Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition

A technology for synovitis and knee joints, applied in the field of traditional Chinese medicine composition for treating knee joint synovitis and its preparation, can solve the problems of synovial tissue regeneration and repair ability reduction, troubles, etc., and achieve good social value and economic benefits , easy to use, and highly targeted effects

Inactive Publication Date: 2015-06-03
青岛申达高新技术开发有限公司
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the treatment of synovitis is mainly to regulate the microcirculation system. As long as the microcirculation is unblocked, the water circulation will disappear, and the inflammation will also be relieved. Water pumping and injection w...

Method used

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  • Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0085] The preparation method of capsule of the present invention:

[0086] Atractylodes 1500g, Poria cocos 1500g, Zhishouwu 1500g, Gentiana 1500g, Rehmannia glutinosa 1500g, Dipsacus 1500g, Safflower 1500g, Achyranthes bidentata 1500g, Guizhi 1500g, Duhuo 1500g, Sangjisheng 1500g, Cinnamon 1500g, Polygonum cuspidatum 1500g, white Mustard Seed 1500g, Fangfeng 1500g, Shenjincao 1500g, Drynaria 1500g, Salvia miltiorrhiza 1500g, Geranium 1500g, Radix Paeoniae Alba 1500g, Panax notoginseng 1500g, Wood Beetle 1500g, Guanzhong 1500g, first cut all raw materials into coarse particles, Then put it into ethanol, soak for more than 2 hours, add respectively 8 times and 6 times of the total mass of the raw material drug, and heat and extract twice, and the extraction time is 2 hours and 1 hour; combine the 2 extracts, extract Through tube centrifugation, the centrifugate was obtained, and the centrifugate was absorbed by D 101 macroporous resin, washed with water to remove impurities, an...

experiment example 2

[0106] Experimental example 2: Cumulative toxicity test:

[0107] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

experiment example 3

[0108] Experimental Example 3: Results of Acute Percutaneous Toxicity Test

[0109] The medicinal compound preparation for external use of the present invention has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Accordingly, the acute percutaneous toxicity test was first carried out to observe whether the drug's acute percutaneous toxicity to rats is actually non-toxic.

[0110] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for later use.

[0111] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Provincial Academy of Traditional Chinese Medicine, male and female, weighing 180-220g, first-class animals (Yidongzi No. 08-25), and the source of feed was the same as above. Animal room environment: ...

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Abstract

The invention provides a traditional Chinese medicine composition for treating gonarthromeningitis. An internal medicine is prepared from the following raw materials: rhizoma atractylodis, poria cocos, radix polygoni multiflori preparata, gentiana macrophylla, radix rehmanniae preparata, dipsacus asperoids, flos carthami, achyranthes bidentata, cassia twig, radix angelicae pubescentis, loranthus parasiticus, cinnamon, polygonum cuspidatum, semen brassicae, divaricate saposhnikovia root, common clubmoss herb, rhizoma drynariae, salviae miltiorrhizae, erodium stephanianum willd, white paeony root, panax notoginseng, ground beeltle and cyrtomium fortune; and an external medicine is prepared from the following raw materials: myrrh, olibanum, dipsacus asperoids, notopterygium, flos carthami, homalomena occulta, tripterygium glycosides, fennel, radix aconiti preparata, scorpio, garden balsam stem, polygonum cuspidatum, semen strychni, arisacma consanguineum and zaocys dhumnade. The traditional Chinese medicine composition is capable of nourishing yin, clearing heat, removing dampness, dredging collaterals and removing pain by combination of internal administration and external application, and is good at activating blood circulation to remove stasis, expelling wind, clearing away cold, reducing swelling, relieving pain and strengthening tendons and bones. The traditional Chinese medicine composition has the advantages of being convenient to dose, thorough to ill part, high in targeting property, and low in cost; a medicine is easy to prepare; the traditional Chinese medicines are capable of treating both symptoms and root causes, are safe, effective and low in treatment cost; the traditional Chinese medicine composition is convenient to use, low in price and convenient to use; and good social value and economic benefits can be created.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating knee joint synovitis and a preparation method thereof. Background technique [0002] Knee synovitis, also known as knee synovitis, is a multiple disease. It is easy to cause the temporary or long-term partial loss of labor force of the patient, which is more harmful to the patient. At present, although there are many effective treatment methods, there are still many patients who cannot be cured. Especially some young and middle-aged patients have to bear many social and family responsibilities, and at the same time suffer from pain for a long time. [0003] Knee synovitis is often secondary to knee osteoarthritis in the elderly, mainly due to mechanical and biochemical stimulation of cartilage degeneration and bone hyperplasia, secondary to knee joint synovial edema, ex...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K36/8884A61K9/20A61K9/70A61K9/06A61P29/00A61P19/02A61P19/04
Inventor 不公告发明人
Owner 青岛申达高新技术开发有限公司
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