Crosslinked peptide hydrogels
A hydrogel, amphiphilic peptide technology, applied in the field of hydrogel, can solve the problems of low rigidity, unsuitable physiological characteristics and/or complexity, high production cost, etc.
Inactive Publication Date: 2015-11-25
AGENCY FOR SCI TECH & RES
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Problems solved by technology
[0006] However, currently known peptide hydrogels are associated in most cases with low stiffness, sometimes with unfavorab
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[0305] Experiments have been performed to illustrate the technical aspects of the exemplary embodiments of the present invention. The following examples are described in the Experimental Methods and Results section. The skilled artisan will readily recognize that the examples are intended to be illustrative and not intended to limit the scope of the invention.
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Abstract
The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using the hydrogel in accordance with the present invention.
Description
technical field [0001] The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and / or peptoids capable of self-assembling into a three-dimensional macromolecular nanofibrous network that entraps water and forms the hydrogel A gel, wherein at least a portion of said plurality of amphiphilic peptides and / or peptoids is chemically cross-linked. The present invention further relates to methods of preparing such hydrogels and various uses of such hydrogels, for example as a cell culture substrate, for drug delivery and gene delivery, as a wound dressing, as an implant use as an injectable that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices the use of. It also relates to methods of tissue regeneration or tissue replacement using the hydrogels according to the invention. Background technique [0002] Supramolecular structures are held tog...
Claims
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Login to view more IPC IPC(8): C07K7/06C07K5/103A61K38/07A61K38/06A61K8/64A61P19/00A61L27/52
CPCA61K8/042A61K8/64A61K38/00A61K2800/5428A61K2800/91A61K2800/95A61L15/425A61L15/60A61L27/227A61L27/52A61L27/56A61L31/047A61L31/145A61L31/146A61L2300/402A61L2300/404A61L2300/406A61L2300/41A61L2300/414A61L2300/42A61L2300/426A61L2300/438A61L2400/06A61L2400/12A61Q19/00A61Q19/08C07K5/06043C07K5/0808C07K5/101C07K7/06C07K7/08C12M25/14A61P19/00C08L89/00
Inventor 夏洛特·豪泽尔邵威阳
Owner AGENCY FOR SCI TECH & RES
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