Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of method for preparing high-content nemoctine

A technology of weight and protecting group, applied in the field of preparing high-content nimoctin, can solve problems such as low content of nimoctin products

Active Publication Date: 2017-07-07
INNER MONGOLIA JIARUIMI FINE CHEM CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problem of low content of nemoctine products existing in the prior art, the present invention provides a method for preparing high-content nemoctine, which has the advantages of simple post-treatment, few times of column separation and high content of nemoctine Advanced merit

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of method for preparing high-content nemoctine
  • A kind of method for preparing high-content nemoctine
  • A kind of method for preparing high-content nemoctine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The technical process of present embodiment preparation high-content nemoctine is as follows:

[0034]

[0035] (1) Reduction reaction:

[0036] Add 4.0g of 5-oxo(4-nitrobenzoyl)-23-oxonimoxetine (5.0mmol, 1.0eq, HPLC purity 95.0A%, white powder) into a 100mL three-necked flask, add 40.0g of methanol and stir After uniformity, a milky white suspension was obtained, put it into an ice-water bath and cool to 0~5°C, add 567mg (15.0mmol, 3.0eq) of sodium borohydride in batches, keep stirring for 1.0h after the addition, and pour the reaction solution into 40.0g of water , extracted twice with 40.0 g of dichloroethane, and the obtained oil layer was evaporated under negative pressure to remove the solvent to obtain 4.0 g (4.9 mmol, HPLC purity 94.0A%).

[0037] (2) Deprotection reaction:

[0038] 4.0g (4.9mmol, 1.0eq) of 5-oxo(4-nitrobenzoyl)-nimoctine obtained in step (1) was mixed with dichloroethane (20.0g) and methanol (20.0g) After dissolving, transfer it to a 10...

Embodiment 2

[0042]The technical process of present embodiment preparation high-content nemoctine is as follows:

[0043]

[0044] (1) Reduction reaction:

[0045] Add 8.1g of 5-oxo(4-chlorophenoxyacetyl)-23-oxonimoxetine (10.0mmol, 1.0eq, HPLC purity 96.2A%, white powder) into a 250mL three-necked flask, add methanol 81.0g Stir evenly to obtain a milky white suspension, put it in an ice-water bath to cool to 0~5°C, add 1135mg (30.0mmol, 3.0eq) of sodium borohydride in batches, keep stirring for 1.0h after the addition, and pour the reaction solution into 80.0g In water, extracted twice with 80.0 g of dichloroethane, and the obtained oil layer was vacuum-rotated to remove the solvent to obtain light yellow 5-oxo(4-chlorophenoxyacetyl)-nimoctine 8.0 g (9.8 mmol, HPLC purity 96.0A%).

[0046] (2) Deprotection reaction:

[0047] 8.0g (9.8mmol, 1.0eq) of the above-mentioned 5-oxo(4-chlorophenoxyacetyl)-Nimoctine was dissolved in 40.0g dichloroethane and 40.0g methanol, then transferred t...

Embodiment 3

[0051] The technical process of present embodiment preparation high-content nemoctine is as follows:

[0052]

[0053] (1) Deoxime reaction:

[0054] Add 4.0g (4.9mmol, 1.0eq, HPLC purity 97.02A%, white powder) of 5-oxo(4-nitrobenzoyl)-23-methoximoxine to a 100mL three-necked flask, add dioxane 40.0g dissolved clear, then added 3.6g hydrochloric acid (9.9g, 97.6mmol, 20.0eq, content 36wt.%), then heated to 50°C and kept stirring for 10.0h. The reaction solution was poured into 40.0g of water, extracted twice with 40.0g of dichloroethane, and the obtained oil layer was rotated to dryness under negative pressure to obtain light yellow 5-oxo(protecting group)-23-oxonimoxetin 3.8g (4.8mmol, HPLC purity 96.5A%, yield 98.0%).

[0055] (2) The reduction reaction, deprotection reaction and silica gel column separation process were the same as in Example 1, and finally 2.8 g of nimoctine (HPLC purity 96.5A%, content 93.7 wt.%, white solid) was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing high-content nemoctine, which belongs to the technical field of organic chemistry. The method uses 5-oxygen (protecting group)-23-oxonimoxetine or 5-oxygen (protecting group)-23-methoxinimoctine after crystallization and purification as raw materials, and undergoes deoximation, reduction, and removal. Protection and silica gel column separation to obtain high-content nemoctine, the HPLC purity of the obtained nemoctine is ≥95.0A%, and the content is ≥93.0wt.%. The method should have the advantages of simple post-treatment, less times of column separation and high content of nemoctine.

Description

technical field [0001] The invention relates to the technical field of preparation of nemoctine in organic chemistry, in particular to a method for preparing high-content nemoctine. Background technique [0002] Nemadectin is a sixteen-membered macrolide antibiotic produced by fermentation of Streptomyces blue gray (J.Chem.Soc., Chem.Commun., 1987, (6), 402-404) , is an antiparasitic drug. Nimoctine is further chemically modified by introducing a methyloxime group (=N-OCH 3 ) can obtain a more active insecticide, Moxidectin, which is currently widely used in veterinary clinics. It is a broad-spectrum, high-efficiency, new type of macrolide anthelmintic antibiotic. [0003] During the fermentation process, Streptomyces couscous produces not only nemoctine, but also various structural analogues, which are not easy to remove. At present, the main method to prepare high-content nemoctine is to separate and purify through multiple column separations of different types of macro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22
CPCY02P20/55
Inventor 戴耀李贺先刘玲玲赵宇航王荣良
Owner INNER MONGOLIA JIARUIMI FINE CHEM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com