Method for extracting and separating betulinic acid from cornus officinalis kernels

A technology of dogwood kernels and betulinic acid is applied in the directions of steroids, organic chemistry, etc., to achieve the effect of good separation effect and simple separation process

Inactive Publication Date: 2015-11-18
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these studies focus on the pulp of Cornus officinalis, but there are few reports on the specific chemical components related to the activity in the fruit stone.

Method used

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  • Method for extracting and separating betulinic acid from cornus officinalis kernels
  • Method for extracting and separating betulinic acid from cornus officinalis kernels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 1. Obtain the dichloromethane layer extract (Mc layer) with good solubility and good development effect

[0013] Remove the pulp from the fruit of Cornus officinalis and take the core, wash it with distilled water, dry it in the shade, put it into a pulverizer and crush it into powder, use a sieve to remove the very fine powder, put the remaining sample into a jar, add absolute ethanol to make it The sample is completely submerged. Ultrasonic extraction was performed for 20 minutes at 800W power and 30°C, and was repeated three times. The extracts were combined, filtered under reduced pressure, and the solvent was removed from the filtrate by a rotary evaporator to obtain crude ethanol extract. The solvent was removed from the filtrate by a rotary evaporator, and the temperature was controlled below 50° C. to obtain an ethanol extract. Stir and oscillate the ethanol extract with distilled water, add an equal volume of n-hexane after fully dissolving, stir for 4 hours ...

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Abstract

The invention discloses a method for extracting and separating betulinic acid from cornus officinalis kernels, and belongs to the technical field of extraction technology of betulinic acid. According to the method, an extraction method of natural products is adopted, mechanical disruption and pulverizing, sieving, digestion, filtration, vacuum concentration, extraction, and slica column chromatography and other separation technologies are carried out, the betulinic acid with various biological activities is separated from the cornus officinalis kernels, the separation technology is simple and relatively good in separating effect, and the mass percent content of the betulinic acid reaches 0.39%.

Description

technical field [0001] The invention belongs to the technical field of extraction technology of betulinic acid, and in particular relates to a method for extracting and separating betulinic acid from dogwood fruit stones. Background technique [0002] In recent years, natural products and their derivatives have shown great prospects in the application of health care products, food additives and drug development, especially the development and utilization of active ingredients in some medicinal and food homologous materials. dogwood, scientific name Cornus officinalis Sieb.etZucc. is a tree species in the north temperate zone and north subtropical zone. It is mainly distributed in East Asian countries, such as China, Japan, and North Korea. The areas where the distribution is relatively concentrated in my country are Funiu Mountain in Henan, Tianmu Mountain in Zhejiang, and Hanzhong in Shaanxi. Cornus officinalis has been used as medicine in my country since ancient times. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
CPCC07J63/008
Inventor 许明录王兰许光日李勇超孟志芬胡林峰李淑梅冯喜兰胡建和
Owner HENAN INST OF SCI & TECH
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