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Liquid drop micro-fluidic chip based on microlens array

A technology of microfluidic chips and microlens arrays, which is applied to laboratory containers, fluorescence/phosphorescence, laboratory utensils, etc., can solve problems such as weak fluorescence signals, and achieve improved detection throughput, enhanced intensity, and increased quantity Effect

Inactive Publication Date: 2016-02-10
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the deficiencies of the existing technology, the purpose of the present invention is to provide a droplet microfluidic chip based on a microlens array to solve the problem of weak fluorescent signals, so as to meet the detection requirements of large throughput

Method used

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  • Liquid drop micro-fluidic chip based on microlens array
  • Liquid drop micro-fluidic chip based on microlens array
  • Liquid drop micro-fluidic chip based on microlens array

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0024] Such as Figure 1-3 As shown, this case lists the droplet microfluidic chip based on the microlens array of an embodiment, including:

[0025] The chip body 1 is provided with at least one flow channel 2 on its surface;

[0026] Reflective film layer 3, which is arranged on the inner wall of flow channel 2;

[0027] The light-transmitting plate 4, whose cover is pressed above the flow channel 2; is used to seal the flow channel 2 into a closed pipeline;

[0028] The microlens 5 is arranged on the light-transmitting plate 4 and directly above the flow channel 2 . The microlens is made by using ultraviolet lithography technology to make a photoresist structure on the substrate, and then using thermal reflow technology to convert the photoresist structure into a microl...

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Abstract

The invention relates to a liquid drop micro-fluidic chip based on a microlens array. The liquid drop micro-fluidic chip comprises a chip body, a reflection membrane layer, a light transmission plate and a microlens, wherein at least one flow channel is formed in the surface of the chip body; the reflection membrane layer is arranged on an inner wall of the flow channel; the light transmission plate covers the flow channel; and the microlens is arranged on the light transmission plate and is located just above the flow channel. By using a light energy gathering property of the microlens array, a microlens array technology is combined with the liquid drop micro-fluidic chip, so that the intensity of fluorescent light received by a detector can be extremely enhanced; and by optimally designing a liquid drop flowing pipeline of a detection region and improving the quantity of parallel detection channels, the detection flux can be improved by 1-2 orders of magnitudes as compared with that of a traditional flow type technology.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to a droplet microfluidic chip based on a microlens array. Background technique [0002] Droplet microfluidic chip is a new technology for manipulating tiny amounts of liquid developed on the basis of microfluidic chip in recent years. Compared with traditional microchannel chips, the volume of microdroplets is smaller (10 -9 L-10 -12 L), flexible manipulation, uniform size, variable shape, excellent heat and mass transfer performance, and good potential for high-throughput analysis. The application of droplet microfluidic technology in the field of biochemical analysis often uses fluorescently labeled cells or molecules of interest to detect the concentration of the analyte in the sample by identifying fluorescent droplets. With the development of droplet microfluidic technology, the generation rate of droplets is continuously increasing, and accurate and high-throughput identification of ...

Claims

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Application Information

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IPC IPC(8): G01N21/64B01L3/00
Inventor 刘聪黎海文周武平蒋克明张涛
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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