Methods of treating cancer and preventing drug resistance

A cancer and resistance technology, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as unclear role of tumor cell subgroups, and achieve the effect of reducing side effects
CN104994879AInactive Publication Date: 2015-10-21F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2015-10-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are pharmaceutical products comprising therapeutically effective combinations of ALDH inhibitors (e.g., disulfiram and / or derivatives thereof) and targeted therapeutics, as well as methods of using said combinations for the treatment of cancer.
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Description

field of invention

[0001] Provided herein are therapies for the treatment of pathological conditions, such as cancer, using ALDH inhibitors and targeted therapeutics. Background of the invention

[0002] The relatively rapid acquisition of resistance to cancer drugs remains a key obstacle to successful cancer therapy. Significant efforts to elucidate the molecular basis of such drug resistance have revealed multiple mechanisms, including drug efflux, acquisition of drug-binding-deficient mutants of the target, involvement of alternative survival pathways, epigenetic alterations. Such mechanisms are generally thought to reflect the presence of rare, random, resistance-conferring genetic changes within tumor cell populations that are selected during drug treatment (Sharma et al., Cell 141(1):69-80 (2010)). A phenomenon that is increasingly observed in cancer therapy is the so-called "retreatment response". For example, some patients with non-small cell lung cancer (NSCLC) wh...

Claims

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