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Efficient and antibacterial oxygen humidification fluid and method for preparing same
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An oxygen humidifying liquid, high-efficiency technology, applied in the fields of botanical equipment and methods, chemicals for biological control, animal repellents, etc. The effect of low cost, good clinical value and simple preparation process
Active Publication Date: 2015-12-16
浙江康德药业集团股份有限公司
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A large number of domestic literatures report that the humidification fluid is easily contaminated by bacteria during the oxygen inhalation process, thus causing nosocomial infections
Method used
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Embodiment 1
[0017] Embodiment 1: Preparation of oxygen humidification liquid
[0018] Prescription: sodium dehydroacetate 0.02g, natamycin 0.1g, add purified water to 1000ml.
[0019] Preparation process: Take 900ml of purified water, add sodium dehydroacetate, heat to dissolve, then add natamycin, stir to dissolve, add purified water to the full amount, sterilize at 115°C for 30 minutes, cool, and fill , sealed, and stored for later use after passing the test.
Embodiment 2
[0020] Embodiment 2: Preparation of oxygen humidification liquid
[0021] Prescription: sodium dehydroacetate 0.05g, natamycin 0.03g, add purified water to 1000ml.
[0022] Preparation process: Take purified water, add sodium dehydroacetate, heat to dissolve, then add natamycin, stir to dissolve, add purified water to the full amount, sterilize at 115°C for 30 minutes, cool, fill, Sealed, and stored for later use after passing the test.
Embodiment 3
[0023] Embodiment 3: Bacteriostasis test of humidification liquid
[0024] Using 38 strains of Staphylococcus aureus, 36 strains of Escherichia coli, 32 strains of Pseudomonas aeruginosa, 8 strains of Morganella, 15 strains of Citrobacter freundii, 8 strains of Klebsiella pneumoniae, and slime sand 8 strains of Ratella sp., 17 strains of Bacillus subtilis, a total of 162 strains of 8 species were quantitatively inoculated in the nutrient broth and the nutrient broth containing 0.05‰ sodium dehydroacetate + 0.03‰ natamycin, and placed in a temperature of 35 ° C. box for a 48-hour incubation. The results are presented: the nutrient broth control group is obviously turbid, and the bacteria grow well, while the nutrient broth containing the compound borax solution is clear and transparent, showing that the bacterial reproduction is inhibited.
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Abstract
The invention provides efficient and antibacterial oxygen humidification fluid and a method for preparing the same. The efficient and antibacterial oxygen humidification fluid comprises sodium dehydroacetate and natamycin. The method includes steps of adding the sodium dehydroacetate into purified water; heating the sodium dehydroacetate and the purified water to dissolve the sodium dehydroacetate; adding the natamycin into the purified water and stirring the natamycin to dissolve the natamycin; supplementing the balance purified water to obtain the efficient and antibacterial oxygen humidification fluid; heating and sterilizing the efficient and antibacterial oxygen humidification fluid; filling and sealing the efficient and antibacterial oxygen humidification fluid; inspecting the efficient and antibacterial oxygen humidification fluid and storing the efficient and antibacterial oxygen humidification fluid for standby application after the efficient and antibacterial oxygen humidification fluid is qualified. The efficient and antibacterial oxygen humidification fluid and the method have the advantages that the sodium dehydroacetate and the natamycin are added into humidification fluid, synergistic antibacterial effects can be realized by the sodium dehydroacetate and the natamycin which are active constituents, and accordingly the humidification fluid can be effectively guaranteed against being contaminated by bacteria in clinical service procedures.
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