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Coating for substrate

A technology of substrate and substrate surface, applied in coatings, catheters, prostheses, etc., can solve problems such as difficulties in designing and manufacturing coatings

Active Publication Date: 2015-09-23
WL GORE & ASSOC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the in vivo release of particles / aggregates (known as granulation) from surface coatings can pose difficulties in the design and manufacture of coatings, in terms of health risks or debonding from the substrate to remove the coating is also potentially a problem

Method used

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Examples

Experimental program
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Effect test

Embodiment approach

[0209] In a first embodiment, the covalent linkage between the substrate surface and the hydrophilic coating is formed by the reaction of surface-bound radicals on the substrate surface with components of the hydrophilic coating, wherein the surface-bound The free radicals are formed by abstracting hydrogen atoms from the substrate surface.

[0210] like figure 1 As shown, in this embodiment, polymerization is initiated when the free radical initiator in the liquid phase contacts the surface to abstract hydrogen atoms from the substrate surface to form surface bound free radicals. Surface bound free radicals react with components A, B and C and D (when present and capable of such reactions – figure 1Only at least one reaction of components A and B) to covalently attach the copolymer to the surface is shown. Copolymers can pass through all of Components A, B and C and D (when present) (or at least through a copolymer that was previously present as Component A or Component B...

Embodiment 1

[0458] Example 1: Formation of a polymeric surface primer coating comprising extractable hydrogen atoms on a substrate

[0459] In the following examples, polydopamine surface primer coatings were formed on various substrates. When exposed to the polymerization solution, the QCM crystals and the PVC pipe substrate were horizontally aligned. All other substrates are aligned vertically. The polydopamine coating was subsequently analyzed for uniformity, adhesion and other properties and the results are given in Example 1a.

Embodiment 11

[0460] Example 1.1 Preparation of a polydopamine surface primer coating on a PEBAX shaft at pH 8 and using Pretreatment method A

[0461] PEBAX axes were preconditioned according to Method A. Submerge the pretreated shaft in a deionized aqueous solution of tris buffer (1.21 g / L) and APS (0.6 g / L) and adjust the pH to 8.0 using HCl (1 M). Dopamine (1 g / L) was added to the solution and polymerization was allowed to proceed for 15, 30, 60 or 120 minutes. The polydopamine-primed shafts were rinsed with EtOH and dried at room temperature prior to analysis.

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Abstract

There is provided inter alia a substrate with a surface having a hydrophilic coating comprising a cross-linked copolymer of components A and B, and optional components C and D; wherein component A comprises one or more C2-C16 hydrophilic monomers each bearing one or more alkene and / or alkyne groups; component B comprises one or more hydrophilic polymers each bearing two or more alkene and / or alkyne groups; component C, if present, comprises one or more beneficial agents each bearing one or more alkene or alkyne groups; and component D, if present, comprises one or more low molecular weight cross-linking agents each bearing two or more functional groups independently selected from thiol, alkene and alkyne groups; wherein the cross-linked copolymer is formed by radical polymerisation involving the alkene and / or alkyne groups of components A, B and C (if present) and involving the functional groups of component D (if present); wherein the hydrophilic coating optionally comprises component E which comprises one or more beneficial agents, wherein component E does not form a copolymer with components A, B, C (if present) and D (if present); and wherein the hydrophilic coating is covalently attached to the surface of the substrate.

Description

field of invention [0001] The present invention relates to hydrophilic coatings for substrates such as medical devices, analytical equipment, separation equipment and other industrial articles including membranes and fabrics, and to methods for preparing such coatings. Background of the invention [0002] Medical devices such as catheters, guidewires, retractable sheaths, and stents often have surface coatings that serve to increase the physical properties of the device and extend its useful life. Of particular interest are hydrophilic coatings, which can also impart lubricity to the coated equipment. [0003] Lubricity describes the property of "slipperiness" or "slipperiness". Lubricious coatings are particularly useful for in vivo devices, where their lubricity results in reduced friction of the device once introduced and moved within the body, thereby enhancing patient comfort and reducing inflammation and tissue trauma. The composition of lubricious coatings can vary,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L29/08A61L31/10
CPCA61L31/16A61L31/10A61L29/16A61L2300/416A61L2300/41A61L2300/42A61L2400/10A61L2300/404A61L27/54A61L29/085A61L2300/418A61L27/34C08L33/08C08L71/02A61L29/08
Inventor P·安东尼D·尼斯特伦K·皮埃特扎克L·文森特
Owner WL GORE & ASSOC INC
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