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A kind of pharmaceutical composition for preventing and treating animal influenza virus infection and preparation method thereof

A technology of influenza virus infection and composition, applied in the field of medicine, can solve the problems of low toxicity of traditional Chinese medicine preparations, rapid variation of influenza virus subtypes, and easy epidemics, etc., to inhibit animal influenza virus infection, reduce heavy metal ion content, reduce Toxic effects

Active Publication Date: 2019-10-25
山东省动物疫病预防与控制中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Influenza virus is the main pathogen that causes acute viral respiratory infectious diseases. It has the characteristics of high infectivity, rapid transmission, and easy occurrence of epidemics. The subtype of influenza virus mutates quickly, while the research and production of vaccines are slow, making chemical drugs It is difficult for vaccines and influenza virus vaccines to exert their best therapeutic and preventive effects, and it is currently impossible to effectively predict the time and cycle of influenza outbreaks
Traditional Chinese medicine has comprehensive effects such as inhibiting virus replication, preventing virus-induced cell lesions, and regulating immune function, and the toxicity of traditional Chinese medicine preparations is low, and it is not easy to produce drug resistance. Therefore, Chinese medicine has unique advantages and broad development prospects in the prevention and treatment of animal influenza virus infection. However, the existing traditional Chinese medicine preparations have problems such as excessive heavy metal content and narrow prevention and treatment range.

Method used

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  • A kind of pharmaceutical composition for preventing and treating animal influenza virus infection and preparation method thereof
  • A kind of pharmaceutical composition for preventing and treating animal influenza virus infection and preparation method thereof
  • A kind of pharmaceutical composition for preventing and treating animal influenza virus infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pharmaceutical composition for preventing and treating influenza virus infection in animals. The raw materials are composed of: 8 parts of Magnolia officinalis bark, 1.5 parts of Liaogewang, 9 parts of licorice, 8 parts of honeysuckle, 1 part of allicin, and 0.1 part of phytate , 3 parts of monoglyceride citric acid.

[0023] The preparation method is as follows:

[0024] (1) Add magnolia bark, Liaogewang, licorice, honeysuckle and monoglyceride citrate to 70vol% ethanol which accounts for 8 times the total weight of raw materials, then add medical stones, soak at 30°C for 25 minutes, Take out the medical stone;

[0025] The fast adding amount of the medical stone is Magnolia officinalis bark, 5 times of the total weight of Licorice, Radix Glycyrrhizae and Flos Lonicerae;

[0026] (2) Reflux extraction for 40 minutes, filter, add ethanol which accounts for 8 times its weight to the filter residue, reflux extraction for 2 hours, filter, combine the two filtrates, con...

Embodiment 2

[0028] A pharmaceutical composition for preventing and treating influenza virus infection in animals. The raw materials are as follows: 5 parts of Magnolia officinalis bark, 3 parts of Liaogewang, 8 parts of licorice, 6.5 parts of honeysuckle, 1.5 parts of allicin, and 0.2 parts of phytate , 2 parts of monoglyceride citric acid.

[0029] The preparation method is as follows:

[0030] (1) Add magnolia bark, Liaogewang, licorice, honeysuckle and monoglyceride citrate to 75% ethanol which accounts for 8 times the total weight of raw materials, then add medical stones, soak at 30°C for 25 minutes, Take out the medical stone;

[0031] The fast adding amount of the medical stone is Magnolia officinalis bark, 5 times of the total weight of Licorice, Radix Glycyrrhizae and Flos Lonicerae;

[0032] (2) Reflux extraction for 50 minutes, filter, add ethanol which accounts for 8 times its weight to the filter residue, reflux extraction for 1 hour, filter, combine the two filtrates, conc...

Embodiment 3

[0034] A pharmaceutical composition for preventing and treating influenza virus infection in animals. The raw materials are: 6.4 parts of Magnolia officinalis bark, 1 part of Liaogewang, 9 parts of licorice, 5 parts of honeysuckle, 1.2 parts of allicin, and 0.15 parts of phytate , 4 parts of monoglyceride citric acid.

[0035] The preparation method is as follows:

[0036] (1) Add magnolia bark, Liaogewang, licorice, honeysuckle and monoglyceride citrate to 75% ethanol which accounts for 8 times the total weight of raw materials, then add medical stones, soak at 30°C for 25 minutes, Take out the medical stone;

[0037] The added amount of the medical stone block is Magnolia officinalis bark, 5 times of the total weight of Licorice, Radix Glycyrrhizae and Flos Lonicerae Flos Lonicerae;

[0038] (2) Reflux extraction for 45 minutes, filter, add ethanol which accounts for 8 times its weight to the filter residue, reflux extraction for 1.5 hours, filter, combine the two filtrate...

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating animal influenza virus infection and a preparation method of the pharmaceutical composition, and belongs to the technical field of medicines. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 5-8 parts of magnoliae officinalis bark, 1-3 parts of wikstroemia indica, 8-10 parts of licorice root, 5-8 parts of lonicera japonica flower, 1-1.5 parts of allicin, 0.1-0.2 part of inositol hexaphosphate and 2-4 parts of citric acid monoglyceride. The pharmaceutical composition can be used for effectively inhibiting animal influenza virus infection, has small toxic or side effects, can be orally taken in daily application, and has good palatability and quick drug effect performance. According to the preparation method, the content of heavy metal ions can be effectively reduced by adding medical stones; and by combination of different extraction methods and solvent, the effective ingredients in medicinal materials can be extracted to the greatest extent, and toxic or side effects can be reduced.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine composition for preventing and treating animal influenza virus infection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Influenza virus is the main pathogen that causes acute viral respiratory infectious diseases. It has the characteristics of high infectivity, rapid transmission, and easy occurrence of epidemics. The subtype of influenza virus mutates quickly, while the research and production of vaccines are slow, making chemical drugs It is difficult for influenza and influenza virus vaccines to exert their optimal therapeutic and preventive effects, and it is currently impossible to effectively predict the time and cycle of influenza outbreaks. Traditional Chinese medicine has comprehensive effects such as inhibiting virus replication, preventing virus-induced cell lesions, and regulating immune function, and the toxicity ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/105A61K36/83A61K47/24A61K47/14A61K47/02A61P31/16A61K31/255
Inventor 王贵升于青海田野田夫林陈静马泽芳
Owner 山东省动物疫病预防与控制中心
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