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Application of Procureside

A kind of technology of purple flower procured aglycone and kidney damage, which is applied in the field of medicine to achieve the effect of protecting kidney damage cells and has a wide application prospect

Active Publication Date: 2018-07-03
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report in the literature that prosauglutinin has the effect of preventing kidney damage

Method used

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  • Application of Procureside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Extraction and separation of prosteakagenin from purple flowers

[0023] Grind the rhizome of notopterygium into a coarse powder, add 6-10 times of 70% ethanol solution according to volume / mass to extract twice, each time for 1.5 hours, combine the filtrate, concentrate until it has no alcohol smell, then add water to 1 times the weight of the medicinal material; concentrate Concentrated hydrochloric acid was added to the solution to adjust the pH to 2, heated to reflux for 0.5 hours, concentrated and evaporated to dryness, and 40% ethanol solution of 1 times the weight of the medicinal material was added to completely dissolve it. After the hydrolyzate is absorbed by a D-101 macroporous resin column (diameter-to-height ratio: 1:8) twice the weight of the medicinal material, it is eluted with water for 4 column volumes, 40% ethanol for 3 column volumes, and 60% ethanol for elution. 6 column volumes. The 60% ethanol eluents were combined, the solvent was reco...

Embodiment 2

[0028] Example 2: Protective effect of procupine aglycone on cisplatin-induced HK-2 cell kidney injury model

[0029] 1. Materials and methods

[0030] 1.1 Cells Human renal tubular epithelial cells HK-2 were purchased from China Center for Type Culture Collection.

[0031] 1.2 Main reagents and instruments

[0032] Cisplatin was purchased from sigma company; Dulbecco's minimum essential medium (DMEM) / F12 culture medium, fetal bovine serum (FBS) and trypsin were purchased from Gibco, USA; MTT was purchased from Biyuntian company.

[0033] 1.3 Culture of HK-2 cells

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Abstract

The invention relates to the field of a traditional Chinese medicine technology. The invention discloses an application of nodakenetin to protection of injured renal cells, and provides a safe and effective pharmaceutical for clinically preventing renal injury. Injured renal cells can be effectively protected by using a safe dose of nodakenetin, and nodakenetin can be further developed into a renal injury protection medicament, which has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of proscurvy aglycone. Background technique [0002] The kidney is an important organ of the human body, which is used to ensure the stability of the internal environment of the body and to ensure the normal metabolism. Kidney injury is one of the common emergencies in urology. Appropriate treatment plan for kidney injury is very important to reduce the injury of patients and improve the prognosis. Therefore, in recent years, drugs for protecting kidney damage have been continuously researched and developed. [0003] Studies have found that traditional Chinese medicine has an obvious protective effect on kidney damage, and compared with western medicine, traditional Chinese medicine is milder and safer, with fewer side effects. Notopterygium, Umbelliferae, plant of the genus Notopterygium, warm in nature, dispelling exterior cold; dispelling rheumatism; sharpe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P13/12
CPCA61K31/352
Inventor 萧伟罗鑫王雪晶王红梅赵祎武黄文哲王振中周习
Owner JIANGSU KANION PHARMA CO LTD