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Coatings for Substrates

A technology of base material and base material surface, which is applied in the direction of coating, prosthesis, catheter, etc., and can solve problems such as difficulties in designing and manufacturing coatings

Active Publication Date: 2018-08-03
WL GORE & ASSOC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the in vivo release of particles / aggregates (known as granulation) from surface coatings can pose difficulties in the design and manufacture of coatings, in terms of health risks or debonding from the substrate to remove the coating is also potentially a problem

Method used

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  • Coatings for Substrates
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Examples

Experimental program
Comparison scheme
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Embodiment approach

[0209] In a first embodiment, the covalent linkage between the substrate surface and the hydrophilic coating is formed by the reaction of surface-bound radicals on the substrate surface with components of the hydrophilic coating, wherein the surface-bound The free radicals are formed by abstracting hydrogen atoms from the substrate surface.

[0210] Such as figure 1 As shown, in this embodiment, polymerization is initiated when the free radical initiator in the liquid phase contacts the surface to abstract hydrogen atoms from the substrate surface to form surface bound free radicals. Surface bound free radicals react with components A, B and C and D (when present and capable of such reactions – figure 1Only at least one reaction of components A and B) to covalently attach the copolymer to the surface is shown. Copolymers can pass through all of Components A, B and C and D (when present) (or at least through a copolymer that was previously present as Component A or Componen...

Embodiment 1

[0458] Example 1: Formation of a polymeric surface primer coating comprising extractable hydrogen atoms on a substrate

[0459] In the following examples, polydopamine surface primer coatings were formed on various substrates. When exposed to the polymerization solution, the QCM crystals and the PVC pipe substrate were horizontally aligned. All other substrates are aligned vertically. The polydopamine coating was subsequently analyzed for uniformity, adhesion and other properties and the results are given in Example 1a.

Embodiment 11

[0460] Example 1.1 Preparation of a Polydopamine Surface Primer Coating on a PEBAX Shaft at pH 8 and Using Pretreatment Method A

[0461] PEBAX axes were preconditioned according to Method A. Submerge the pretreated shaft in a deionized aqueous solution of tris buffer (1.21 g / L) and APS (0.6 g / L) and adjust the pH to 8.0 using HCl (1 M). Dopamine (1 g / L) was added to the solution and polymerization was allowed to proceed for 15, 30, 60 or 120 minutes. The polydopamine-primed shafts were rinsed with EtOH and dried at room temperature prior to analysis.

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Abstract

The present invention provides, but is not limited to, a substrate having a hydrophilic coating on its surface, the hydrophilic coating comprising components A and B, and optionally a crosslinked copolymer of components C and D; wherein component A Including one or more C2-C16 hydrophilic monomers, which respectively contain one or more alkenyl and / or alkynyl; Component B includes one or more hydrophilic polymers, which respectively contain two or more alkenyl and / or alkynyl groups; component C, when present, the component C includes one or more benefit agents, which respectively comprise one or more alkenyl or alkynyl groups; and component D , when present, the component D includes one or more low molecular weight crosslinking agents, which respectively contain two or more functional groups independently selected from mercapto, alkenyl and alkynyl; wherein the crosslinked Copolymers are formed by free radical polymerization involving alkenyl and / or alkynyl groups of components A, B and C (when present) and functional groups involving component D (when present); wherein the hydrophilic coating The layer optionally includes Component E comprising one or more benefit agents, wherein Component E does not form copolymers with Components A, B, C (when present) and D (when present) and wherein the hydrophilic coating is covalently attached to the substrate surface.

Description

field of invention [0001] The present invention relates to hydrophilic coatings for substrates such as medical devices, analytical equipment, separation equipment and other industrial articles including membranes and fabrics, and to methods for preparing such coatings. Background of the invention [0002] Medical devices such as catheters, guidewires, retractable sheaths, and stents often have surface coatings that serve to increase the physical properties of the device and extend its useful life. Of particular interest are hydrophilic coatings, which can also impart lubricity to the coated equipment. [0003] Lubricity describes the property of "slipperiness" or "slipperiness". Lubricious coatings are particularly useful for in vivo devices, where their lubricity results in reduced friction of the device once introduced and moved within the body, thereby enhancing patient comfort and reducing inflammation and tissue trauma. The composition of lubricious coatings can vary,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L29/08A61L31/10
CPCA61L27/34A61L27/54A61L29/085A61L29/16A61L31/10A61L31/16A61L2300/404A61L2300/41A61L2300/416A61L2300/418A61L2300/42A61L2400/10C08L33/08C08L71/02A61L29/08
Inventor P·安东尼D·尼斯特伦K·皮埃特扎克L·文森特
Owner WL GORE & ASSOC INC
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