Selectively polymerizable compositions and methods of use in vivo

A composition and polymer technology, applied in the direction of drug combination, prosthesis, tissue regeneration, etc., can solve the problems of no application in dentistry, etc., achieve the effect of enhancing drug efficacy, reducing recurrent infection, and easy application

Active Publication Date: 2015-07-29
TULANE EDUCATIONAL FUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dentistry uses blue light polymerizable materials, but

Method used

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  • Selectively polymerizable compositions and methods of use in vivo
  • Selectively polymerizable compositions and methods of use in vivo
  • Selectively polymerizable compositions and methods of use in vivo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071]In laboratory tests, the precursor may include polyethylene glycol diacrylate having a molecular weight of 1000 or polyethylene glycol diacrylate having a molecular weight of 4000 purchased from Polysciences Inc. (Warrington, PA). Bovine serum albumin (BSA), tetramethylrhodamine conjugate can be purchased from Invitrogen Inc. (Eugene, OR).

[0072] Test drug incorporation and release. During the initial crosslinking process, BSA was loaded into the hydrogel. A pH 7.4, 10% w / v solution of BSA in PBS was prepared. A photocrosslinking solution of 10% w / v PEG in PBS containing 0.5% Irgacure 2959 photoinitiator was prepared. BSA was incorporated into the solution at 5 wt% relative to the macromer loading. The final solution was stirred at 350 rpm for 15 minutes. Pipette 200 µL into wells of a 96-well plate. Each construct was exposed to UV light for 55 seconds. The gel was immediately removed from the well using a spatula and placed in a separate vial containing 5ml of ...

Embodiment 2

[0074] In the clinic, one embodiment of the invention may include the following administrations. The patient can lie on their side with the ear under the microscope. This allows the doctor to view and manipulate the eardrum without taking up both hands. The physician at this point can administer the liquid prepolymer composition mixed with the desired medication. The composition can be instilled into the ear using a pipette, just as ear drops are administered. A doctor may only need tens of microliters of the composition to cover a piercing. Once the composition is added and covers the perforation, the physician can irradiate the composition with light where the hydrogel is desired. Although there is no need to withdraw the unused composition, excess composition can be removed by the physician at his preference using a pipette or some sort of absorbent. Now that all excess composition can be removed, any excess composition can be added to ensure that the perforation is cov...

Embodiment 3

[0076] In a surgical setting, one embodiment of the present invention may include optimizing surgical filling materials currently used for the middle ear. Before suturing the surgical wound, the liquid prepolymer composition already incorporated with the desired drug is dropped onto the filling material and polymerized with light. In addition to enhancing mechanical support, this embodiment would also impart certain antimicrobial and drug delivery properties not currently available to surgical filling materials, thereby enhancing postoperative outcomes.

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Abstract

Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.

Description

[0001] Cross References to Related Applications [0002] This application claims the priority of U.S. Provisional Patent Application No. 61 / 665,639, filed on June 28, 2012, entitled "SELECTIVELY POLYMERIZABLE HYDROGEL FOR USE AS A MULTI-PURPOSE SURGICAL SCAFFOLD WITH DRUG-DELIVERY CAPABILITIES", The entire contents of which are incorporated by reference in this application. Background technique [0003] In the United States alone, more than one million surgeries of pressure equalizing tubes (PETs) are inserted into the tympanic membrane (TM) each year. These tubes allow fluid from a middle ear infection to drain from the middle ear into the outer ear canal, reducing pain from the increased pressure. It is generally believed that chronic TM perforation occurs when PETs remain in TM for too long. Chronic TM perforation occurs in 1-5% when PETs remain in TM for 18 months or less. However, some patients require PETs for 2 years or more—the incidence of chronic TM perforation i...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/52A61L27/14A61L27/20
CPCA61N5/062A61L2430/14A61L27/20A61K38/385A61L27/56A61L27/14A61L27/54A61L27/52A61P27/16C08L5/08
Inventor 杰西·兰尼伊莱恩·霍恩-兰尼帕拉斯图·胡沙赫拉夫迈克尔·摩尔
Owner TULANE EDUCATIONAL FUND
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