2H,6H-pyrimido[2,1-b][1,3]thiazine derivative and application thereof
A technology of thiazides and derivatives, applied in the field of preparation of antibacterial drugs, can solve problems such as the crisis of effective clinical application of antibacterial drugs
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0018] Preparation of 4-{4-[2-(1-piperidinyl)ethoxy]phenyl}-5-acetyl-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
[0019] Add 0.1 mol of 4-[2-(1-piperidinyl)ethoxy]benzaldehyde, 0.1 mol of thiourea, 0.11 mol of 1-phenyl-1,3-butanedione into a 250 ml round bottom flask, Add 30 mL of acetic acid, stir, and react at 60°C for 10 h. Cool, filter with suction, and recrystallize the filter cake from absolute ethanol to obtain 30.4 g of yellow crystals, with a yield of 69.7%. ESI-MS (m / z): 436.2 (M+H) + .
Embodiment 2
[0021] Preparation of 4-{4-[2-(4-morpholinyl)ethoxy]phenyl}-5-acetyl-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
[0022] In a 250 ml round bottom flask, add 0.1 mol of 4-[2-(4-morpholinyl)ethoxy]benzaldehyde, 0.1 mol of thiourea, 0.11 mol of 1-phenyl-1,3-butanedione, Add 30 mL of acetic acid, stir, and reflux for 10 h. Cool, filter with suction, and recrystallize the filter cake from absolute ethanol to obtain 33.5 g of yellow crystals, with a yield of 76.7%. ESI-MS (m / z): 438.1 (M+H) + .
Embodiment 3
[0024] Preparation of 4-[4-(2-diethylaminoethoxy)phenyl]-5-acetyl-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
[0025] Add 0.1 mol of 4-(2-diethylaminoethoxy)benzaldehyde, 0.1 mol of thiourea, 0.11 mol of 1-phenyl-1,3-butanedione, and 30 mL of acetic acid into a 250 ml round bottom flask , stirred, and refluxed for 10 h. Cool, filter with suction, and recrystallize the filter cake from absolute ethanol to obtain 34.6 g of yellow crystals, with a yield of 81.8%. ESI-MS (m / z): 424.3 (M+H) + .
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com