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Method for preparing antibacterial and anticancer titanium dioxide nanotubes using ruthenium complexes

A technology of ruthenium complexes and titanium dioxide, which is applied in the field of preparing titanium dioxide nanotubes with antibacterial and anticancer properties, to achieve excellent antitumor effects, easy to obtain raw materials, and good antibacterial effects

Active Publication Date: 2018-06-22
嘉兴慧泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of ruthenium complexes with antibacterial effects to improve the antibacterial effect of titanium dioxide nanotubes, and ruthenium complexes can endow titanium dioxide nanotubes with antibacterial and anticancer effects, especially the ability to resist bone cancer

Method used

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  • Method for preparing antibacterial and anticancer titanium dioxide nanotubes using ruthenium complexes
  • Method for preparing antibacterial and anticancer titanium dioxide nanotubes using ruthenium complexes
  • Method for preparing antibacterial and anticancer titanium dioxide nanotubes using ruthenium complexes

Examples

Experimental program
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Effect test

Embodiment 1

[0027] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0028] 1) 66 parts by weight of ruthenium trichloride hydrate and 475 parts by weight of gamma-terpinene were dissolved in 1455 parts by weight of dehydrated alcohol, heated to reflux and stirred for 6 hours, and left to separate out to obtain a compound of formula (1), That is, dichloro-di-methylisopropylbenzene diruthenium(II) dichloride;

[0029]

[0030] 2) Weigh 27 parts by weight of thiosemicarbazide and 28 parts by weight of p-thiazolylbenzaldehyde and dissolve them in 870 parts by weight of absolute ethanol, heat to 70 ° C, and after 4 hours, stand to separate out to obtain formula (2) The compound, namely p-thiazolyl formaldehyde thiosemicarbazone;

[0031]

[0032] 3) 5 parts by weight of p-thiazolyl formaldehyde thiosemicarbazone and 6 parts by weight of dichloro-bis-methylisopropylbenzene diruthenium (II) are dissolved in 1...

Embodiment 2

[0039] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0040] 1) 65 parts by weight of ruthenium trichloride hydrate and 470 parts by weight of 95% gamma-terpinene with a ruthenium content of 37% were dissolved in 1450 parts by weight of dehydrated alcohol, heated under reflux and stirred for 6 hours, and statically Set out to obtain the compound with formula (1), i.e. dichloro-dichloro-bis-methylisopropylbenzene diruthenium (II);

[0041]

[0042] 2) Weigh 27 parts by weight of thiosemicarbazide and 25 parts by weight of p-thiazolylbenzaldehyde and dissolve them in 870 parts by weight of absolute ethanol, heat to 70 ° C, and after 4 hours, stand to separate out to obtain formula (2) The compound, namely p-thiazolyl formaldehyde thiosemicarbazone;

[0043]

[0044] 3) 4.5 parts by weight of p-thiazolyl formaldehyde thiosemicarbazone and 4 parts by weight of dichloro-bis-methylcumene diruth...

Embodiment 3

[0051] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0052] 1) 70 parts by weight of 37% ruthenium trichloride hydrate and 480 parts by weight of gamma-terpinene with a purity of 95% were dissolved in 1500 parts by weight of dehydrated alcohol, heated and stirred under reflux for 6 hours, and statically Set out to obtain the compound with formula (1), i.e. dichloro-dichloro-bis-methylisopropylbenzene diruthenium (II);

[0053]

[0054] 2) Weigh 35 parts by weight of thiosemicarbazide and 28 parts by weight of p-thiazolylbenzaldehyde and dissolve them in 910 parts by weight of absolute ethanol, heat to 70 ° C, and after 4 hours, stand to separate out to obtain formula (2) The compound, namely p-thiazolyl formaldehyde thiosemicarbazone;

[0055]

[0056]3) 5.5 parts by weight of p-thiazolyl formaldehyde thiosemicarbazone and 6 parts by weight of dichloro-bis-methylcumene diruthenium (II) a...

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Abstract

The invention discloses a method for preparing titanium dioxide nanotubes with antibacterial and anticancer functions through ruthenium complex. The method includes the following steps that 1, ruthenium complex is obtained; 2, the ruthenium complex is dissolved in water; 3, the titanium dioxide nanotubes are soaked in an ethyl alcohol solution, nitrogen gas is introduced, and microwave processing is conducted; 3, the mixture stands still and cooled to the room temperature, pressure is raised to 20-25 Mpa, the pressure is lowered to normal pressure after being maintained for 2-3 minutes, and centrifugation is conducted for 30-60 minutes; 4, liquid supernatant obtained after centrifugation is removed, a solution on the lower layer and solid are taken and placed at the temperature of 100-120 DEG C, the pressure is raised to 20-25 Mpa, the pressure is lowered to normal pressure after being maintained for 2-3 minutes, and drying is conducted for 20-26 hours. By means of the method, the titanium dioxide nanotubes are high in antibacterial ability and anticancer ability and capable of inhibiting growth of harmful cells durably and effectively, the effect of resisting to osteocarcinoma is particularly remarkable, and the utilization effect of the titanium dioxide nanotubes on the medical science can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of antibacterial and anticancer titanium dioxide nanotubes, more specifically, a method for preparing antibacterial and anticancer titanium dioxide nanotubes by using ruthenium complexes. Background technique [0002] The problem of bacterial infection of medical materials has resulted in the failure of a large number of transplant operations. At present, there have been some reports on improving the antibacterial ability of titanium metal, such as using antibacterial molecules such as antibiotics to improve the antibacterial effect of materials. Compared with titanium metal, titanium dioxide nanotubes can promote the formation of osteoblasts, and show great potential and advantages in the application of implants. At the same time, ruthenium complexes have attracted more and more attention because of their unique physical and chemical properties, and the properties of ruthenium are close to the iron element...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54C07F15/00A61K31/555A61P35/00A61P31/00
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司