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Calcium supplementing preparation/granule and preparation method thereof

A technology for preparation and calcium supplementation, applied in pharmaceutical formulations, medical preparations containing active ingredients, peptide/protein ingredients, etc., can solve the problems of loss, poor absorption of ordinary calcium agents, poor solubility and absorption rate, etc. The effect of bone density

Inactive Publication Date: 2015-11-18
BEIJING RICKEN NUTRITIONAL SCI RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its solubility and absorption rate are poor, requiring a large amount of gastric acid to be decomposed into calcium ions to be absorbed
[0015] The second generation is the stage of calcium supplementation and supplementation of functional factors to promote calcium absorption. Calcium is mainly inorganic calcium, and functional factors are mainly vitamin D. At the same time, it also pays attention to the balance between minerals, such as calcium-phosphorus ratio, calcium-magnesium ratio and Calcium and iron balance, etc., but utilization is still limited
[0016] Although there are so many calcium products available, almost all of them remain in the stage of "calcium supplementation". Ordinary calcium preparations are poorly absorbed and the loss is serious. 90% of people are in a state of calcium starvation throughout their lives, and the incidence of osteoporosis is high.

Method used

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  • Calcium supplementing preparation/granule and preparation method thereof
  • Calcium supplementing preparation/granule and preparation method thereof
  • Calcium supplementing preparation/granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] This embodiment provides a calcium supplement preparation, including the following raw materials in parts by mass:

[0068] 20 parts of bone collagen, 6 parts of milk mineral salt, 0.8 part of casein phosphopeptide, 0.4 part of colostrum basic protein,

[0069] Vitamin D 3 0.0000067 parts, 4 parts of sweet orange powder, 26 parts of maltodextrin, 21 parts of skimmed milk powder.

[0070] The above-mentioned calcium supplement preparations can also be in the form of granules, and the production process is as follows: figure 1 shown, including the following steps:

[0071] 1. Weighing:

[0072] In an environment with a temperature of 18°C ​​and a relative humidity of 50%, weigh 20 parts of bone collagen, 6 parts of milk mineral salt, 0.8 part of casein phosphopeptide, 0.4 part of colostrum basic protein, and 0.0000067 part of vitamin D 3 , 26 parts of maltodextrin, 21 parts of skimmed milk powder, 4 parts of sweet orange powder.

[0073] 2. Total mix:

[0074] ①Mix ...

Embodiment 2

[0094] The difference between this embodiment and Example 1 is that it includes the following raw materials in parts by mass:

[0095] 30 parts of bone collagen, 10 parts of milk mineral salt, 1.2 parts of casein phosphopeptide, 0.6 part of colostrum basic protein,

[0096] Vitamin D 3 0.00001 parts, 6 parts of sweet orange powder, 40 parts of maltodextrin, 33 parts of skimmed milk powder.

[0097] The above-mentioned calcium supplement preparation can also be in the form of granules, and its production process includes the following steps:

[0098] 1. Weighing:

[0099] In an environment with a temperature of 26° C. and a relative humidity of 20%, the above raw materials were weighed in parts by mass.

[0100] 2. Total mix:

[0101] ①Mix vitamin D3 and 1 / 10 maltodextrin in equal increments, and record it as mixture A; mix casein phosphopeptide, colostrum basic protein, and sweet orange powder evenly, and record it as mixture B;

[0102] Note: Equal incremental mixing met...

Embodiment 3

[0125] The difference between this embodiment and Example 1 is that it includes the following raw materials in parts by mass:

[0126] 25 parts of bone collagen, 8 parts of milk mineral salt, 1.0 part of casein phosphopeptide, 0.5 part of colostrum basic protein,

[0127] Vitamin D 3 0.000007 parts, 5 parts of sweet orange powder, 30 parts of maltodextrin, 30 parts of skimmed milk powder.

[0128] The above-mentioned calcium supplement preparation can also adopt granules, and its production process includes the following steps:

[0129] 1. Weighing:

[0130] In an environment with a temperature of 20° C. and a relative humidity of 45%, the above-mentioned raw materials in parts by mass were weighed respectively.

[0131] 2. Total mix:

[0132] ①Mix vitamin D3 and 1 / 10 maltodextrin in equal increments, and record it as mixture A; mix casein phosphopeptide, colostrum basic protein, and sweet orange powder evenly, and record it as mixture B;

[0133] Note: Equal incremental ...

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Abstract

The invention provides a calcium supplementing preparation. The calcium supplementing preparation comprises the following raw materials in parts by weight: 20-30 parts of bone collagen, 6-10 parts of milk minerals, 0.8-1.2 parts of casein phosphopeptides, 0.4-0.6 part of colostrum basic protein, 0.0000067-0.00001 part of vitamin D3, 26-40 parts of maltodextrin, 21-33 parts of skimmed milk powder and 4-6 parts of sweet orange powder. A preparation method of the calcium supplementing preparation is simple in preparation process and has good effects. The calcium supplementing preparation is used for scientifically supplementing calcium aiming at each stage at which skeletons require comprehensive nutrients. A scheme of supplementing, absorbing, conveying, locking and surviving is adopted to enable the skeletons to actively absorb calcium, promote absorption of calcium, also implant calcium on the skeletons to lock calcium, stimulate osteoblast, suppress the activity of osteoclast, promote skeleton rebuilding and surviving calcium.

Description

technical field [0001] The invention relates to a calcium supplement preparation, a granule and a manufacturing method thereof. Background technique [0002] In China, people's main food is cereals, and the calcium content in cereals is very low. The survey shows that calcium deficiency is very common and serious in Chinese people. The per capita daily calcium deficiency is as high as 250mg~350mg. The average prevalence rate of rickets in children under 3 years old is 40.7%. There are 200 million women suffering from bone hyperplasia and calcium deficiency in pregnant women. The number of people is 100% of the monitored objects. Secondly, as people grow older, calcium in the human body is constantly being lost. Experts estimate that people are in the period of calcium balance between the ages of 20 and 35, the period of calcium growth before the age of 20, and the period of calcium loss after the age of 35. The rate of calcium loss is accelerating year by year, and the ave...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/14A61P19/10A61P19/08A61K31/593
Inventor 刘爱民
Owner BEIJING RICKEN NUTRITIONAL SCI RES CO LTD
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