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A kind of method for preparing glycolide and cracking device thereof

A glycolide and pyrolysis kettle technology, which is applied in the field of biomedical materials and synthesis technology, can solve the problems of increasing costs and energy waste, and achieve the effects of environmental protection, cost saving, and uniform molecular weight

Active Publication Date: 2018-06-15
WATER CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this kind of method needs to heat the inert gas, which increases the cost and energy waste

Method used

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  • A kind of method for preparing glycolide and cracking device thereof
  • A kind of method for preparing glycolide and cracking device thereof
  • A kind of method for preparing glycolide and cracking device thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the making of polyglycolic acid cracking device

[0017] Made of stainless steel, according to the attached figure 1 The structure shown makes a polyglycolic acid pre-cracking device with a volume of 10 liters.

Embodiment 2

[0018] Embodiment 2: the precondensation of glycolic acid

[0019] In the glycolic acid precondensation device, add 6 kg of glycolic acid through the feeding funnel, then add 5 grams of stannous octoate, heat up to 100 ° C for 1 hour; then heat up to 140 ° C for 1 hour, and at the same time vacuum 20Kpa; continue to heat up React at 200°C for 0.5 hours, then reduce the vacuum pressure to 10Kpa; after the reaction is completed, use the lifting and stirring method to pulverize the polyglycolic acid into powder.

Embodiment 3

[0020] Embodiment 3: Cracking of polyglycolic acid

[0021] Mix the polyglycolic acid powder obtained in Example 2 with 40 grams of antimony trioxide, then add it to the cracking device of polyglycolic acid through the feeding funnel, and batches are added during the feeding, and the amount of each feeding can be adjusted arbitrarily as required. Finished, the hopper is sealed, and the funnel piston is closed. Rapidly raise the temperature of the cracking kettle to 285°C by heating in an oil bath, and then open the funnel piston, so that the polyglycolic acid powder slowly enters the cracking kettle, and at the same time vacuumize, and the pressure drops to 2-5Kpa until the light yellow fraction is completely evaporated. The crude yield is greater than 90%.

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Abstract

The present invention discloses a new glycolide preparation method, wherein glycolic acid condensation polymerization adopts heating dewatering in stages, and a lifting stirring method is used in a condensation polymerization reaction kettle to crush polyglycolic acid into powder. According to the present invention, the novel polyglycolic acid cracking kettle is designed, the polyglycolic acid melt is stirred in the cracking kettle in the vertical direction and in the horizontal direction through the elliptic spiral stirring device in the cracking kettle when the polyglycolic acid is subjected to heating cracking so as to effectively disperse the polyglycolic acid, such that the carbonization caused by the polyglycolic acid accumulation is avoided, and the glycolide yield is improved.

Description

technical field [0001] The invention relates to the preparation of glycolide by adopting a cracking device, and belongs to the technical field of biomedical materials and synthesis techniques. Background technique [0002] Polyglycolic acid and its copolymers are an important class of biodegradable materials, which have broad and important uses in the field of biomedicine and many aspects of the national economy. The main chain of polyglycolic acid (PGA) and its copolymers is composed of easily hydrolyzed ester bonds, which are easily degraded by enzymes and moisture. The final products are carbon dioxide and water, which are non-toxic and non-irritating, and can participate in the tricarboxylic acid cycle. Polyglycolic acid has certain mechanical properties and processability, which can meet various application requirements, such as making medical devices. PGA is the first polymer used in absorbable biosuture materials. Homopolymers and copolymers of glycolic acid are cur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D319/12B01J19/20
CPCB01J19/20C07D319/12
Inventor 吴强姚如凤
Owner WATER CHEM CO LTD
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