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An external pharmaceutical preparation for treating meridian tendon diseases, its preparation method and application

A technology for external use of drugs and diseases, applied in medical preparations containing active ingredients, pharmaceutical formulas, bone diseases, etc., can solve the problems of drug toxicity, side effects, patient trauma, long-term treatment, surgery and other problems, and achieve good curative effect.

Active Publication Date: 2019-07-19
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tension-type headache and lumbar disc herniation are currently treated with analgesics and surgery in Western medicine. Although it can bring about a certain pain-relieving effect, it also brings toxic side effects of drugs, long treatment cycles, and surgery. Disadvantages such as trauma directly lead to a decline in the quality of life of patients; patients with hemiplegia after stroke often have clinical manifestations such as limb dysfunction, spasms, and pain without specific treatment

Method used

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  • An external pharmaceutical preparation for treating meridian tendon diseases, its preparation method and application
  • An external pharmaceutical preparation for treating meridian tendon diseases, its preparation method and application
  • An external pharmaceutical preparation for treating meridian tendon diseases, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An external pharmaceutical preparation for treating meridian diseases. Meridian diseases refer to human muscle system lesions caused by pathogenic factors, manifested as symptoms and signs of acute and chronic muscle injuries. Clinically, most diseases of muscles, joints, tendons, ligaments, and nerves can be classified as meridian diseases, such as tension-type headache, lumbar disc herniation, post-stroke hemiplegia, frozen shoulder, tendinitis, arthritis, rheumatism, etc. In this embodiment, the pharmaceutical preparation for external use for the treatment of tendon diseases includes in parts by weight:

[0025]

[0026]

[0027] Further preferably, the degree of the liquor is greater than 40 degrees, more preferably 55 degrees.

[0028] Among them, Aconitum, the correct name is Aconitum carmichaelii / Radix, the scientific name is Aconitum carmichaelii / Radix, alias goose flower, iron flower, five poisons; angiosperms, Ranunculaceae, genus Aconitum; it grows in m...

Embodiment 2

[0073] 1. Case selection:

[0074] standard constrain:

[0075] (1) There is often a history of trauma or chronic low back pain, mostly in young adults.

[0076] (2) Low back pain radiates to one or both lower extremities to the outside of the calf or dorsum of the feet, which is aggravated by activities or increased abdominal pressure, and relieved by bed rest. There may be scoliosis, limited movement of the waist, tenderness and percussion pain mostly in the waist or next to the lumbosacral spinous process, and radiate to the affected limb. The straight leg raising test was positive, and some patients caused pain on the affected side when raising the healthy leg. There are often sensory disturbances in the front or back of the calf, the dorsum of the foot or the outside of the foot, and severe cases may exceed this range. Weakened toe extensor muscles. In patients with sacral nerve root compression, the Achilles tendon reflex is weakened or disappeared; in patients with ...

Embodiment 3

[0115] 1. Case selection:

[0116] Diagnostic criteria of western medicine: Refer to the diagnostic criteria formulated by the Fourth National Cerebrovascular Disease Academic Conference in 1995.

[0117] TCM diagnostic criteria: Refer to the "Stroke Diagnosis and Curative Effect Evaluation Criteria" formulated by the Encephalopathy Emergency Cooperative Group of the State Administration of Traditional Chinese Medicine.

[0118] 2. Sample size calculation:

[0119] Referring to the sample content estimation method of the sample rate comparison of a completely random design with equal sample numbers in the two groups, set α = 0.05, β = 0.10, and according to clinical experience and literature, the recovery rate of the medicine stick group is π 1 =80%, the recovery rate of the control group was π 2 = 40%, the combined rate of the two groups = 60%, then

[0120]

[0121] If the dropout rate is estimated to be 10%, the total number of cases needs to be about 60.

[0122] 3....

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Abstract

The invention relates to the field of traditional Chinese medicine and discloses an external pharmaceutic preparation and a preparation method thereof. The external pharmaceutic preparation is prepared in the steps of soaking ten traditional Chinese medicines including monkshood, radix aconiti agrestis, prepared frankincense, prepared myrrh, asarum and the like with white spirit and extracting juice for external use, so as to treat the aponeurotic channel diseases such as tension headache, lubar intervertebral disc protrusion, hemiparalysis after apoplexy and the like. In the research of treating the tension headache, the external pharmaceutic preparation is compared with myonal by an inventor, the degree of the headache and the cranial muscle tenderness of a treatment group are obviously better than those of a contrast group, and the recurrence rate of the treatment group is 10.53% and is obviously lower than that of the contrast group by 50.00%; in the clinical research of treating the lubar intervertebral disc protrusion, the cure rate of patients is 65% and is obviously higher than that of an acupuncture group by 15%; in the clinical research of treating the hemiparalysis after the apoplexy, the improvement rates of the apoplexy diagnosis and curative effect evaluation standard rating scale, the NIHSS (National Institute of Health stroke scale) and the Barthel index are obviously higher than those of the acupuncture group, and after treatment, the proportion of (independent+lightly dependent) patients with lighter Barthel index grading degree of the treatment group is obviously higher than that of the acupuncture group.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an external pharmaceutical preparation for meridian tendon diseases, a preparation method and application thereof. Background technique [0002] Tension-type headache, lumbar disc herniation, post-stroke hemiplegia and other meridian diseases are common diseases in neurology, orthopedics and rehabilitation departments. Clinically, the main symptoms are pain and poor physical activity, which seriously affect people's daily life. Work and life, so that the patient's quality of life is reduced, and even can not take care of themselves. Tension-type headache and lumbar disc herniation are currently treated with analgesics and surgery in Western medicine. Although it can bring about a certain pain-relieving effect, it also brings toxic side effects of drugs, long treatment cycles, and surgery. Disadvantages such as trauma directly lead to a decline in the quality of life o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61P19/00A61K35/36
Inventor 俞晓飞王粤珍龚帆
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M