Absorbable medical suture with good compatibility and preparation method thereof

A suture and compatibility technology, applied in the field of medical sutures, can solve the problems of slow degradation rate, supply, easy cell adhesion, etc., and achieve the effect of increasing smoothness, reducing pain, and reducing tissue drag.

Active Publication Date: 2018-10-12
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] PGA fiber is very suitable for cell adhesion and reproduction, but due to its fast degradation rate, it cannot provide sufficient strength before tissue formation; compared with PGA fiber, the degradation rate of PLA fiber is slower, but PLA is hydrophobic, Cells cannot adhere and reproduce well on fibers. When using sutures made of this type of polymer, it is difficult to meet the two conditions of slow degradation rate and easy cell adhesion and reproduction.

Method used

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  • Absorbable medical suture with good compatibility and preparation method thereof

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preparation example Construction

[0031] refer to figure 1 , the preparation method of a kind of good compatibility absorbable medical suture that the present invention proposes, comprises the steps:

[0032] S1. Preparation of suture fiber: mix polyglycolide, modified polylactic acid, polylactic acid, hyaluronic acid, methyl methacrylate, epoxy soybean oil, and tea tree oil, heat up to 60-80°C, and heat up to 60-80°C. Stir at a speed of -300r / min for 4-6 hours, heat up to 100-120°C, extrude with a twin-screw extruder, water-cool, air-dry, and pelletize to obtain masterbatches; heat up to 150-170°C to melt the masterbatch and defoam , obtain primary fibers through a spinneret; stretch the primary fibers in a water bath at 40-60°C to obtain suture fibers;

[0033] S2. Prepare a coating solution: add polycaprolactone into ethanol and stir, then add calcium stearate powder and stir, and heat up to 40-50°C to obtain a coating solution;

[0034] S3. Coating weaving: Coating the suture fibers obtained in S1 with t...

Embodiment 1

[0037] A kind of absorbable medical suture with good compatibility, its raw material comprises by weight: 40 parts of polyglycolide, 10 parts of modified polylactic acid, 70 parts of polylactic acid, 10 parts of hyaluronic acid, 7 parts of methyl methacrylate 4 parts, 4 parts of epoxy soybean oil, 4 parts of tea tree oil, 1 part of polycaprolactone, 0.3 part of calcium stearate, 15 parts of ethanol;

[0038]Wherein, the preparation method of the modified polylactic acid is as follows: add 2 parts of polylactic acid in 20 parts of chloroform to dissolve in parts by weight, feed nitrogen, add 6 parts of 2-ethylhexyl methacrylic anhydride, heat up to 70 ° C, Insulate for 2 hours, cool, add dropwise to 150 parts of ethanol, filter with suction, heat up to 40°C, and dry in vacuum for 15 hours to obtain the intermediate material; add 7 parts of itaconic acid to 40 parts of oxalyl chloride in parts by weight, heat up to 90°C, and keep warm 3h, suction filtration, soak the filter cake...

Embodiment 2

[0044] A kind of absorbable medical suture with good compatibility, its raw material comprises by weight: 20 parts of polyglycolide, 20 parts of modified polylactic acid, 50 parts of polylactic acid, 20 parts of hyaluronic acid, 5 parts of methyl methacrylate 6 parts, 6 parts of epoxy soybean oil, 2 parts of tea tree oil, 5 parts of polycaprolactone, 0.1 part of calcium stearate, 30 parts of ethanol;

[0045] Wherein, the preparation method of the modified polylactic acid is as follows: add 4 parts of polylactic acid to 10 parts of chloroform to dissolve in parts by weight, feed nitrogen, add 13 parts of 2-ethylhexyl methacrylic anhydride, heat up to 50 ° C, Insulate for 4 hours, cool, add dropwise to 100 parts of ethanol, filter with suction, heat up to 60°C, and vacuum-dry for 10 hours to obtain the intermediate material; add 11 parts of itaconic acid to 30 parts of oxalyl chloride in parts by weight, heat up to 110°C, and keep warm 2h, suction filtration, soak the filter ca...

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Abstract

The invention discloses a good-compatibility and absorbable medical suture line which comprises, by weight, 20-40 parts of polyglycollide, 10-20 parts of modified polylactic acid, 50-70 parts of polylactic acid, 10-20 parts of hyaluronic acid, 5-7 parts of methyl methacrylate, 4-6 parts of epoxidized soybean oil, 2-4 parts of tea tree oil, 1-5 parts of polycaprolactone and 0.1-0.3 part of calcium stearate. The invention further discloses a production method of the good-compatibility and absorbable medical suture line. The method includes the steps of S1, producing suture line fibers; S2, preparing coating solution; S3, braiding coating. The medical suture line has the advantages that the suture line is good in compatibility with biological tissues, good in mechanical performance, resistant to degradation and simple to operate, adhesion and reproduction of cells on the suture line are facilitated, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable medical suture with good compatibility and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Synthetic polymer sutures include polyglycolide (PGA) sutures, polylactic acid (PLA) sutures, polydioxanone (PDS) sutures, and the like. Absorbable sutures can be degraded and absorbed in the body, which avoids the pain caused by the second surgery, and can choose sutures with different degradation times according to actual surgical needs. [0004] PGA fiber is very suitable for cell adhesion and reproduction, but due to its fast d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/12A61L17/10A61L17/14D06M15/507D06M13/188D01F8/14D01F1/10D06M101/32
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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