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Ginkgo ketonic ester dripping pill and preparation method thereof

A technology of ginkgo ketone ester and ester dripping pills, which is applied in the direction of medical raw materials derived from ginkgo biloba, pill delivery, and pharmaceutical formulations, which can solve the problems of long disintegration time, long time, and inability to solve the pain of patients, so as to relieve pain , fast disintegration effect

Active Publication Date: 2015-10-28
BEIJING HANDIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current medicines for the treatment of this disease mainly use ginkgo ketone ester as the main component, and drop pills are used to treat cardiovascular and cerebrovascular diseases; however, the disintegration time of the existing ginkgo ketone ester drop pills in the gastrointestinal tract is too long, generally 15 to 18 minutes , for the pain caused by the urgent need to solve the disease, it seems that it takes a long time for the patient to endure
[0004] The patent applications CN200610113450.7 and CN201010112227.7 proposed by the applicant reported ginkgo ketone ester drop pill preparations, but the drop pills made by it are not satisfactory in terms of dissolution rate, disintegration time limit, and appearance, and cannot solve the problem all the time. patient pain problem

Method used

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  • Ginkgo ketonic ester dripping pill and preparation method thereof
  • Ginkgo ketonic ester dripping pill and preparation method thereof
  • Ginkgo ketonic ester dripping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Take each component in the following proportions: 10g ginkgo ketone ester and 90g medicinal matrix, medicinal matrix is ​​by weight ratio 3:1.3 by Polyethylene Glycol 4000, Polyethylene Glycol 6000 and Polyethylene Glycol 8000: 0.4 composition;

[0034] (2) Ginkgo ketone ester passed through a 150-mesh sieve;

[0035] (3) Mix polyethylene glycol 4000, polyethylene glycol 6000 and polyethylene glycol 8000 in a stainless steel container, heat to 70°C, stir and keep warm for 3 minutes; The speed is 12 g / min, stir well, and continue to keep warm at 65°C;

[0036] (4) Dropping conditions: dropper diameter 3.5mm / 4.5mm, drop distance 6-8cm, adjust the drop valve (drop speed is about 50 drops per minute), drop the mixture of step (3) into the condensate of liquid paraffin at 16°C, Make 1000 dropping pills.

Embodiment 2

[0038] (1) Each component is taken in the following ratio: 18g ginkgo ketone ester and 82g medicinal matrix, medicinal matrix is ​​by weight ratio 5:1 by Polyethylene Glycol 4000, Polyethylene Glycol 6000 and Polyethylene Glycol 8000: 0.7 composition;

[0039] (2) Ginkgo ketone ester passed through a 100-mesh sieve;

[0040] (3) Mix polyethylene glycol 4000, polyethylene glycol 6000 and polyethylene glycol 8000 in a stainless steel container, heat to 85°C, stir and keep warm for 2 minutes; The speed is 15 g / min, stir well, and continue to keep warm at 60°C;

[0041] (4) Dropping conditions: dropper diameter 3.5mm / 4.5mm, drop distance 6-8cm, adjust the drop valve (drop speed is about 50 drops per minute), drop the mixture of step (3) into the condensate of methyl silicone oil at 13°C Into 1000 drop pills.

Embodiment 3

[0043] (1) Each component is taken in the following ratio: 15g ginkgo ketone ester and 85g medicinal matrix, medicinal matrix is ​​by weight ratio 4:1.3 by Polyethylene Glycol 4000, Polyethylene Glycol 6000 and Polyethylene Glycol 8000: 0.6 composition;

[0044] (2) Ginkgo ketone ester passed through a 130-mesh sieve;

[0045] (3) Mix polyethylene glycol 4000, polyethylene glycol 6000 and polyethylene glycol 8000 in a stainless steel container, heat to 78°C, stir and keep warm for 2 minutes; The speed is 13 g / min, stir well, and continue to keep warm at 62°C;

[0046] (4) Dropping conditions: dropper diameter 3.5mm / 4.5mm, drop distance 6-8cm, adjust the drop valve (drop speed is about 50 drops per minute), drop the mixture of step (3) into 17°C liquid paraffin and simethicone Mix the condensate into 1000 drop pills.

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Abstract

The invention discloses a ginkgo ketonic ester dripping pill, which comprises ginkgo ketonic ester and medicinal matrix, and the weight percentage of the two components is 10%-18%:82%-90%. The medicinal matrix comprises polyethylene glycol 4000, polyethylene glycol 6000 and polyethylene glycol 8000, and the weight ratio is 3-5:1-1.3:0.4-0.7. The invention also discloses a preparation method of the dripping pill. The product provided by the invention is composed of ginkgo ketonic ester and medicinal matrix according to a specific proportion, and the medicinal matrix is mixed from three kinds of polyethylene glycol, whose molecular weights are different, thereby ensuring fast disintegration speed of the ginkgo ketonic ester dripping pill, and the disintegration time is 6-10 minutes. The Ginkgo ketonic ester dripping pill can have a quick effect on human bodyand illness of a patient can be relieved.

Description

technical field [0001] The invention relates to a drop pill preparation and a preparation method thereof, in particular to a ginkgo ketone ester drop pill and a preparation method thereof. Background technique [0002] Dropping pills refer to the preparations made by solid or liquid medicine and matrix heated, melted and mixed, then dropped into immiscible condensate, shrinking and condensing; matrix generally includes water-soluble matrix and non-water-soluble matrix, commonly used are Polyethylene glycol 6000, gelatin, stearic acid, etc.; the condensate must be safe and harmless, and liquid paraffin, vegetable oil, methyl silicone oil, and water are commonly used. [0003] Cardiovascular and cerebrovascular diseases are characterized by high morbidity, high mortality and high disability, and are the number one killer of human health. The current medicines for the treatment of this disease mainly use ginkgo ketone ester as the main component, and drop pills are used to tre...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/34A61K36/16A61P9/00A61P9/10
Inventor 林德良
Owner BEIJING HANDIAN PHARMA CO LTD
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