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Zizhi lactam a and its pharmaceutical composition and its application in pharmacy and food

A technology of Zizhi lactam and lactam, which is applied in the field of pharmaceutical technology and food, and can solve the problems of anti-chronic kidney disease and other problems that have not been seen

Inactive Publication Date: 2017-01-18
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor thinks that it may contain anti-chronic kidney disease active substances, but there is no relevant report on the compound involved in the present invention and its anti-chronic kidney disease in the prior art

Method used

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  • Zizhi lactam a and its pharmaceutical composition and its application in pharmacy and food
  • Zizhi lactam a and its pharmaceutical composition and its application in pharmacy and food
  • Zizhi lactam a and its pharmaceutical composition and its application in pharmacy and food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Separation and purification of compound 1:

[0023] Take 40kg of Ganoderma sinensis, pulverize it, extract it with 70% ethanol under reflux (3×130L×2h), combine the extracts and recover the solvent under reduced pressure to obtain a crude extract, suspend the crude extract in an appropriate amount of water, and then use Volumetric ethyl acetate was extracted three times, the combined extracts were concentrated under reduced pressure to obtain ethyl acetate extract (0.72kg), which was subjected to MCI gel CHP 20P column chromatography (MeOH: H 2 O, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10, 100:0), each solvent gradient is 1.5 times the column volume, according to Each part of 300mL collected 8 combined components; Component 3 (18g) was chromatographed through RP-18 column (MeOH: H 2 0, 20%-60%), TLC detection combined the same fraction of the spots to obtain 6 components (components 3.1-3.6). Fraction 3.3 (1.5 g) was separated by Sephadex LH-20 (MeOH) to ...

Embodiment 2

[0035] Any one of the compounds in Example 1 can be made into an injection solution after adding injection solvent according to the conventional method, finely filtering, potting and sterilizing.

Embodiment 3

[0037] Any one of the compounds in Example 1 was dissolved in sterile water for injection, filtered through a sterile funnel, subpackaged, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

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PUM

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Abstract

The invention provides a compound ganoderma sinense lactam A (+)- or (-)- Sinensilactam A [(+)-1 or (-)-1] with resistance value for chronic kidney disease or renal fibrosis, a preparation method of the compound, a pharmaceutical composition employing the compound as anactive ingredient, and an application of the compound in preparation of medicines for resisting the chronic kidney disease and / or renal fibrosis. Ganoderma sinense is a rare characteristic traditional Chinese medicine recorded in the Chinese pharmacopoeia and is wide in pharmacological action. A despinner is separated out; a pair of optical enantiomers is formed by chiral resolution; and the activity study proves that the ganoderma sinense lactam A is capable of inhibiting phosphorylation of a TGF-beta1-induced renal tubular epithelial cell Smad3, which means that the ganoderma sinense lactam A has the application prospect in preparation of medicines for resisting the chronic kidney disease and renal fibrosis.

Description

[0001] Technical field: [0002] The invention belongs to the fields of pharmaceutical technology and food, and in particular relates to shinozolactam A and its pharmaceutical composition, and its application in the preparation of medicine or health food for treating renal fibrosis or chronic kidney disease. [0003] Background technique: [0004] The inventor of this patent has a clear description in the published Chinese patent (publication number: CN 102153630A) about the hazards, pathological mechanism and drug research methods and principles of chronic kidney disease. Due to the influence of many factors such as drugs and diet, the incidence of chronic kidney disease has exceeded 10%. It is a reality that the incidence of chronic kidney disease is high and the awareness rate is low. When chronic kidney disease progresses to renal failure, it can only rely on kidney transplantation and hemodialysis. However, due to the lack of therapeutic drugs, there is no good interventio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D498/20A61K31/537A61P13/12A23L33/10A23L33/105
CPCA61K31/537C07B2200/13C07D498/20
Inventor 程永现罗奇邸磊田磊吕青
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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