Method for improving quality of Ganmaoling granule intermediates

A technology for Ganmaoling and intermediates, which is applied in the field of production of traditional Chinese medicine extracts, can solve the problems of easy loss of active ingredients, high concentration temperature, long concentration time, etc., and achieves improved quality of Ganmaoling granules intermediates, clear control indicators, and reasonable design. Effect

Active Publication Date: 2015-06-03
华润三九(枣庄)药业有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Concentration of traditional Chinese medicine extract is one of the important processes of traditional Chinese medicine pharmacy. At present, there are common problems of high concentration temperature, long concentration time and easy loss of active ingredients.

Method used

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  • Method for improving quality of Ganmaoling granule intermediates
  • Method for improving quality of Ganmaoling granule intermediates
  • Method for improving quality of Ganmaoling granule intermediates

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Ganmaoling traditional Chinese medicine extract: according to the prescription of Ganmaoling, weigh 982g of Sanchaku, 492g of wild chrysanthemum, 654g of calendula silver plate, 1472g of Gangmei, a total of 3600g, add 25000g of water as a solvent, heat to a slight boil, and decoct 3 times, 2 hours each time, combine the extracts three times, filter, take samples and determine the content of mongolin in them, and the extracts are used for concentration experiments.

Embodiment 2

[0024] Measure 3000 mL of the extract prepared in Example 1, put it in a rotary evaporator concentrator, evaporate and concentrate in a constant temperature water bath, heat to boil, concentrate and dehydrate. Different concentration temperatures and times are determined according to the experimental design. The set concentration temperatures are 70° C., 85° C. and 100° C. respectively, and the concentration time range is 1-10 hours, and the more preferred time range is 1-5 hours. When the extract is concentrated to the specified time, stop the rotary evaporator, transfer the concentrated solution to a 1000mL volumetric flask after cooling down on the rotary evaporator, and distill it to volume for later use.

[0025] The concentration temperature is determined by adjusting the vacuum degree of the system and the temperature of the heating water bath. The corresponding vacuum degree of 70°C is -90±5KPa, and the corresponding vacuum degree of 85°C is -55±5KPa. Sampling and analy...

Embodiment 3

[0030] As in the evaporation concentration method in Example 2, three temperatures were set for fine-tuning concentration experiments, namely 70°C, 85°C and 100°C, and the concentrate was returned to the system to maintain material balance. The heating time of the material was extended to more than 5 hours, during which the concentrated solution was sampled and analyzed every hour to investigate the retention rate of mongoside. Three experiments were performed in parallel for each group.

[0031] The experimental results are listed in Table 1.

[0032]

[0033] In order to determine the reaction order of thermal degradation of mongoside, the ln c plotted against time t, see appendix figure 1 .

[0034] attached figure 1 It was shown that the thermal degradation process of mongoside conformed to the typical first-order chemical reaction characteristics, that is, the concentration of mongoside changed with time as an exponential function. Where k is the reaction rate...

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Abstract

The invention provides a method for improving the quality of Ganmaoling granule intermediates. The method comprises the following steps: characterizing a degradation rule of linarin by adopting a reaction kinetic model, acquiring a quantitative relationship among the temperature, time and linarin content changes, proposing a principle of taking the linarin retention rate as a quality control index, and setting material retaining time according to the concentration temperature to ensure the transfer rate of an index component namely linarin of the Ganmaoling granule intermediates. The method provided by the invention is reasonable to design, reveals that linarin degradation reaction can meet the characteristics of first-order reaction in a concentration process, is clear in control index, and has practical operability; a technical method for effectively controlling quality indexes of the Ganmaoling granule intermediates can be provided for industrial production, and the technology upgrading of large varieties of traditional Chinese medicines can be benefited; and a technological idea based on process validity period control can be proposed, and the target of improving the quality of the Ganmaoling granule intermediates can be achieved.

Description

technical field [0001] The invention belongs to the field of production of traditional Chinese medicine extracts, and relates to a method for improving the quality of Ganmaoling granule intermediates. Background technique [0002] Ganmaoling Granules is a well-known large variety of cold medicine in China, with annual sales exceeding one billion yuan. It is a Chinese patent medicine composed of four traditional Chinese medicines such as Sanchaku, wild chrysanthemum, gang plum, calendula silver plate and three chemical medicines. It is a model of combining traditional Chinese and Western medicine to treat diseases. Ganmaoling has antipyretic and analgesic effects, and is clinically used to treat headache, fever, nasal congestion, runny nose, and sore throat caused by colds. The four traditional Chinese medicines in the prescription all have heat-clearing and detoxifying effects, and are widely used in the treatment and prevention of colds and other febrile diseases, with rem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/16A61P11/00A61P31/12G01N30/02
Inventor 王龙虎邓海欣毛佩芝栾连军刘雪松
Owner 华润三九(枣庄)药业有限公司
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