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A preparation method of organic/inorganic hybrid double-layer nano-film self-rolling tube

A nano-membrane and inorganic technology, which is applied in the field of preparation of organic/inorganic hybrid double-layer nano-membrane self-rolling tubes, can solve problems such as deficiencies, limited applications, and non-degradable inorganic materials, and achieves mild conditions, simple size control, and easy preparation. The effect of simple process

Inactive Publication Date: 2018-08-17
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] So far, the materials for preparing micro-nanotubes are mostly inorganic materials, such as Si, SiO 2 、Al 2 o 3 、TiO 2 , due to non-degradable inorganic materials, it is not enough to be used as implant materials or drug carrier materials in the field of biomedicine
Moreover, micro-nanotubes of inorganic materials are also difficult to functionalize, which also limits their application.

Method used

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  • A preparation method of organic/inorganic hybrid double-layer nano-film self-rolling tube
  • A preparation method of organic/inorganic hybrid double-layer nano-film self-rolling tube
  • A preparation method of organic/inorganic hybrid double-layer nano-film self-rolling tube

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Experimental program
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Effect test

Embodiment 1

[0031] A. Grinding and polishing the magnesium sheet, cleaning with ethanol, cleaning with pickling solution, and then vacuum drying; the pickling solution is HNO 3 , Mg(NO 3 ) 2 and ethanol mixed solution, HNO in the mixed solution 3 The concentration is 20g / L, Mg(NO 3 ) 2 The concentration of ethanol is 150g / L, and the concentration of ethanol is 300g / L.

[0032] B. Place the magnesium sheet obtained in step A in a NaOH solution with a concentration of 3.0mol / L, and react for 3.5h at 60°C to obtain inorganic Mg(OH) on the surface of the magnesium sheet 2 film;

[0033] C, preparation concentration is the phytic acid solution of 5mg / mL, then the pH value of phytic acid solution is adjusted to 5;

[0034] D, place the magnesium flakes processed in the B step in the phytic acid solution obtained in the C step, let it stand for 10 minutes, and the phytic acid is deposited on the inorganic Mg(OH) 2 On the thin film, that is, an organic / inorganic hybrid double-layer nano-fi...

Embodiment 2

[0039] A method for preparing an organic / inorganic hybrid double-layer nano-membrane self-rolling tube, the specific steps of which are:

[0040] A. Grinding and polishing the magnesium sheet, cleaning with ethanol, cleaning with pickling solution, and then vacuum drying; the pickling solution is HNO 3 , Mg(NO 3 ) 2 and ethanol mixed solution, HNO in the mixed solution 3 The concentration is 22g / L, Mg(NO 3 ) 2 The concentration of ethanol is 140g / L, and the concentration of ethanol is 320g / L.

[0041] B. Place the magnesium sheet obtained in step A in a NaOH solution with a concentration of 2.5mol / L, and react for 4 hours at 70°C to obtain inorganic Mg(OH) on the surface of the magnesium sheet 2 film;

[0042] C. Prepare a phytic acid solution with a concentration of 6 mg / mL, and then adjust the pH value of the phytic acid solution to 6;

[0043] D, place the magnesium flakes processed in the B step in the phytic acid solution obtained in the C step, let it stand for 5 mi...

Embodiment 3

[0046] A method for preparing an organic / inorganic hybrid double-layer nano-membrane self-rolling tube, the specific steps of which are:

[0047] A. Grinding and polishing the magnesium sheet, cleaning with ethanol, cleaning with pickling solution, and then vacuum drying; the pickling solution is HNO 3 , Mg(NO 3 ) 2 and ethanol mixed solution, HNO in the mixed solution 3 The concentration is 25g / L, Mg(NO 3 ) 2 The concentration of ethanol is 160g / L, and the concentration of ethanol is 280g / L.

[0048] B. Place the magnesium sheet obtained in step A in a NaOH solution with a concentration of 3.5mol / L, and react for 3 hours at 50°C to obtain inorganic Mg(OH) on the surface of the magnesium sheet 2 film;

[0049] C. Prepare a phytic acid solution with a concentration of 4 mg / mL, and then adjust the pH value of the phytic acid solution to 5.5;

[0050] D, place the magnesium flakes processed in step B in the phytic acid solution obtained in step C, let it stand for 30min, a...

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Abstract

A method for preparing an organic / inorganic hybrid double-layer nano-membrane self-rolling tube, the steps mainly include: A, grinding and polishing the magnesium sheet, cleaning, and vacuum drying; B, placing the magnesium sheet in the step A in 2.5-3.5mol In the NaOH solution of / L, under 50-70 ℃, react 3-4h, obtain Mg(OH) on the magnesium sheet surface Thin film; Acid solution; D, the magnesium sheet of step B is placed in the phytic acid solution, let stand for 1-30min, promptly forms double-layer nano film on the magnesium sheet; E, after cleaning the magnesium sheet of D step, in 40-60 ℃ , and vacuum-dried for 6-24 hours, the organic / inorganic hybrid double-layer nano-film on the magnesium sheet is separated from the magnesium sheet and curled to obtain a self-rolling tube. The micro-nano self-rolling tubes prepared by this method are degradable and non-toxic to the human body, and are especially suitable for use in the biomedical field as implant materials or drug carrier materials; And the size is easy to adjust.

Description

technical field [0001] The invention relates to a preparation method of an organic / inorganic hybrid double-layer nano-membrane self-rolling tube. Background technique [0002] Micro-nano devices (such as micro-nano-sized tubes, wires, etc.) have been well developed in recent years in the fields of drug delivery, nanoassembly, cell biology, nanosurgery, microfluidic object transmission, microrobots, sensors, optics, chemistry, and energy. Applications. 3D micro-nano materials, especially micro-nanotubes, have been better applied because of their special three-dimensional structure and functionalization. For example, in the field of biomedicine, micro-nanotubes can be used for cell culture to control the growth of cells, can also be used to capture biomolecules, and can also be used to fix and separate enzymes and proteins; in the field of chemical pharmaceuticals, micro-nanotubes can It is used to load nanoparticles or drugs and act as a carrier for transportation; in the f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/50A61L27/54A61L31/12A61L31/14A61L31/16A61K47/02A61K47/24
Inventor 万国江张旋陈英奇赵升孟涛黄楠
Owner SOUTHWEST JIAOTONG UNIV
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