Quantum dots-fibroin gel fluorescence nanometer anti-fake material and preparation method thereof

Abstract

The invention relates to a preparation method of a quantum dot (QDs)-fibroin gel fluorescence nanometer anti-fake material, and belongs to the field of nanomaterials. The fluorescence nanometer anti-fake material contains an organic component and nanometer crystal grains, the organic component is fibroin gel, and the nanometer crystal grains are fluorescence quantum dots. The preparation method of the nanometer anti-fake material comprises the following steps: synthesizing fluorescence quantum dot particles, preparing the fibroin gel, and compounding the quantum dots with the fibroin gel to prepare the quantum dots-fibroin gel fluorescence nanometer anti-fake material. The nanometer anti-fake material has the advantages of good biocompatibility, high fluorescence intensity, stable fluorescence properties, diversified fluorescence color, simple preparation technology and convenient detection, and has important application prospect in the fields of biological imaging and anti-fake indication.

Description

technical field [0001] The invention relates to a quantum dot-silk fibroin gel composite nanomaterial, which belongs to the field of nanomaterials. Background technique [0002] Quantum dots (qμantμm dots, QDs) are three-dimensional clusters composed of a limited number of atoms, and the three dimensions of quantum dots are all on the order of nanometers. Specifically, quantum dots are semiconductor nanocrystal grains whose particle size is smaller than or close to the exciton Bohr radius, and are the transition state of semiconductor between molecules and crystals. It is mainly composed of II-VI or III-V elements, and has a regular atomic arrangement similar to bulk crystals. At present, most of the research is mainly on CdX (X=S, Se and Te) and so on. [0003] The particle size of quantum dots is generally 1-10nm. Due to the small particle size, electrons and holes are quantum confined, and the continuous energy band becomes a discrete energy level structure with molecul...

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Problems solved by technology

[0005] 1. It has a wide excitation wavelength range, and can be excited by excitation light of any wavelength less than 10nm, so that the same excitation light can be used to simultaneously excite multiple quantum dots, thereby emitting fluorescence of different colors; while organic The wavelength range of excitation light of fluorescent dyes is narrow, and excitation light of multiple wavelengths is required to excite various fluorescent dyes, which will bring a lot of inconvenience to practical work

[0006] 2. The emission peaks of quantum dots are narrow and symmetrical, with small overlap, and the emission spectrum peaks of quantum dots with uniform size present a Gaussian symmetric distribution; while the emission peaks of organic fluorescent dyes are wide and asymmetrical, and the tailing phenomenon is serious, which is difficult for analysis and detection. intractable problem

[0009] 5. The biocompatibility of quantum dots is good, especially after various chemical modifications, not only can specific coupling be carried out, but it is less harmful to biology, and it can also be used for biological labeling and detection. Jaiswal et al. used quantum dots to treat living cells Labeling, the quantum dot probe entering the cell does not affect the morphology and proliferation process of the cell, and the quantum dot fluorescence in the cell can still be seen after 12 days of culture (Nat Biotechnol, 2003, 21 (1), 47-51); while the organic Fluorescent dyes are generally more toxic and have poor biocompatibility

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