Grisic quinone A, grisic quinone B, and preparation method and medical application of grisic quinone A and grisic quinone B

A technology of gray mold quinone and gray mold, applied in the field of medicine, can solve the problems that the clinical curative effect does not reach the expected effect, drug resistance affects the curative effect, etc., and achieve the effect of inducing brain glioma cell apoptosis and good application prospects

Inactive Publication Date: 2015-12-02
ZHEJIANG UNIV
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Problems solved by technology

Although molecularly targeted drugs have opened up a new way for cancer treatment, their clinical efficacy has not achieved the desired effect, and the increasing resistance of cancer cells to anticancer drugs has also seriously affected the efficacy of existing drugs

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  • Grisic quinone A, grisic quinone B, and preparation method and medical application of grisic quinone A and grisic quinone B
  • Grisic quinone A, grisic quinone B, and preparation method and medical application of grisic quinone A and grisic quinone B
  • Grisic quinone A, grisic quinone B, and preparation method and medical application of grisic quinone A and grisic quinone B

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Embodiment Construction

[0043] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, but the present invention is not limited to these embodiments.

[0044] Streptomyces griseus Streptomyces griseus Isolation and culture of P82SMLY

[0045] Take 3 grams of air-dried marine sediment and dilute it to a concentration of 0.01 g / mL with a liquid culture medium. The composition of each 100 mL of the liquid culture medium is: 1.5 grams of glucose, 1.5 grams of glycerol, 1.5 grams of malt extract, 2.5 grams of yeast extract, 0.5 grams of casamino acids and 0.1 grams of calcium carbonate. Take 200 The sample dilution solution was evenly dispersed into a petri dish containing solid culture medium of Bacto-agar, and after culturing at room temperature for 10 days, different colonies were transferred to another culture dish containing solid culture medium of Bacto-agar. Cultured dishes were cultured for 7 days at room temperatu...

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Abstract

The invention provides grisic quinone A, grisic quinone B, and a preparation method and medical application of the grisic quinone A and the grisic quinone B. Streptomyces griseus P82SMLY separated from marine sediment is provided, and the preservation number is CCTCC NO: M 2015386. Two marine natural products with antiglioma activity, such as the grisic quinone A and the grisic quinone B, are obtained by extracting and classifying a bacterial strain, and the grisic quinone A and the grisic quinone B are new compounds. The grisic quinone A and the grisic quinone B have a feature of obviously inhibiting multiplication of various kinds of glioma cells, can induce apoptosis of the glioma cells obviously, and accordingly can be used for preparing medicines for treating glioma. The chemical structural formula of the grisic quinone A and the grisic quinone B is as shown in the specification.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to new marine natural products streptoanthraquinone A (streptoanthraquinone A) and streptoanthraquinone B (streptoanthraquinone B) with biological activity, a preparation method thereof, and an application in preparing antitumor drugs. Background technique [0002] Malignant tumor (cancer) is a serious hazard to human health and life. It is the disease with the highest mortality rate in the world today, and it is also the first cause of death for urban and rural residents in my country. Chemotherapy is currently the main method of drug treatment after tumor surgical resection in the world, but chemotherapy has high toxicity and limited curative effect. Although molecularly targeted drugs have opened up a new way for the treatment of cancer, their clinical efficacy has not achieved the desired effect, and the increasing resistance of cancer cells to antitumor drugs has also seriously affected t...

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P17/06C07D309/14C07D311/78A61K31/351A61K31/352A61P35/00C12R1/545
Inventor 张治针梁英陈璐连晓媛
Owner ZHEJIANG UNIV
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