Valsartan/azelnidipine oral preparation and preparation method thereof

Abstract

The invention discloses a valsartan / azelnidipine oral preparation and a preparation method thereof. The oral preparation is characterized by comprising a main medicine and auxiliary materials, wherein the main medicine comprises valsartan and azelnidipine; the auxiliary materials include a filling agent, a disintegrating agent, an adhesive and a lubricating agent and glidant. The oral preparation is prepared through the processing steps of raw material selection, preparation, mixing, soft material preparation, granulation, drying, granule straightening, total mixing, finished product preparation, and the like. The valsartan / azelnidipine oral preparation composition for treating hypertension has the beneficial effects that valsartan is an orally effective angiotensin II(AT1) receptor antagonist with specificity; azelnidipine belongs to a dihydropyridine calcium channel antagonist; the product is a compound preparation of two kinds of anti-hypertension branded medicines, is suitable for the patients whose blood pressures can not be controlled by using a single medicine, has good curative effects, is convenient to use and has the effect of greatly improving the medicine use compliance of the patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a valsartan / azendipine oral preparation and a preparation method thereof. Background technique [0002] The treatment of hypertension requires long-term effective antihypertensive therapy and combined antihypertensive therapy to stabilize blood pressure and significantly reduce the morbidity and mortality of cardiovascular and cerebrovascular diseases. The reasons why combined medication is needed are as follows: 1. The control rate of single antihypertensive drugs is low. Hypertension is a multifactorial disease with complex pathogenesis. Therefore, no matter how effective the antihypertensive drug is, it often only works on a certain pathogenesis, and it is difficult to control other related pathogenesis. A single drug cannot effectively control blood pressure for a long time, and the fluctuation increases. 2. When a single drug cannot meet the standard, many people often ...

AI Technical Summary

Problems solved by technology

Therefore, no matter how effective antihypertensive drugs are, they often only work on a certain pathogenesis, and it is difficult to control other related pathogenesis. A single drug cannot effectively control blood pressure for a long time, and the fluctuation increases.

2. When a single drug cannot meet the standard, many people often consider increasing the drug dose, and at the same time the side effects of the drug increase accordingly. Sometimes patients cannot tolerate it, so they stop the drug at will, resulting in blood pressure fluctuations, which instead increases the incidence of cardiovascular and cerebrovascular diseases rate and its dangers

Clinical studies have shown that the antihypertensive effect of the dual drug regimen is reliable and stable, but it cannot meet the market demand