Metformin hydrochloride and glibenclamide capsule and preparation method thereof

A technology of metformin glibenclamide and capsules, which is applied in the field of medicine, can solve the problems of high equipment requirements, and achieve the effects of good dissolution rate, simple process and stable release

Inactive Publication Date: 2015-11-11
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its preparation process requires a s...

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  • Metformin hydrochloride and glibenclamide capsule and preparation method thereof
  • Metformin hydrochloride and glibenclamide capsule and preparation method thereof
  • Metformin hydrochloride and glibenclamide capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0038] Metformin hydrochloride, glibenclamide, and fillers were pulverized and passed through an 80-mesh sieve. Weigh 2500 g of metformin hydrochloride, 12.5 g of glibenclamide, and 900 g of filler, and mix well. Take povidone 50g, add 450g dehydrated alcohol, make solution and make binder. The binder is added to the above mixture to prepare a soft material, which is granulated with a 20-mesh sieve. Dry using a fluidized granulation dryer. Use the 20-mesh sieve of the swing granulator to sieve the granules, add 3462.5g of granules and 10g of stearic acid into the mixer, and the mixing time is 10 minutes. Capsule filling with capsule filling machine.

[0039] See Table 1 for the types and amounts of fillers used in Examples 1-6 and related performance indicators.

[0040] As can be seen from the data in Table 1, Example 4 has the best performance.

[0041] The kind and consumption of the filler used in table 1 embodiment 1-6 and relevant performance index

[0042]

Embodiment 7-10

[0044] Metformin hydrochloride, glibenclamide, and pregelatinized starch were pulverized and passed through an 80-mesh sieve. Weigh 2500 g of metformin hydrochloride, 12.5 g of glibenclamide, and 900 g of pregelatinized starch, and mix them evenly. The binder is added to the above mixture to prepare a soft material, which is granulated with a 20-mesh sieve. Dry using a fluidized granulation dryer. Use the 20-mesh sieve of the swing granulator to sieve the granules, add 3462.5g of granules and 10g of stearic acid into the mixer, and the mixing time is 10 minutes. Capsule filling with capsule filling machine.

[0045] See Table 2 for the type and amount of binder used in Examples 7-10 and the properties of the prepared products.

[0046] As can be seen from the data in Table 2, Example 8 has the best performance.

[0047] The type and consumption of the adhesive used in table 2 embodiment 7-10 and the performance of the product prepared

[0048]

Embodiment 11-14

[0050] Metformin hydrochloride, glibenclamide, and pregelatinized starch were pulverized and passed through an 80-mesh sieve. Weigh 2500 g of metformin hydrochloride, 12.5 g of glibenclamide, and 900 g of pregelatinized starch, and mix them evenly. Take povidone 50g, add 450g dehydrated alcohol, make solution and make binder. The binder is added to the above mixture to prepare a soft material, which is granulated with a 20-mesh sieve. Dry using a fluidized granulation dryer. Use a 20-mesh sieve of a swing granulator to sieve the granules, add 3462.5 g of granules and a lubricant into the mixer, and the mixing time is 10 minutes. Capsule filling with capsule filling machine.

[0051] The types and amounts of lubricants used in Examples 11-14 and the properties of the prepared products are shown in Table 3.

[0052] As can be seen from the data in Table 3, Example 12 has the best performance.

[0053] The type and consumption of the adhesive used in table 3 embodiment 11-14...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a metformin hydrochloride and glibenclamide capsule and a preparation method thereof. The metformin hydrochloride and glibenclamide capsule is prepared from the following raw materials in parts by weight: 200-300 parts of metformin hydrochloride, 1.0-1.5 parts of glibenclamide, 44-135 parts of filler, 2.5-7.5 parts of adhesive and 0.5-1.5 parts of lubricant. The process provided by the invention is simple and easy to implement, and the prepared metformin hydrochloride and glibenclamide capsule has the advantages of steady release and high dissolution rate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a metformin glibenclamide capsule and a preparation method thereof. Background technique [0002] Diabetes is the second disease after cardiovascular disease. According to the WHO survey, there are hundreds of millions of diabetic patients in the world, 90% of whom are type Ⅱ diabetic patients. [0003] Because metformin can enhance tissue sensitivity to insulin and reduce glucose production, it has a certain synergistic effect with sulfonamide oral hypoglycemic drugs, and can also slow down the failure time of sulfonamide oral hypoglycemic drugs. Metformin can affect the complications of diabetes to a certain extent, improve fat metabolism, and also have a good effect on improving the weight of diabetic patients. Especially for obese type 2 diabetic patients, the use of metformin is more advocated in the early stage. [0004] Since the treatment of diabetes is a lo...

Claims

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Application Information

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IPC IPC(8): A61K31/64A61K9/48A61P3/10A61K31/155
Inventor 赵玉山黄京山李伟杨金成邵伟
Owner REYOUNG PHARMA
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