Equipment for rapidly and continuously manufacturing droplet microspheres and application thereof

Abstract

The invention relates to equipment for rapidly and continuously manufacturing droplet microspheres and application thereof. The equipment comprises a dispersed phase feeding device, a continuous phase feeding device, a continuous phase pressure tank and a rotating stirring device. The top of the continuous phase pressure tank is communicated with the continuous phase feeding device. The bottom of the continuous phase pressure tank is provided with an unloading opening. The side wall of the continuous phase pressure tank is provided with a discharging opening, a dispersed phase inlet hole and a ventilation hole from top to bottom. The dispersed phase feeding device is communicated with the dispersed phase inlet hole, and the rotating stirring device is arranged in the continuous phase pressure tank. According to the equipment for rapidly and continuously manufacturing droplet microspheres and the application, continuous phases and dispersed phases are conveyed into the continuous phase pressure tank continuously to achieve rapid and continuous material supply, and rotating blades play a role in assisting in material supply, so that working efficiency is improved; liquid drops are brought into a discharge device through inlet air in an air chamber, and the droplet microspheres are prepared efficiently, rapidly and continuously.

Description

Technical field [0001] The invention relates to a device for rapidly and continuously preparing droplet microspheres and its application, and belongs to the technical field of droplet microsphere preparation. Background technique [0002] Micro-droplets have many excellent properties such as small size, no diffusion between droplets, avoiding cross-contamination between droplets, stable reaction conditions, controllable mixing and many other excellent properties, and are more and more widely used. The droplet size uniformity (monodispersity) obtained by traditional mechanical stirring and colloid milling methods is poor; the microfluidic technology based on hydrodynamics is currently the main method for producing monodisperse microdroplets, but the rate is at ml / H level, although the micro-droplet growth rate can be improved by integrated micro-channels, it is still difficult to reach the order of l / h, and the mutual influence between multiple channels is large, which reduces th...

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Problems solved by technology

The droplet size uniformity (monodispersity) obtained by traditional mechanical stirring, colloid mill and other methods is poor; microfluidic technology based on hydrodynamics is currently the main method for manufacturing monodisperse microdroplets, but its rate is in the ml / h level, although the growth rate of micro-droplets can be increased by integrating micro-channels, it is still difficult to reach the level of 1 / h, and the interaction between multiple channels is relatively large, which reduces the controllability and production continuity of the system. The output that cannot meet the needs of industrial production

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