Nano-phospholipid liposome cosmetic containing lava seawater and preparation method thereof
A lava seawater and phospholipid technology, applied in the chemical industry, can solve the problems of sensitive skin prone to irritation, difficulty in maintaining long-term product stability, and poor skin affinity of cosmetics
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Embodiment 1
[0066] Embodiment 1, the preparation of the nano-phospholipid liposome composition containing lava seawater
[0067] Prepare the following ingredients:
[0068] Hydrogenated lecithin: LESINOL S-10, purchased from NIKKO CHEMICAL;
[0069] Ceramide: DS CERAMIDE, purchased from DUSAN BIOTEC;
[0070] Cyclomethicone: KF 995, purchased from SHINETSU;
[0071] Lava seawater: Jeju lava seawater, purchased from BIOLAND;
[0072] Glycerin: GLYCERINE, available from EMERY OLEO.
[0073] Utilize above-mentioned raw material, prepare the nano-phospholipid liposome composition containing lava seawater, its specific formula is shown in Table 1.
[0074] Table 1
[0075]
[0076] According to the formula shown in Table 1, the nano-phospholipid liposomes used for cosmetics are formulated, and its preparation method is as follows:
[0077] Put the water phase into the adjustable and stirred vacuum emulsification pot and heat to 75°C, and then put the oil phase into the oil phase disso...
Embodiment 2
[0078] Embodiment 2, the identification of the nano-phospholipid liposome composition containing lava seawater
[0079] The distribution and size of the particles in each composition prepared in the foregoing Example 1 were tested by a particle size analyzer (NANOPHOX, Germany). A schematic diagram of the analytical instrument used is shown in figure 2 a.
[0080] Such as figure 1 As shown, in Composition 1, nano-sized phospholipid liposomes were well formed, with an average particle size of 10-40 nm. Similarly, nano-sized phospholipid liposomes were well formed in Composition 2, with an average particle size of 10 to 40 nm.
[0081] On the contrary, when the phospholipid content in composition 3 is lower than 0.5% or the phospholipid content in composition 4 is higher than 8.0%, the liposome formation effect is not good, and stable nanoparticles cannot be formed.
[0082] In composition 5, the oil component emulsifier exceeds 20%, forming too much internal phase, and the...
Embodiment 3
[0084] Embodiment 3, osmotic absorption test
[0085] The permeability of composition 1 and general emulsion was tested respectively, and the release amount of the sample over time was tested by ERWEKA DT800 dissolution apparatus. In the test, an artificial skin membrane was used to simulate the penetration effect of the sample on human skin. Depend on figure 2 B It can be seen that the release amount of composition 1 is significantly higher than that of ordinary emulsion.
[0086] General Lotion Formulation:
[0087]
[0088] The result is as figure 2 B, by figure 2 B shows that phospholipid liposomes are particles of 10-40nm, which are smaller than skin lipids, so they are easier to penetrate the skin and can maximize the effect of physiologically active substances.
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