a composite dual-band delay alternating with nutation for tailored excitation (DANTE) pulse train having a plurality of N block pulses (N being an integer), the DANTE pulse train situated in time between the first and second 90Âș RF pulses, the first and second 180Âș adiabatic pulses situated in time after third 90Âș RF pulse; detect MR Free Induced Decay (FID)signal emitted from the VOI; and / or reconstruct the detected MR FID signal to obtain metabolite spectrum information.
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Description

technical field

[0001] Exemplary embodiments of the present invention can provide medical diagnostic imaging including a magnetic resonance (MR) system for detecting one or more metabolites (e.g., gamma-aminobutyric acid (GABA)), and more In particular, it relates to an automated in vivo metabolite detection system and method of operation thereof. Background technique

[0002] Magnetic resonance spectroscopy (MRS) is a form of magnetic resonance imaging (MR) and can be used to measure the concentration of metabolites in a test subject (eg, mammal, etc.). One of these metabolites is known to be gamma-aminobutyric acid (GABA), and gamma-aminobutyric acid is often referred to as the major inhibitory neurotransmitter in the central nervous system of mammals (eg, humans). Unfortunately, GABA is frequently implicated in several neuropsychiatric disorders in humans (eg, Parkinson's disease). Typically, the concentration of GABA in normal human skull (eg, human brain) is about 1 m...

Claims

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