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Detachable glass sand core dialysis device

A glass sand core and dialysis device technology, applied in dialysis, etc., can solve the problems of rising dialysis costs, swelling and cracking of dialysis bags, and increased volume of retained fluid, etc., and achieves the advantages of easy cleaning and sterilization, small environmental impact, and low cost of use Effect

Inactive Publication Date: 2015-08-19
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the traditional dialysis bag dialysis operation is inconvenient. At the same time, in order to make the impurity molecules in the sample solution seep out of the semi-permeable membrane as much as possible, it is necessary to continuously maintain the power of dialysis, that is, the diffusion pressure. formed by a concentration gradient
This requires frequent replacement of the dialysis solution, and the dialysis rate is slow, resulting in an increase in dialysis costs
On the other hand, during the dialysis process, because the dialysate molecules continue to enter the dialysis bag through the semi-permeable membrane, the volume of the retained fluid increases continuously, and the dialysis bag may even burst, resulting in the loss of the dialysis sample.

Method used

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  • Detachable glass sand core dialysis device
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  • Detachable glass sand core dialysis device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Divinylsulfone (DVS) cross-linked sodium hyaluronate gel was dialyzed using the dialysis device of the present invention to remove unreacted cross-linking agent. The upper and lower liquid storage tanks use G5 type glass sand cores, and the lower liquid storage tank is covered with a dialysis membrane with a molecular weight cut-off of 0.5KDa. Put the cross-linked sodium hyaluronate gel block that has been cross-linked into the dialysis tank, use the pre-configured phosphate buffer solution (PBS) as the dialysate, open the outlet knob of the lower liquid storage tank, and open the pressure reducing valve , Carry out dialysis under reduced pressure conditions (0.1MPa), take off the exudate flowing out from the liquid storage tank at regular intervals, and analyze the residual concentration of the cross-linking agent DVS in the exudate. In addition, the traditional dialysis bag method was used for dialysis comparison, and samples in the dialysis bag were taken ...

Embodiment 2

[0028] Example 2: Dialyzing the acid-treated collagen solution with pH=3.3 by using the dialysis equipment of the present invention to adjust the pH to neutral. The upper and lower liquid storage tanks use G2 type glass sand cores, and the lower liquid storage tank is covered with a dialysis membrane with a molecular weight cut-off of 0.2KDa. Put the cross-linked sodium hyaluronate gel block that has been cross-linked into the dialysis tank, dialyze with deionized water with a pre-configured pH=7.0, open the outlet knob of the lower liquid storage tank, and perform dialysis under normal pressure conditions , starting from dialysis with deionized water, remove the exudate from the storage tank at regular intervals, and analyze the pH value of the exudate. In addition, the traditional dialysis bag method was used for dialysis comparison. From the beginning of dialysis, samples in the dialysis bag were taken at regular intervals to analyze the pH value of the exudate. The test r...

Embodiment 3

[0031] Embodiment 3: adopt the dialysis equipment of the present invention, carry out dialysis to the polymethyl methacrylate that atom transfer radical polymerization (ATRP) method obtains, to remove Cu in the catalyst 2+ . The upper and lower liquid storage tanks use G3 type glass sand cores, and the lower liquid storage tank is covered with a dialysis membrane with a molecular weight cut-off of 0.1KDa. Put the polymerized polymethyl methacrylate into the dialysis tank, use the pre-prepared absolute ethanol as the dialysate, open the liquid outlet knob of the lower liquid storage tank, open the pressure reducing valve, and under the reduced pressure condition (0.1MPa ) for dialysis, remove the exudate from the storage tank at regular intervals, and analyze Cu in the exudate 2+ residual concentration. In addition, the traditional dialysis bag method was used for dialysis comparison, and samples in the dialysis bag were taken at regular intervals to analyze Cu 2+ residual c...

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Abstract

Disclosed is a detachable glass sand core dialysis device. The detachable glass sand core dialysis device specifically comprises five portions of a liquid preparation tank, an upper liquid storage tank, a lower liquid storage tank, a dialysis tank and a liquid collection tank; the top of the upper liquid storage tank is provided with the liquid preparation tank and a liquid inlet switch; the lower portion of the lower liquid storage tank is provide with a liquid outlet, a pressure reduction opening and the liquid collection tank; the liquid storage tanks are connected with the upper portion of the dialysis tank through a detachable connection opening and the liquid storage tanks are connected with the lower portion of the dialysis tank through a detachable connection opening for detachment and cleaning. According to the detachable glass sand core dialysis device, the structure is simple, the use cost is low, the detachment is easy, the cleaning sterilization is convenient, the environment influence in the process of dialysis is small, the use is safe and reliable, the detachable glass sand core dialysis device is suitable for the large-scale dialysis production of polymer solution, gel and other materials, the dialysis pressure can be regulated and controlled, and the smooth and rapid dynamic dialysis can be implemented.

Description

technical field [0001] The invention relates to a detachable glass sand core dialysis device, which is mainly used to speed up the dynamic dialysis of polymer solution or gel under negative pressure, and has important application value in the purification and separation of solution or gel. Background technique [0002] Traditional dialysis is a selective diffusion process that utilizes substances of different molecular weights to pass through a semipermeable membrane to separate impurity molecules with different molecular weights. Usually, the semi-permeable membrane is made into a bag, the sample solution is placed in the bag, and the dialysis bag is immersed in water or buffer solution, the molecules with large molecular weight in the sample solution are trapped in the bag, while the small molecular substances continue to diffuse Dialyze out of the bag until the concentrations on both sides of the bag reach equilibrium. The sample solution that remains in the dialysis bag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/28
Inventor 江国华李磊郑旭强
Owner ZHEJIANG SCI-TECH UNIV
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