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Application of traditional Chinese medicine combination in preparation of drug for treating alcoholic fatty liver

A technology for alcoholic fatty liver disease and composition, which is applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problem that drugs need to be studied, and achieve the effect of relieving hepatomegaly, preventing liver fibrosis and good therapeutic effect

Inactive Publication Date: 2015-08-12
WUHAN KANGLE PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0003] Therefore, drugs for the treatment of alcoholic fatty liver remain to be studied

Method used

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  • Application of traditional Chinese medicine combination in preparation of drug for treating alcoholic fatty liver
  • Application of traditional Chinese medicine combination in preparation of drug for treating alcoholic fatty liver
  • Application of traditional Chinese medicine combination in preparation of drug for treating alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] Give Kunming mice 50% alcohol by intragastric administration for 3 weeks to establish a mouse model of alcoholic fatty liver. Rat blood, liver tissue homogenate, organs, pathological sections and other indicators were used to evaluate the pharmacodynamic effects of the tested drug on alcoholic fatty liver and to compare its characteristics or advantages with similar drugs.

[0047] 1. Experimental materials

[0048] Animals: 80 Kunming mice, SPF grade, weighing 18-22 g, half male and half male, provided by Hunan Slack Jingda Experimental Animal Co., Ltd., animal license number: SCXK (Xiang) 2013-0004.

[0049] Instruments: homogenizer, centrifuge, 96-well plate, 1.5ml Eppendorf tube, 5ml Eppendorf tube, 10ml Eppendorf tube, weighing balance, surgical instruments, microplate reader, light microscope.

[0050] Reagents and drugs: Anhydrous ethanol, formaldehyde, provided by Sinopharm Chemical Reagent Co., Ltd.; Compound Yiganling, provided by China Resources Double Crane...

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Abstract

The invention discloses a drug combination. The drug combination comprises liquorice and white peony root and is used for treating alcoholic fatty liver. The drug combination has good curative effect on alcoholic fatty liver and can play a role in protecting liver and preventing liver fibrosis.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for treating alcoholic fatty liver. Background technique [0002] The liver is an important organ of the human body, and it is also an important immune organ of the body. After various pathogenic factors act on the liver tissue, they can directly lead to different degrees of liver cell damage. Alcoholic liver disease (ALD) is a toxic liver disease characterized by hepatic steatosis, inflammatory cell infiltration, and even fibrosis caused by long-term heavy alcohol intake. According to statistics, the incidence of alcoholic fatty liver among alcoholics in our country is about 20%. Alcoholic liver disease has become the second role after viral hepatitis liver diseases such as hepatitis A and hepatitis B. [0003] Therefore, drugs for the treatment of alcoholic fatty liver re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P1/16
Inventor 王学海江书银许勇曹儒宾李莉娥秦和平黄璐杨仲文刘世勇余通黄天赐杨成兵何水英尹海龙冯芸杨婷谢长于静肖强
Owner WUHAN KANGLE PHARMA
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