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Pharmaceutical composition for restraining cerebral thrombosis

A technology of cerebral thrombosis and composition, which is applied in the field of pharmaceutical composition for inhibiting cerebral thrombosis, and achieves the effect of definite curative effect and low toxicity and side effects

Inactive Publication Date: 2016-01-06
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this medicinal material is used to treat diseases such as dental malnutrition, infantile malnutrition, rheumatic arthralgia, and diarrhea. There is no literature report that Siscifolia or its extracts have the effect of inhibiting cerebral thrombosis

Method used

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  • Pharmaceutical composition for restraining cerebral thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 is to the preparation of sitting leaf water extract

[0016] Put 800 g of the dry product of sitting leaves into a round-bottomed flask, and successively use 8 L of 95% (v / v) ethanol and 8 L of 75% (v / v) ethanol to extract twice, each time for 4 hours, pour out the ethanol extract, Add 10L of water to the obtained dregs, decoct twice for 2 hours each time, combine the two water extracts, filter, concentrate into a thick paste, dry under reduced pressure at 70°C, pulverize into fine powder, and pass through a 100-mesh sieve to obtain the opposite leaf water extract.

Embodiment 2

[0017] Embodiment 2 is to the preparation of sitting leaf water extract

[0018] Put 1 kg of the dry product of sitting leaves into a round bottom flask, and successively use 10 L of 90% (v / v) ethanol and 10 L of 70% (v / v) ethanol to extract twice, each time for 4 hours, and pour out the ethanol extract. Add 12L of water to the obtained dregs, decoct twice for 2 hours each time, combine the two water extracts, filter, concentrate into a thick paste, dry under reduced pressure at 70°C, pulverize into fine powder, pass through a 100-mesh sieve, and obtain the opposite leaf water extract.

Embodiment 3

[0021] Example 3 Study on the Inhibition of Cerebral Thrombosis Mice by the Extract of Siscifolia

[0022] 36 healthy SD rats, half male and half female, body weight 200-220g, rats were randomly and evenly divided into the following three groups according to body weight and sex: ① model control group, intragastric administration of normal saline 1ml / 100g body weight; ② alcohol extraction Object group, gavage of 42 mg / kg of the ethanol extract of citrate leaf prepared by the process of comparative example; 3. water extract group, gavage of 42 mg / kg of citrate leaf water extract prepared by the process of embodiment 1 of the present invention. Rats in each group were given the corresponding test substance once a day for 8 consecutive days.

[0023] One hour after the last administration, the cerebral thrombosis model was prepared as follows: rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 30 mg / kg. Separate the trachea and perform tracheal intubat...

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Abstract

The invention discloses a pharmaceutical composition for restraining cerebral thrombosis. The pharmaceutical composition is prepared from a hedyotis uncinella aqueous extract and pharmaceutically available auxiliary materials; the hedyotis uncinella aqueous extract is prepared through the following steps: placing a hedyotis uncinella raw material in an extraction container; carrying out reflux extraction with ethanol, the concentration of which is gradient concentration; removing an alcohol extracting solution; adding water into herb residues for decocting; filtering the decoction to obtain an aqueous extract solution; concentrating the aqueous extract solution into thick paste; drying the thick paste; and smashing the dried thick paste so as to obtain the hedyotis uncinella aqueous extract. The pharmaceutical composition disclosed by the invention is prepared from the single Chinese herbal medicine, has a definite curative effect on the aspect on prevention of cerebral thrombosis, is low in toxic and side effects and belongs to environment-friendly treatment medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a pharmaceutical composition for inhibiting cerebral thrombosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the most serious diseases threatening human beings in the world today, and its morbidity and mortality have surpassed tumors and ranked first in the world. Among them, cerebrovascular disease refers to a group of diseases with cerebral hemorrhagic or ischemic injury symptoms as the main clinical manifestation caused by cerebral blood vessel rupture, bleeding or thrombosis, also known as cerebrovascular accident or stroke, commonly known as cerebral apoplexy , is currently one of the three leading cause of death. Clinical epidemiological data show that the incidence of stroke in my country is 1.5 million per year, and the death rate is 1 million per year. According to foreign statistics, ischemic cerebrovascular d...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P7/02A61P9/10A61P7/10
Inventor 王宝林姜玉萍
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO