Lubricant system for medical devices and application method thereof
A technology for medical devices and application methods, applied in lubricating compositions, medical science, surgery, etc., can solve problems such as inability to deform, and achieve the effects of excellent lubricating performance, wide application range, and easy realization and control.
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Embodiment 1
[0028] In Example 1, the performance of the injection needle surface lubricant with a double-coating structure is described and compared with the same product of an internationally renowned brand.
[0029] The test method of the national standard GB18671-2009 is used to test the lubrication effect after changing the needle coating material. The puncture material used in the test is a polyurethane film with a thickness of 0.35mm±0.05mm and a Shore (A) hardness of 85±10. This kind of film has the function of simulating human skin. Before the test, the polyurethane film should be placed at 22°C±2°C for more than 24 hours, and tested at the same temperature.
[0030] A portion of a continuous length of polyurethane film is clamped in a fixture in such a way that tension on the polyurethane film is avoided during clamping. The test needle is installed in the fixture, its axis is perpendicular to the surface of the polyurethane film, the needle point points to the center of the cir...
Embodiment 2
[0045] Example 2 adopts a single-coat structure, that is, only one layer of the organosiloxane compound of the present invention is coated on the surface of the needle.
[0046] Independently, according to the formulation of Table 3, the needle surface lubricant coating of the present invention was prepared as sample 3:
[0047] table 3
[0048]
[0049] The substances mentioned in Table 3 are mixed uniformly under the condition of moisture barrier after water removal and other conditions have been removed in a certain order, and then dissolved in CFC volatile solvents and mixed uniformly in an appropriate way. CFC volatile solvents account for 1% of the total mass. 92%.
[0050] The crosslinking agent in Table 3 is a mixture of ethyl silicate and ketoximosilane, and the molar ratio of the two is 3:1.
[0051] The lubricating effect of sample 3 was tested for puncture force in the same manner as in Example 1, and Table 4 shows the corresponding force.
[0052] Table 4
...
Embodiment 3
[0056] Example 3 According to the present invention, the coupling agent is used alone as the primer layer to perform the first step of dip coating on the needle, and then other parts of the coating are performed after the solvent evaporates.
[0057] Independently, according to the formulation in Table 5, the needle surface lubricant coating of the present invention was prepared as Sample 4.
[0058] table 5
[0059]
[0060] The coupling agent in Table 5 was treated and dissolved in a CFC volatile solvent, and the coupling agent accounted for 3%, as component C.
[0061] The other components in Table 5 are mixed uniformly under moisture-proof conditions in a certain order, then dissolved in CFC volatile solvents, and mixed uniformly in an appropriate manner. CFC volatile solvents account for 92% of the total mass, as component D .
[0062] The crosslinking agent in Table 5 is a mixture of ethyl silicate and ketoximosilane, and the molar ratio of the two is 3:1.
[0063]...
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Abstract
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