Pharmaceutical composition for weight reduction or metabolic syndrome treatment

A technology of metabolic syndrome and composition, which is applied in the direction of drug combination, metabolic disease, pharmaceutical formula, etc., and can solve the problems such as no reports of orlistat or selistat combined with rosiglitazone.

Inactive Publication Date: 2016-02-24
QINGDAO YUNTIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports of orlistat or

Method used

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  • Pharmaceutical composition for weight reduction or metabolic syndrome treatment
  • Pharmaceutical composition for weight reduction or metabolic syndrome treatment
  • Pharmaceutical composition for weight reduction or metabolic syndrome treatment

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0013] Example 1: Preparation of compound tablets

[0014]

[0015] Preparation Process:

[0016] 1) Weigh the prescription amount of orlistat, rosiglitazone hydrochloride, starch, and microcrystalline cellulose and mix them evenly;

[0017] 2) In addition, add an appropriate amount of 5% PVP ethanol solution to the mixed powder, mix evenly, make soft material, pass through an 18-mesh sieve to make wet granules, dry at 45°C, and control the moisture of the dry granules below 1.0%;

[0018] 3) 20-mesh sieve into the granules, then mix with magnesium stearate, press tablets, and get ready.

Example Embodiment

[0019] Example 2: Preparation of compound tablets

[0020]

[0021] Preparation Process:

[0022] 1) Weigh the prescription amount of orlistat, rosiglitazone hydrochloride, mannitol and microcrystalline cellulose and mix them evenly;

[0023] 2) In addition, add an appropriate amount of 5% PVP ethanol solution to the mixed powder, mix evenly, make soft material, pass through an 18-mesh sieve to make wet granules, dry at 50°C, and control the moisture of the dry granules below 1.0%;

[0024] 3) 20-mesh sieve into the granules, then mix with magnesium stearate, press tablets, and get ready.

Example Embodiment

[0025] Example 3: Preparation of compound tablets

[0026]

[0027]

[0028] Preparation Process:

[0029] 1) Weigh the prescription amount of orlistat, rosiglitazone hydrochloride, mannitol, sorbitol, and microcrystalline cellulose and mix well;

[0030] 2) In addition, add an appropriate amount of 5% PVP ethanol solution to the mixed powder, mix evenly, make soft material, pass through an 18-mesh sieve to make wet granules, dry at 50°C, and control the moisture of the dry granules below 1.0%;

[0031] 3) A 20-mesh sieve is made into granules, then mixed with magnesium stearate palmitate, and compressed into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for weight reduction or metabolic syndrome treatment, belongs to the field of medicine and particularly relates to a pharmaceutical composition containing orlistat or cetilistat and rosiglitazone hydrochloride, wherein the composition is of solid preparations such as common tablets, dispersible tablets, sustained release tablets, capsules and granules. An accidental discovery in experiments shows that the pharmaceutical composition containing orlistat or cetilistat and rosiglitazone hydrochloride is significantly synergistically functional in lowering blood sugar and reducing weight, a preparation method is simple, operating is convenient, and the pharmaceutical composition is suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical composition for weight loss or treatment of metabolic syndrome, which belongs to the field of medicine. Background technique [0002] With the continuous improvement of living standards, changes in diet structure and transportation, people's activity level has decreased, and the obese population is increasing. There are now 7 million obese patients in my country, especially more and more adolescents are obese. There are about 30 to 40 million diabetic patients, so the incidence of patients with metabolic syndrome in our country is also very high. According to a survey conducted by the Diabetes Society of the Chinese Medical Association, the prevalence of metabolic syndrome is 14% to 16% among people over the age of 20 in urban China. Metabolic syndrome increases with age and reaches a peak in the 50-70 age group, with more women than men. Currently, there are no effective drugs on the market for the treatment...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K31/365A61K31/536A61P3/04A61P3/00
CPCA61K31/4439A61K31/365A61K31/536
Inventor 王传秀
Owner QINGDAO YUNTIAN BIOTECH
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