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A kind of triamcinolone acetonide-econazole nitrate patch

A technology of econazole nitrate patch and econazole nitrate, applied in the field of medicine, can solve problems such as the influence of pressure-sensitive adhesive adhesion, poor consistency of cream and the like

Active Publication Date: 2018-06-05
HENAN LINGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] For the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a kind of triamcinolone acetonide-econazole nitrate patch, which can effectively solve the problem of percutaneous penetration and lactation of triamcinolone acetonide-econazole nitrate in the prior art. The consistency of the paste is poor, and the effect of adding solvents on the adhesion of pressure-sensitive adhesives

Method used

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  • A kind of triamcinolone acetonide-econazole nitrate patch
  • A kind of triamcinolone acetonide-econazole nitrate patch

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Embodiment 1

[0016] When the present invention is implemented, it is made of a backing layer made of a backing material, a drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide, econazole nitrate, and a release layer made of a PET release film; The drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide and econazole nitrate consists of the following components by weight percentage: Duro-tak®2510 78.79%, 0.1% triamcinolone acetonide, 1% econazole nitrate, polyethylene glycol 400 10%, ethyl stearate 10%, benzoic acid 0.1% and butylated hydroxyanisole 0.01%.

Embodiment 2

[0018] When the present invention is implemented, it is made of a backing layer made of a backing material, a drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide, econazole nitrate, and a release layer made of a PET release film; The drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide and econazole nitrate consists of the following components by weight percentage: Duro-tak®2510 68.09%, triamcinolone acetonide 0.1%, econazole nitrate 1%, polyethylene glycol 400 15%, ethyl stearate 15%, benzoic acid 0.8% and butylated hydroxyanisole 0.01%.

Embodiment 3

[0020] When the present invention is implemented, it is made of a backing layer made of a backing material, a drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide, econazole nitrate, and a release layer made of a PET release film; The drug-loaded pressure-sensitive adhesive layer containing triamcinolone acetonide and econazole nitrate consists of the following components by weight percentage: Duro-tak®2510 57.39%, triamcinolone acetonide 0.1%, econazole nitrate 1%, polyethylene glycol 400 20%, ethyl stearate 20%, benzoic acid 1.5% and butylated hydroxyanisole 0.01%.

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Abstract

The present invention relates to triamcinolone acetonide-econazole nitrate patch, which can effectively solve the problem of poor consistency between percutaneous penetration of triamcinolone acetonide-econazole nitrate and cream, and the influence of adding solvent on the adhesion of pressure-sensitive adhesives in the prior art. The technical scheme that solves is, is made of the backing layer that backing material is made, the drug-loaded pressure-sensitive adhesive layer that contains triamcinolone acetonide, econazole nitrate and the release layer that PET release film is made; The percutaneous penetration of econazole nitrate of Azonide achieves the consistency of cream, and at the same time avoids the influence of solvent on the adhesion of pressure-sensitive adhesives. It is an innovation in the matrix-type long-acting skin drug delivery patch for the treatment of dermatitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a triamcinolone acetonide-econazole nitrate patch. Background technique [0002] Dermatitis eczema class dermatosis is common disease, frequently-occurring disease of dermatology. Clinically, any rash that has the characteristics of itching, erythema, papules, blisters, desquamation, hypertrophy, etc., and tends to exudate and merge, and it is difficult to make a definite diagnosis can be diagnosed as the disease first. Dermatitis and eczema are all recurrent, itchy skin diseases with complicated causes, and the pathogenesis is not yet fully clear. It is generally believed that it is a skin inflammatory reactive skin disease with obvious exudation tendency caused by the combined action of various internal and external factors. [0003] In recent years, a large number of studies on the etiology of eczema dermatitis-like skin diseases have found that the body's immune dysfunctio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K9/70A61K47/14A61P17/00A61P17/04A61K31/4174A61K47/10A61K47/12
Inventor 熊维政熊伟程剑军武惠斌汪晴李磊卢玉斌江开勇李晓辉丁雪
Owner HENAN LINGRUI PHARMA