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Application of 8-hydroxyquinoline-7-salicylhydrazide acetal compound to cadmium ion fluorescent probe

A technology of aldehyde salicylic hydrazide and hydroxyquinoline, which is applied in the field of optical analysis and detection, can solve the problems of difficult absorption of cadmium, lack of iron or calcium, etc., and achieves the effects of good permeability and fast fluorescence response

Inactive Publication Date: 2015-12-23
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Cadmium is more difficult to absorb, but cadmium intake can lead to iron or calcium deficiency

Method used

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  • Application of 8-hydroxyquinoline-7-salicylhydrazide acetal compound to cadmium ion fluorescent probe
  • Application of 8-hydroxyquinoline-7-salicylhydrazide acetal compound to cadmium ion fluorescent probe
  • Application of 8-hydroxyquinoline-7-salicylhydrazide acetal compound to cadmium ion fluorescent probe

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Experimental program
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Effect test

Embodiment 1

[0026] Optimization of Experimental Conditions

[0027] 1. Selection of probe molecule concentration

[0028] Increasing the concentration of probe molecules can increase the absorbance and fluorescence intensity, which is beneficial to improve the selectivity of the determination of metal ions and the linear range of the standard curve. However, when the concentration is too high, the fluorescence intensity of the blank will also increase with the increase of the probe molecule concentration, and if the concentration is too low, it will be difficult to detect the fluorescence absorption peak after adding ions. Considering the sensitivity and linear range of the method, the probe The concentration is chosen to be 1.0×10 -3 mol / L.

[0029] 2. Selection of buffer solution

[0030] Add 1mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer solution to a 10mL colorimetric tube, and then add 0.01mL of the molar concentration to 1.0×10 -3 mol / L DMF-H of 8-hydroxyquinoline-7-a...

Embodiment 2

[0037]Add 1mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer solution to multiple 10mL colorimetric tubes, and then add 0.01mL of the molar concentration to 1.0×10 -3 mol / L DMF-H of 8-hydroxyquinoline-7-aldehyde salicylhydrazide 2 O (DMF and H 2 The volume ratio of O is 1:99) solution, and then add different concentrations of cadmium ion solutions respectively, use deionized water to make the volume to 10mL, shake and mix for 20min, then measure the fluorescence intensity of each solution, the fluorescence intensity measurement condition is excitation narrow Slit 5nm, emission slit 10nm, excitation wavelength 369nm, emission wavelength 470nm, the fluorescence absorption peak at 470nm in the fluorescence absorption spectrum gradually increases with the increase of cadmium ion concentration, determine the quantitative relationship between fluorescence intensity and cadmium ion concentration and make a standard curve (Such as image 3 ), where the limit of detection (LOD...

Embodiment 3

[0041] Add 1mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer solution to multiple 10mL colorimetric tubes, and then add 0.01mL of the molar concentration to 1.0×10 -3 mol / L DMF-H of 8-hydroxyquinoline-7-aldehyde salicylhydrazide 2 O solution, and then add the molar concentration of 1.0×10 -3 mol / L metal ion standard solution, dilute to 10mL with deionized water, shake well and measure the fluorescence intensity of each solution (such as Figure 4 ), the results show that when various metal ions of the same concentration interact with the probe molecule KXZ, only Cd 2+ and Zn 2+ The addition of the mixed system increases the fluorescence intensity at 470nm, while other metal ions interact with the probe molecule, compared with the blank sample, the fluorescence intensity does not change significantly, indicating that the probe molecule KXZ has the ability to recognize cadmium ions and zinc ions. Very good choice.

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Abstract

The invention discloses an application of 8-hydroxyquinoline-7-salicylhydrazide acetal compound to a cadmium ion fluorescent probe, belonging to the technical field of optical analysis and detection. A chemical formula of the 8-hydroxyquinoline-7-salicylhydrazide acetal compound is shown in the specification. The invention also discloses a specific application process of the 8-hydroxyquinoline-7-salicylhydrazide acetal compound as the cadmium ion fluorescent probe. The 8-hydroxyquinoline-7-salicylhydrazide acetal compound has good permeability in cells as the fluorescent probe, is quick in fluorescent response to cadmium ions and can be better used for chemical sensors for detection of the cadmium ions in the cells.

Description

technical field [0001] The invention belongs to the technical field of optical analysis and detection, and specifically relates to the application of 8-hydroxyquinoline-7-aldehyde salicylic hydrazide compound in cadmium ion fluorescent probes. Background technique [0002] Metals mostly exist in the form of ions in organisms, and a variety of metal ions can promote or hinder life activities in organisms. Therefore, how to detect metal ions in the environment and in organisms is of great significance to environmental science, medicine and people's health. Among the various existing detection methods, fluorescent ion chemical sensors provide a better way for the detection of metal ions due to their advantages of simple operation, high sensitivity and low price. [0003] Zinc ions are the second most abundant transition metal ions in the natural environment, Zn 2+ It is considered to be an ion that plays an important role in the construction of cells and the regulation of phy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06G01N21/64C07D215/26
Inventor 时蕾潘峰刘统信麻娜娜张贵生刘青峰
Owner HENAN NORMAL UNIV
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