Unlock instant, AI-driven research and patent intelligence for your innovation.

Drug delivery stent or support with novolimus and lactide based coating such that novolimus has a minimal amount of bonding to the coating

A lactide and coating technology, applied in the field of polymer coatings for medical devices, can solve the problems of high therapeutic value, no value, and expensive

Active Publication Date: 2018-01-19
ABBOTT CARDIOVASCULAR
View PDF27 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This outcome can be extremely costly and of little value as any therapeutic value of drug degradation products and drug-polymer adducts is hardly as high as that of the unaltered drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug delivery stent or support with novolimus and lactide based coating such that novolimus has a minimal amount of bonding to the coating
  • Drug delivery stent or support with novolimus and lactide based coating such that novolimus has a minimal amount of bonding to the coating
  • Drug delivery stent or support with novolimus and lactide based coating such that novolimus has a minimal amount of bonding to the coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0142] Implantable devices comprising macrocyclic drug-PLA polymer conjugates were fabricated and tested as described in the Prophetic Examples below.

[0143] implantable device

[0144] Stents composed of bioresorbable polymers are manufactured by manipulating the polymer into tubes at temperatures above the polymer's melting point, after which the stent model is machined with a laser. The bracket model itself is a multi-link made of a series of corrugated rings connected by links.

[0145] polymer

[0146] PLA-based polymers such as pure poly(L-lactide), poly(L-lactide-co-D, L-lactide) or poly(L-lactide-co-caprolactone ) for brackets. When D,L-lactide or caprolactone is present, the preferred amount is from 1% (w / w) to 10% (w / w). Poly(L-lactide) polymers having an intrinsic viscosity of 2.0 dL / gm to 5.0 dL / gm may also be used. Coronary stents were fabricated with strut thicknesses and strut widths ranging from 100 microns to 175 microns.

[0147] coating

[0148]A co...

Embodiment approach 1

[0156] Embodiment 1. A bioabsorbable stent comprising a stent body and a coating on the stent body comprising a poly(D,L-lactide) polymer and novolimus conjugated to the polymer, wherein The amount of novolimus conjugated to the polymer is less than or equal to 0.35% (weight of novolimus / weight of polymer) as measured by liquid chromatography-mass spectrometry (LC-MS).

Embodiment approach 2

[0157] Embodiment 2. The bioabsorbable scaffold of embodiment 1, wherein the amount of novolimus conjugated to the polymer is less than or equal to 0.30% (weight of novolimus) as measured by liquid chromatography-mass spectrometry (LC-MS). / polymer weight).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
number average molecular weightaaaaaaaaaa
glass transition temperatureaaaaaaaaaa
glass transition temperatureaaaaaaaaaa
Login to View More

Abstract

Drug delivery medical devices are disclosed herein. A polymer coating for a medical device is provided that contains a minimal amount of drug bound to the polymer in the coating.

Description

technical field [0001] Drug delivery medical devices are disclosed herein. More specifically, polymer coatings for medical devices are provided that contain minimal amounts of drug bound to the polymer in the coating. Background technique [0002] Most drug delivery stents and scaffolds consist of three components: (1) stent / stent structure, substrate or body, (2) polymer coating and (3) usually present to reduce new Therapeutic agents for intimal hyperplasia and restenosis. The main purpose of the polymer coating is to immobilize the drug on the stent and control its release rate. A bioresorbable stent comprises a bioresorbable stent structure and a bioresorbable coating. Bioresorbable coatings were also placed on metal supports to provide benefits compared to permanent polymer coatings. [0003] As a drug / device combination, drug delivery stents must meet existing standards for drug release rate control and maintenance of drug purity. An example of such a standard is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/16A61K47/59
CPCA61L31/148A61L2300/416A61K47/593A61K47/6957A61L31/10A61L31/16A61L2420/02A61P7/00A61P9/00A61P9/10C08L67/04A61K31/436
Inventor 丁尼史蒂芬·帕塞蒂玛丽卡·坎贝里卡梅伦·克里根
Owner ABBOTT CARDIOVASCULAR