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Correction method for determination of trace element in sample by isotope dilution mass spectrometry

A technology of isotope dilution and isotope, which is applied in the field of isotope dilution mass spectrometry, and can solve the problems of undiscovered instrument calibration method and so on.

Active Publication Date: 2015-09-09
BEIJING INST OF MEDICAL DEVICE TESTING
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no reported calibration method for instruments with reaction cell mode

Method used

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  • Correction method for determination of trace element in sample by isotope dilution mass spectrometry
  • Correction method for determination of trace element in sample by isotope dilution mass spectrometry
  • Correction method for determination of trace element in sample by isotope dilution mass spectrometry

Examples

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Effect test

Embodiment 1

[0023] Example 1 Determination of Selenium (Se) Content in Serum by Isotope Dilution Mass Spectrometry

[0024] 1. Instruments used

[0025] Inductively coupled plasma mass spectrometry (DRC-e type, PerkinElmer, USA)

[0026] Analytical balance (XS205DualRange, d=0.01mg, Mettler company, Germany)

[0027] Milli-Q A10 ultrapure water machine (Millipore, USA)

[0028] Milli-Q A10 ultrapure water machine (Millipore, USA)

[0029] Micro-control digital display heating plate (LabTech company)

[0030] MARS Microwave Digester; (USA)

[0031] VITLAB PTFE Beaker 50mL (Germany)

[0032] 2. Reagents used

[0033] Se standard substance SRM3149 (NIST)

[0034] Human Serum Standard Material SRM909c(NIST)

[0035] BV-III grade concentrated nitric acid (Beijing Institute of Chemical Reagents)

[0036] 98.8% isotope of 78Se (Oak Ridge Laboratory)

[0037] BV-III hydrogen peroxide 30% (Beijing Chemical Reagent Research Institute);

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Abstract

The present invention provides a correction method for determination of trace element in a sample by isotope dilution mass spectrometry, and belongs to the field of isotope dilution mass spectrometry determination. During value determination of the trace element in a to-be-tested sample by isotope dilution mass spectrometry, when isotopic abundance ratios of a to-be-tested element in a standard material solution and a to-be-tested sample solution are not equal due to matrix interference, the isotopic abundance ratio of the to-be-tested element in the standard material solution and the isotopic abundance ratio of the to-be-tested element in the to-be-tested sample solution are respectively measured, and then according to the correction method, correction coefficient K is calculated; and measurement value associated with the to-be-tested sample can be calibrated by use of the K value for finally realizing the accurate determination of the content of the trace element in the to-be-tested sample by isotope dilution mass spectrometry. The method solves the to-be-tested sample matrix interference effect on the value determination accuracy during determination of the content of the trace element in the to-be-tested sample by isotope dilution mass spectrometry.

Description

technical field [0001] The invention belongs to the field of isotope dilution mass spectrometry determination, in particular to a calibration method when isotope dilution mass spectrometry is used to measure trace elements in samples to be tested. Background technique [0002] In the process of mass spectrometry analysis, the detection of many elements will be affected by interference factors. The instrument itself also has a detection mode for eliminating interference. There are generally two modes for eliminating interference: reaction cell mode and collision cell mode. The principle of the reaction cell mode is: a reaction cell is equipped in the inductively coupled plasma mass spectrometer, and the reaction gas (methane, oxygen, ammonia) is introduced into the reaction cell, and the interference is eliminated through the chemical reaction between the reaction gas and the interference. For example: ArH pair 40 The interference of Ca can be eliminated by the reaction mode...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/626
Inventor 李胜民王军孙京昇刘毅杨忠向华
Owner BEIJING INST OF MEDICAL DEVICE TESTING
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