Preparation method of liquidambar formosana leaf essential oil microcapsule and application of liquidambar formosana leaf essential oil microcapsule in relieving cough and reducing sputum

A technology of volatile oil and sweetgum leaves, applied in the field of medicine, can solve the problems of storage and use restrictions, strong volatility of volatile oil, easy to be oxidized, etc., and achieves the advantages of abundant raw materials, good water solubility and stability, and simple and easy preparation method. Effect

Inactive Publication Date: 2015-09-30
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the strong volatility of volatile oil, it is easy to be oxidized, resulting in great restrictions on its preservation and use.

Method used

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  • Preparation method of liquidambar formosana leaf essential oil microcapsule and application of liquidambar formosana leaf essential oil microcapsule in relieving cough and reducing sputum
  • Preparation method of liquidambar formosana leaf essential oil microcapsule and application of liquidambar formosana leaf essential oil microcapsule in relieving cough and reducing sputum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The mass ratio of 50g of 2:1 β- Dissolve dextrin and gum arabic in hot water at 60°C to obtain wall material solution A; dissolve 46g of the core material sweetgum leaf volatile oil and 4g of emulsifier soybean lecithin in hot water at 70°C to obtain solution B; Mix with B while it is hot, stir, and homogenize at 50°C and pressure 20MPa to obtain an emulsion; the homogenized emulsion enters the centrifugal dryer through the feeding pump, and the temperature of the inlet air is 160°C, and the outlet air Spray drying was carried out under the conditions of temperature 80°C and atomization pressure 0.5 MPa to obtain liquidambar volatile oil microcapsule particles with an embedding rate of 90.5%.

Embodiment 2

[0030] The mass ratio of 60g of 3:1 β- Dissolve dextrin and gum arabic in hot water at 70°C to obtain wall material solution A; dissolve 38g of the core material sweetgum leaf volatile oil and 2g of emulsifier soybean lecithin in hot water at 60°C to obtain solution B; Mix with B while it is hot, stir, and homogenize at 55°C and pressure 25MPa to obtain an emulsion; the homogenized emulsion enters the centrifugal dryer through a feeding pump, and the temperature of the inlet air is 200°C, and the outlet air Spray drying was carried out under the conditions of temperature 100°C and atomization pressure 0.4 MPa to obtain liquidambar volatile oil microcapsule particles with an embedding rate of 96.4%.

Embodiment 3

[0032] The mass ratio is 2.5:1 of 55g β- Dissolve dextrin and gum arabic in hot water at 65°C to obtain wall material solution A; dissolve 42g of the core material sweetgum leaf volatile oil and 3g of emulsifier soybean lecithin in hot water at 65°C to obtain solution B; Mix with B while it is hot, stir, and homogenize at 60°C and pressure 30MPa to obtain an emulsion; the homogenized emulsion enters the centrifugal dryer through the feeding pump, and the temperature of the inlet air is 180°C, and the outlet air Spray drying was carried out under the conditions of temperature 90°C and atomization pressure 0.2 MPa to obtain liquidambar volatile oil microcapsule particles with an embedding rate of 93.9%.

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Abstract

The invention discloses a preparation method of a liquidambar formosana leaf essential oil microcapsule and an application of the liquidambar formosana leaf essential oil microcapsule in relieving a cough and reducing sputum. The preparation method of the microcapsule is prepared by the following steps: dissolving wall materials beta-dextrin and arabic gum into hot water of 60-70 DEG C, and obtaining a wall material solution A; dissolving a core material liquidambar formosana leaf essential oil and an emulsifier soybean lecithin into hot water of 60-70 DEG C and obtaining a solution B; mixing the solution A with the solution B while hot, stirring and homogenizing to obtain an emulsion; and carrying out spray drying on the homogenized emulsion, and preparing the liquidambar formosana leaf essential oil microcapsule. The microcapsule is relatively good in water solubility and stability; and pharmacodynamics evaluation proves that the microcapsule has the effects of relieving the cough and reducing sputum, and can be used for preparing medicines for treating the cough and excessive phlegm.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of liquidambar volatile oil microcapsules and its application in relieving cough and eliminating phlegm. Background technique [0002] Liquidambar, also known as maple and triangular maple, is a representative plant of the genus Liquidambar in the family Hamamelis. Its leaves, bark, infructosis and resin all have medicinal value. It can ward off miasma and gangrene, dehumidify the name and name, and has the pharmacological effects of relaxing tendons and collaterals, promoting blood circulation and detoxification, relieving pain and promoting muscle growth. It is used for irregular menstruation, edema, swelling and fullness. , Difficulty urinating, low back pain, limb pain, skin mange, gastroenteritis, stubborn ringworm and other diseases. The leaves can be used for the treatment of oral diseases, and have the effects of hemostasis, pain relief...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/50A61K47/36A61P11/10A61P11/14
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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